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WO2009081246A3 - Bicyclic diamines as nicotinic receptor agonists - Google Patents

Bicyclic diamines as nicotinic receptor agonists Download PDF

Info

Publication number
WO2009081246A3
WO2009081246A3 PCT/IB2008/003382 IB2008003382W WO2009081246A3 WO 2009081246 A3 WO2009081246 A3 WO 2009081246A3 IB 2008003382 W IB2008003382 W IB 2008003382W WO 2009081246 A3 WO2009081246 A3 WO 2009081246A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor agonists
nicotinic receptor
bicyclic diamines
diamines
bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/003382
Other languages
French (fr)
Other versions
WO2009081246A2 (en
Inventor
John Adams Lowe, Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of WO2009081246A2 publication Critical patent/WO2009081246A2/en
Publication of WO2009081246A3 publication Critical patent/WO2009081246A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds; pharmaceutically acceptable salts thereof; and stereoisomers of the compound of Formula I and pharmaceutically acceptable salts thereof; are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions and methods of treatment are also disclosed.
PCT/IB2008/003382 2007-12-19 2008-12-04 Bicyclic diamines as nicotinic receptor agonists Ceased WO2009081246A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1496307P 2007-12-19 2007-12-19
US61/014,963 2007-12-19

Publications (2)

Publication Number Publication Date
WO2009081246A2 WO2009081246A2 (en) 2009-07-02
WO2009081246A3 true WO2009081246A3 (en) 2009-09-03

Family

ID=40350166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003382 Ceased WO2009081246A2 (en) 2007-12-19 2008-12-04 Bicyclic diamines as nicotinic receptor agonists

Country Status (1)

Country Link
WO (1) WO2009081246A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2809028C (en) * 2010-08-20 2019-04-09 Research Triangle Institute Nicotinic receptor compounds
ES2886641T3 (en) 2014-08-11 2021-12-20 Angion Biomedica Corp Cytochrome P450 inhibitors and their uses
US10287282B2 (en) 2014-12-31 2019-05-14 Angion Biomedica Corp. Methods and agents for treating disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044755A1 (en) * 1999-01-29 2000-08-03 Abbott Laboratories Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands
US20020013309A1 (en) * 2000-05-25 2002-01-31 Miller Craig Harrison Pharmaceutical compositions and methods for use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044755A1 (en) * 1999-01-29 2000-08-03 Abbott Laboratories Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands
EP1359152A2 (en) * 1999-01-29 2003-11-05 Abbott Laboratories Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands
US20020013309A1 (en) * 2000-05-25 2002-01-31 Miller Craig Harrison Pharmaceutical compositions and methods for use

Also Published As

Publication number Publication date
WO2009081246A2 (en) 2009-07-02

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