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WO2009073147A3 - Process for preparing bis(thiohydrazide amides) - Google Patents

Process for preparing bis(thiohydrazide amides) Download PDF

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Publication number
WO2009073147A3
WO2009073147A3 PCT/US2008/013203 US2008013203W WO2009073147A3 WO 2009073147 A3 WO2009073147 A3 WO 2009073147A3 US 2008013203 W US2008013203 W US 2008013203W WO 2009073147 A3 WO2009073147 A3 WO 2009073147A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing bis
thiohydrazide amides
amides
bis
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/013203
Other languages
French (fr)
Other versions
WO2009073147A2 (en
Inventor
Lijun Sun
Elena Kostik
Chi-Wan Lee
Kishore Ramachandran
Zhiqiang Xia
Shijie Zhang
Jun Young Choi
Jun Jiang
Shoujun Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
Original Assignee
Synta Phamaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Publication of WO2009073147A2 publication Critical patent/WO2009073147A2/en
Publication of WO2009073147A3 publication Critical patent/WO2009073147A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula (I): wherein R1, R3 and Y are defined herein.
PCT/US2008/013203 2007-11-28 2008-11-28 Process for preparing bis(thiohydrazide amides) Ceased WO2009073147A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US447607P 2007-11-28 2007-11-28
US61/004,476 2007-11-28
US474007P 2007-11-29 2007-11-29
US61/004,740 2007-11-29

Publications (2)

Publication Number Publication Date
WO2009073147A2 WO2009073147A2 (en) 2009-06-11
WO2009073147A3 true WO2009073147A3 (en) 2010-04-29

Family

ID=40459631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013203 Ceased WO2009073147A2 (en) 2007-11-28 2008-11-28 Process for preparing bis(thiohydrazide amides)

Country Status (2)

Country Link
TW (1) TW200940050A (en)
WO (1) WO2009073147A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
WO2006113695A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
WO2008024303A2 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8618170B2 (en) 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
CN115572249A (en) * 2022-09-21 2023-01-06 南京红云生物科技有限公司上海分公司 A kind of copper ion chelating agent and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927822A (en) * 1985-08-31 1990-05-22 Fisons Plc 1,3,4-thiadiazoles
WO2003006430A1 (en) * 2001-07-10 2003-01-23 Synta Pharmaceuticals Corp. Taxol enhancer compounds
EP1671957A1 (en) * 2003-10-10 2006-06-21 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927822A (en) * 1985-08-31 1990-05-22 Fisons Plc 1,3,4-thiadiazoles
WO2003006430A1 (en) * 2001-07-10 2003-01-23 Synta Pharmaceuticals Corp. Taxol enhancer compounds
EP1671957A1 (en) * 2003-10-10 2006-06-21 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BISWAS, P.K. ET AL.: "Novel ligational behaviour or thiosalicylohydrazide and its derivatives with cobalt(II), nickel(II), copper(II), and palladium(II)", J. CHEM. SOC. TRANSACTIONS, vol. 12, 1981, pages 2385 - 2394, XP009124005 *
JENSEN K A ET AL: "STUDIES OF THIOACIDS AND THEIR DERIVATIVES", ACTA CHEMICA SCANDINAVICA, MUNKSGAARD, COPENHAGEN, DK, vol. 15, no. 5, 1 January 1961 (1961-01-01), pages 1109 - 1123, XP002062580, ISSN: 0904-213X *
JENSEN, K.A. ET AL.: "Complexes de nickel avec la thiobenzhydrazide et avec des composés analogues", ACTA CHEMICA SCANDINAVICA, vol. 6, 1952, pages 189 - 194, XP002550511 *
KALINOWSKI, D.S. ET AL.: "Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: Structure-activity relationships of novel thiohydrazone analogues", J. MED. CHEM., vol. 50, 27 October 2007 (2007-10-27), pages 6212 - 6225, XP002550512 *

Also Published As

Publication number Publication date
WO2009073147A2 (en) 2009-06-11
TW200940050A (en) 2009-10-01

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