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WO2009073690A1 - Système et procédé d'administration de nicotine sans tabac - Google Patents

Système et procédé d'administration de nicotine sans tabac Download PDF

Info

Publication number
WO2009073690A1
WO2009073690A1 PCT/US2008/085347 US2008085347W WO2009073690A1 WO 2009073690 A1 WO2009073690 A1 WO 2009073690A1 US 2008085347 W US2008085347 W US 2008085347W WO 2009073690 A1 WO2009073690 A1 WO 2009073690A1
Authority
WO
WIPO (PCT)
Prior art keywords
nicotine
micro
layer
central channel
filter element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/085347
Other languages
English (en)
Inventor
Sung K. Park
Douglas C. Dayton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Umagination Labs LP
Original Assignee
Umagination Labs LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Umagination Labs LP filed Critical Umagination Labs LP
Publication of WO2009073690A1 publication Critical patent/WO2009073690A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/281—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed
    • A24B15/283—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed by encapsulation of the chemical substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/20—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/60—Constructional details
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/80—Manufacture

Definitions

  • the present invention relates to a system and method for tobaccoless nicotine delivery.
  • a smoking cessation therapy comprising a nicotine replacement or phase out device that more closely resembles a cigarette and the experience of smoking a cigarette.
  • a tobaccoless nicotine delivery device permits delivery of nicotine in a manner similar to a cigarette.
  • the device may include an impermeable outer layer surrounding a micro-encapsulated nicotine layer that includes a measured amount of nicotine in a form that allows nicotine vapor to be released upon rupture of the microencapsulation.
  • a permeable membrane may be disposed adjacent to the micro- encapsulated nicotine layer that allows pressure to be applied to the micro-encapsulated nicotine layer while permitting permeation of released nicotine into a central channel for inhalation by a user.
  • a mouthpiece may be disposed at an open end of the central channel in order to provide air resistance to simulate the inhalation effect of a cigarette.
  • Fig. 1 shows a nicotine delivery device.
  • Fig. 2 shows a cross-sectional view of a nicotine delivery device.
  • Fig. 3 depicts a process for delivering nicotine from a nicotine delivery device.
  • Fig. 4 shows a nicotine delivery device using miniature nozzles to aerosolize nicotine.
  • Fig. 5 shows a nicotine delivery device using miniature nozzles to aerosolize nicotine.
  • the invention disclosed herein is a drug delivery device that delivers nicotine in a form factor similar to a cigarette but with no smoke, heat, or tobacco. This nicotine experience encourages the familiar and important social interactions that cigarettes generate including familiar tactile, oral, and visual interactions. However, the majority of the nicotine is delivered not to the lungs but to the oral and buccal cavity through which thereafter nicotine gets systemically distributed.
  • Fig. 1 shows a nicotine delivery device.
  • the nicotine delivery device 100 may be shaped and sized to resemble a cigarette or the like.
  • An impermeable outer layer 102 of the nicotine delivery device 100 which may be substantially cylindrical in shape and generally impermeable to nicotine, may include graphics or other visual content.
  • the outer layer 102 may comprise paper, fabric, plastic, metal, or any suitable material.
  • the outer layer 102 may be formed from similar materials as is found in a typical cigarette.
  • the outer layer 102 may be colored to resemble a cigarette.
  • the outer layer 102 may form a part of a vapor barrier so that nicotine contained within the device 100 can not escape to the atmosphere.
  • Fig. 2 shows a cross-sectional view of the nicotine delivery device 100 and Fig. 3 depicts a process for delivering nicotine from the nicotine delivery device 100.
  • a layer 104 of micro-encapsulated nicotine may be disposed adjacent to the impermeable outer layer 102.
  • the nicotine 108 may comprise any form of nicotine, such as the nicotine free base, i.e., (5)-3-(l-Methyl-2- pyrrolidinyl)pyridine, a compound having the formula C10H14N2 , "nicotine salt”, which refers to any mono- or bis-pharmaceutically acid addition acceptable salt or metal salt of nicotine, “pharmaceutically acceptable acid addition salt”, which refers to those salts which retain the biological effectiveness and properties of the free bases and which are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric
  • a structure 109 such as a micro-encapsulation structure may be designed to hold a precise amount of nicotine 108 in a form that will allow a nicotine vapor (see Fig. 5) to be released into a fluid stream passing around or through the layer 104.
  • the structure 109 may enclose the nicotine 108 in a nicotine-impermeable barrier or other nicotine-retaining layer that may be ruptured by finger pressure (as indicated by an arrow 110) to release the nicotine 108.
  • the structure 109 may include excipients, flavorants, nicotine-impermeable polymers and plastics, oleaginous substances (fats and oils), saccharides, proteins and other non-toxic polymeric material, co-crystallization, and so forth.
  • the structure 109 may encapsulate the nicotine 108 as nanoparticles in liposomes or using other encapsulating methods, and the like.
  • the nicotine 108 may be in any phase form, such as solid, liquid, or gaseous.
  • the nicotine 108 may be encapsulated in a gaseous soluble form, such as vaporized free base nicotine.
  • the encapsulation may also be in the form of micro-spheres.
  • the structure 109 surrounding the nicotine 108 may rupture with an applied pressure (as indicated by an arrow 110), which may include a finger pressure applied by someone holding the device 100, or flow-induced or suction pressure created by inhalation on the device 100, thus allowing the nicotine 108 to escape and enter a central channel 112 (see Fig. 2) of the nicotine delivery device where it may be delivered by inhalation to a user.
  • the impermeable outer layer 102 may inhibit the nicotine 108 from escaping the nicotine delivery device 100 should the nicotine migrate away from the central channel 112.
  • An inner layer 120 may be positioned adjacent to the layer 104 of micro-encapsulated nicotine.
  • the inner layer 120 may be substantially cylindrical and coaxial with the outer layer 102, and may provide a permeable and structural inner layer that provides a solid base against which to apply exterior force to the device 100 in order to release nicotine 108 from the layer 104 of micro-encapsulated nicotine.
  • the nicotine 108 may permeate the inner layer 120 and enter the central channel 112 for inhalation.
  • the inner layer 120 may include any gas-permeable material, such as paper, perforated plastic, polymers, and the like, as well as various combinations of these.
  • the outer layer 102 may yield upon application of a predetermined amount of pressure and the inner layer 120 may not yield (e.g., remains rigid) upon application of the predetermined amount of pressure to the outer layer, so that the structure 109 of the intermediate layer 104 ruptures and releases the nicotine 108.
  • the inner layer 120 may be permeable to ambient air.
  • a user may remove a cover that permits the exposure of the central channel 112 to air, either through an open end 105 of the device 100, or through a porous region 107 of the outer layer 102 (which may be covered by a cap when the device 100 is not in use).
  • the central channel 112 may be capped on an inhaling end by a filter element 114 or other porous element.
  • the filter element 114 may provide air resistance to simulate the inhalation effect of a cigarette but may be permeable to nicotine 108 released within the central channel 112.
  • the filter element 114 may also provide a medium for inclusion of flavorants to flavor the nicotine 108 as it passes through the filter element 114.
  • the flavorant may be menthol, tobacco, or any other flavor.
  • the filter element 114 may be a detachable element. When a user wishes to use the nicotine delivery device 100, they may attach a filter element 114 corresponding to the flavorant of their choosing. The filter element 114 may be changed during use to allow a user to try different flavorings. In an embodiment, the filter element 114 may be attached to any nicotine inhalation device, cigarette, cigar, and the like to provide flavoring.
  • the central channel 112 may be capped by a one way valve 118 or other flow restrictor to restrict the intake of nicotine upon inhalation.
  • the one way valve 118 may provide a user with a sensation of inhaling a cigarette by restricting air flow in a manner similar to a cigarette filter.
  • the one way valve 118 may take the place of the filter element 114 or work with the filter element 114 in capping the end of the nicotine delivery device.
  • a mouthpiece 122 may be placed on the end of the filter element 114 or one way valve 118.
  • the user may rupture the structure 109 surrounding the nicotine 108 in the layer 104 of microencapsulated nicotine as generally described above, and then during or after this rupturing, inhale using the mouthpiece.
  • inhalation may draw air (e.g., through the porous region 107 of the outer layer 102, or through an open end 105 of the central channel 112), and with it, nicotine 108 from the layer 104 of micro-encapsulated nicotine, into the mouth of the user from where it may be systemically distributed.
  • the nicotine delivery device 100 may include a plurality of micro-nozzles 202 for aerosolizing nicotine 108 for ingestion and/or inhalation.
  • the micro-nozzles 202 may be disposed as a layer disposed within the outer layer 102 of the device 100. As pressure is applied on the outer layer 102 (as shown in an arrow 410 in Fig. 5), the nicotine 108 may be released from the structure 109 as a nicotine vapor and enter a micro-nozzle 202 in which the nicotine becomes aerosolized.
  • the aerosolized nicotine may enter the central channel 112 directly from the micro- nozzles 202 or it may first have to permeate a permeable inner layer such as the inner layer 120 described above, which may or may not be present in addition to the micro- nozzles 202.
  • the micro-nozzles 202 may form the inner layer 120.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un dispositif d'administration de nicotine sans tabac permettant l'administration de nicotine de façon similaire à une cigarette. Le dispositif peut comprendre une couche extérieure imperméable enveloppant une couche de nicotine micro-encapsulée qui comprend une quantité mesurée de nicotine sous une forme qui permet la libération de la vapeur de nicotine au moment de la rupture de la micro-encapsulation. Une membrane perméable peut être placée en position adjacente à la couche de nicotine micro-encapsulée, ladite membrane permettant l'application d'une pression sur la couche de nicotine micro-encapsulée tout en permettant la perméation de la nicotine libérée dans un canal central et son inhalation par l'utilisateur. Un embout buccal peut être placé à une extrémité ouverte du canal central afin d'apporter une résistance à l'air et simuler l'effet d'inhalation d'une cigarette.
PCT/US2008/085347 2007-12-04 2008-12-03 Système et procédé d'administration de nicotine sans tabac Ceased WO2009073690A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99221707P 2007-12-04 2007-12-04
US60/992,217 2007-12-04

Publications (1)

Publication Number Publication Date
WO2009073690A1 true WO2009073690A1 (fr) 2009-06-11

Family

ID=40674501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/085347 Ceased WO2009073690A1 (fr) 2007-12-04 2008-12-03 Système et procédé d'administration de nicotine sans tabac

Country Status (2)

Country Link
US (1) US20090139533A1 (fr)
WO (1) WO2009073690A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT508681A1 (de) * 2009-08-19 2011-03-15 Schwarz Heribert Rauchlose zigarette
US8646461B2 (en) 2011-12-14 2014-02-11 Sentiens, Llc Device and method for simulating chemosensation of smoking
US9282772B2 (en) 2012-01-31 2016-03-15 Altria Client Services Llc Electronic vaping device
WO2014117397A1 (fr) * 2013-02-02 2014-08-07 Liu Qiuming Cigarette électronique
US20140261486A1 (en) * 2013-03-12 2014-09-18 R.J. Reynolds Tobacco Company Electronic smoking article having a vapor-enhancing apparatus and associated method
CN103380949B (zh) * 2013-03-20 2014-12-17 杭州健坤实业有限公司 茶叶保健香烟
CA3208137A1 (fr) 2013-05-06 2014-11-13 Juul Labs, Inc. Formulations de sel de nicotine pour des dispositifs de generation d'aerosol et methodes connexes
AU2014357622B2 (en) 2013-12-05 2019-10-24 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
US9854837B2 (en) * 2014-04-16 2018-01-02 Lynn Edward Hartrick Substitute cigarette for non-combustion use
US20170007594A1 (en) * 2015-07-08 2017-01-12 Niconovum Usa,Inc Therapeutic composition and configuration
US10532046B2 (en) 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US10555558B2 (en) 2017-12-29 2020-02-11 Rai Strategic Holdings, Inc. Aerosol delivery device providing flavor control

Citations (5)

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US4340072A (en) * 1979-11-16 1982-07-20 Imperial Group Limited Smokeable device
US4715389A (en) * 1986-09-15 1987-12-29 R. J. Reynolds Tobacco Company Cigarette
US5687746A (en) * 1993-02-08 1997-11-18 Advanced Therapeutic Products, Inc. Dry powder delivery system
US5799663A (en) * 1994-03-10 1998-09-01 Elan Medical Technologies Limited Nicotine oral delivery device
KR20070020830A (ko) * 2005-08-17 2007-02-22 김춘성 담배 케이스 형태의 니코틴 흡입장치

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US3635226A (en) * 1969-06-16 1972-01-18 British American Tobacco Co Tobacco-smoke filters
US4284089A (en) * 1978-10-02 1981-08-18 Ray Jon P Simulated smoking device
US4813437A (en) * 1984-01-09 1989-03-21 Ray J Philip Nicotine dispensing device and method for the manufacture thereof
US4765347A (en) * 1986-05-09 1988-08-23 R. J. Reynolds Tobacco Company Aerosol flavor delivery system
US4774971A (en) * 1986-06-03 1988-10-04 Vieten Michael J Cigarette substitute
US5167242A (en) * 1990-06-08 1992-12-01 Kabi Pharmacia Aktiebolaq Nicotine-impermeable container and method of fabricating the same
US6098632A (en) * 1992-11-25 2000-08-08 Pharmacia & Upjohn Ab Nicotine-impermeable container and method of fabricating the same
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US20030111088A1 (en) * 2001-10-29 2003-06-19 Addiction Therapies, Inc. Device and method for treating combination dependencies

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US4340072A (en) * 1979-11-16 1982-07-20 Imperial Group Limited Smokeable device
US4715389A (en) * 1986-09-15 1987-12-29 R. J. Reynolds Tobacco Company Cigarette
US5687746A (en) * 1993-02-08 1997-11-18 Advanced Therapeutic Products, Inc. Dry powder delivery system
US5799663A (en) * 1994-03-10 1998-09-01 Elan Medical Technologies Limited Nicotine oral delivery device
KR20070020830A (ko) * 2005-08-17 2007-02-22 김춘성 담배 케이스 형태의 니코틴 흡입장치

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