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WO2009072927A1 - Procédé de l'invention concerne la création d'un modèle médical sur la base d'informations portant sur l'image numérique d'une partie du corps - Google Patents

Procédé de l'invention concerne la création d'un modèle médical sur la base d'informations portant sur l'image numérique d'une partie du corps Download PDF

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Publication number
WO2009072927A1
WO2009072927A1 PCT/RU2008/000723 RU2008000723W WO2009072927A1 WO 2009072927 A1 WO2009072927 A1 WO 2009072927A1 RU 2008000723 W RU2008000723 W RU 2008000723W WO 2009072927 A1 WO2009072927 A1 WO 2009072927A1
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WO
WIPO (PCT)
Prior art keywords
functional element
information
teeth
additional functional
processing unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2008/000723
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English (en)
Russian (ru)
Inventor
Alexey Jurievich Remov
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2009072927A1 publication Critical patent/WO2009072927A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C9/00—Impression cups, i.e. impression trays; Impression methods
    • A61C9/004—Means or methods for taking digitized impressions
    • A61C9/0046—Data acquisition means or methods
    • A61C9/0053—Optical means or methods, e.g. scanning the teeth by a laser or light beam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A61C13/0004—Computer-assisted sizing or machining of dental prostheses
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture

Definitions

  • the claimed invention relates to medicine, in particular to dentistry, maxillofacial surgery. It relates to a method for creating a medical template based on information about a digital image of a body part and a future orthopedic design or without information about a future orthopedic design.
  • medical template means a temporarily placed positioning part on a part of the body (bone, oral mucosa, teeth, orthopedic structure, etc.) for performing a surgical operation, for example, dental implantation, in particular, for precise drilling of holes through it in the bone for the subsequent installation of implants (that is, in other words, this part, for example, indicates the direction, place and depth of drilling of the hole in the bone).
  • a surgical operation for example, dental implantation, in particular, for precise drilling of holes through it in the bone for the subsequent installation of implants (that is, in other words, this part, for example, indicates the direction, place and depth of drilling of the hole in the bone).
  • this part for example, indicates the direction, place and depth of drilling of the hole in the bone.
  • body part in the text of this application refers to the part of the jaw, the entire jaw, teeth, bones, and other tissues of the body.
  • information is first obtained on a digital image of a body part, for example, a jaw, in particular, made using a computed tomography scanner or any other digital image processing device, for example, a magnetic resonance imager.
  • the patient comes to the X-ray room, sits in a chair or lies on the table. Then the table or chair enters the computer tomograph. The corresponding parts of the body are X-rayed and the information obtained with the help of appropriate sensors is processed in a computer into information about the digital image of the part of the body.
  • the next operation of the known method is that the received information about the digital image of the body part is sent to the data processing unit.
  • digital information about at least one functional element in the created medical template can be sent to the data processing unit, and digital information about this functional element can be sent either from external sources or received inside the data processing unit.
  • a functional element is understood, for example, as a through hole in a medical template, through which, at the time of a surgical operation, drilling into bones is performed with a useful function: indicating the location and direction of drilling.
  • the functional element may have other embodiments, for example, it may be a groove on the side of the medical template, and so on.
  • the subsequent operation of the known method consists in converting the received digital information using a data processing unit into a virtual model with the ability to add at least one functional element with a useful function as a digital information function (the position of the future implant in the jaw bone, the position of the drilling axis, etc.), and, as noted above, this digital information about this functional element can be sent both from external sources and can be received inside the sampler data processing.
  • the processed data is sent to a prototyping device, which creates a medical template, at least part of which shows data on at least some parts of this part of the body.
  • the disadvantage of this method is that it cannot be applicable for patients with fixed prostheses, for example, bridges, crowns or stump inserts in teeth made of metal or elements of a dense structure. This is due to the fact that a metal or a dense structure element during scanning produces artifacts in a digital image (in other words, it creates such strong interference in the image that it is sometimes impossible to distinguish tissue boundaries). For this reason, under these circumstances, the method is not applicable. For its use, it is necessary to remove all fixed structures installed in the teeth and / or teeth, that is, destroy the structures that perform their function (remove crowns, bridges, stump inserts, fill the teeth, destroy everything). This circumstance greatly narrows the scope of the method.
  • Another disadvantage of this method is that when it is used, additional information about other teeth, orthopedic structures (crowns, bridges) that already exist in the oral cavity and do not fall into the scan area is not used. Let us explain this in more detail using an example.
  • a functional element with a useful function is mentioned, for example, an opening in a medical template through which at the time of surgery operations produce drilling in the bone.
  • a functional element with a useful function is added to the data processing unit as a function of digital information and possibly a function of additional external information.
  • the functional element in the prototype is formed either by entering information about it using some external means or it is created due to information about the digital image of the body part.
  • the known method does not provide any manipulations in the oral cavity to obtain information:
  • an additional functional element is introduced into the patient’s oral cavity with the useful function of obtaining additional digital information about the oral cavity, which also enters the data processing unit, • the additional functional element being placed at least in an area about which it is not possible to obtain sufficient digital information .
  • the claimed method provides the ability to perform operations without incision and separation of the mucosa from the bone (medical template based on teeth, mucous membranes and orthopedic structures). The drilling accuracy is increased when installing the implant in direction and depth and the ability to accurately transfer the planned situation in the data processing unit to the oral cavity.
  • the additional functional element may be an element of an impression material having X-ray contrast properties, or a temporary prosthesis of X-ray contrast material, or a permanent removable prosthesis of material having the property of X-ray contrast.
  • the technical result of the claimed invention is without destruction of previously installed and performing their function orthopedic structures (but interfering with a digital image of a body part), for example, metal, to obtain more accurate information about a digital image of a body part with metal objects present in the oral cavity (jaw, mucous membrane, teeth, orthopedic structures) with the ability to accurately distinguish the boundaries of these tissues and create medical template with useful functional element.
  • the interference is “not absorbed” in the digital image, but, according to the invention, in the data processing unit, knowing the density thresholds of the impression material with radiopaque properties, we can distinguish the surface of this material and, accordingly, using standard techniques to highlight the boundaries fabrics that were printed in this material This operation is not disclosed in the application, since it is standard in the processing of three-dimensional images: determining a threshold (segmentation based on gray gradations), three-dimensional reduction, expansion, expansion of areas, boolean operations, such as combining and taking the difference, etc.
  • X-ray contrast of a material we generally mean the possibility of a material during an X-ray examination to clearly see its borders or the borders of the tissues to which it adjoins, for example, to examine the gastrointestinal tract, the patient is given barium sulfate before X-ray examination to see if there are any changes in the gastrointestinal mucosa tract.
  • a radiopaque material or impression material having radiopaque properties is a standard impression material used for making an impression in orthopedic dentistry, which in its chemical structure has such a degree of radiopacity, which helps to distinguish it clearly in a digital image, for example, impression materials of the following brands: manufacturer Kegg company (material: Kegr Traau), manufacturer ZM company (material: ZM-Expess Reptut), manufacturer Zhermask company (material: Zhegmask Zetarlus), etc. If the impression material has the specified property of radiopaque, then it can be used to implement the claimed method.
  • an additional functional element is an element from the “usual” impression material (both having radiopaque properties and not having radiopaque properties), which makes it possible to obtain an accurate representation of the relief of the oral cavity as a result of the following technique: an impression of the oral cavity is taken, a model is cast on it and the resulting model is used for additional scanning with the ability to transmit digital information to the data processing unit.
  • impression material that does not have radiopaque properties. It should be noted that this technique can also be used when using cast material with radiopaque properties.
  • impression material with radiopaque properties As an additional functional element, an important special case is possible when additional digital information about antagonist teeth in occlusion is obtained (normal closed position of the oral cavity). In this case, an impression of teeth is obtained in the impression material in the position of the bite, located at least in front of the area in which the implants will be installed. This makes it possible to obtain additional digital information about these teeth in the state of occlusion.
  • An area about which it is not possible to obtain sufficient digital information and, at least, on which an additional functional element is laid, can represent, in particular, the mucosa, teeth, orthopedic structures, various combinations of surfaces of orthopedic structures and / or teeth and / or mucous membranes.
  • an additional functional element is added as a function of information about the digital image in the form in which all medical data are obvious.
  • information from an additional functional element is processed in a data block using a computer system focused on volumetric image elements, for example, voxels.
  • a method of creating a medical template based on information about a digital image of a body part it can be used an additional operation, which consists in the introduction of solid bushings into the functional element of the medical template for precise drilling in direction and depth.
  • the use of solid bushings allows the milling cutter to achieve a smooth translational motion and better alignment.
  • Carrying out the claimed method using bushings is one of the preferred private methods of carrying out the claimed method, increasing the accuracy of drilling holes in the bones for the installation of implants.
  • the introduction of the bushings can be carried out in various ways, for example, by hammering, screwing, gluing, fusing, etc.
  • the bushings themselves can be made of various materials, for example, metal, ceramics.
  • the installation of the bushings in the medical template can be carried out in various ways.
  • the medical template is made of plastic material, and the sleeves are made of solid material, and for installation, each sleeve is inserted by pressing into a functional element, which is, for example, a through hole, in particular a round or square shape in plan.
  • plastic polymer
  • the functional element may have other embodiments, for example, it may be a groove on the side of the medical template.
  • the medical template can be made not only of a plastic material, but also of a solid material, for example, metal or ceramic.
  • FIG. 1 depicts a general flowchart of a method for creating a medical template in accordance with the invention
  • FIG. 2 schematically shows the jaw with gums and teeth at the beginning of treatment, sagital section
  • FIG. 3 the same, in the process of setting the impression mass;
  • FIG. 4 the same after closing the teeth;
  • FIG. 5 schematically at the time of scanning the jaw with gum and teeth and with the impression mass in which antagonist teeth were imprinted are depicted
  • FIG. 6 depicts a separate medical template with functional elements (through holes) made according to the claimed method
  • FIG. 7 is the same, section A-A of FIG. 6;
  • FIG. 8 is the same, section A-A of FIG. 6 with a sleeve installed in a functional element representing a through hole;
  • FIG. 9 schematically shows the jaw with gum and teeth at the time of installation of the medical template at the time of surgery.
  • the method is illustrated by an example of a device 1 implementing the method of FIG. 1, in particular, by way of example, the treatment of a patient indicated by 2.
  • the device 1 may have several options. One of them will be described in full below, and then some other possible options will be disclosed.
  • the specified device 1 includes a scanner 3 that scans the patient.
  • a scanner a computer tomograph can be used.
  • the scanner 3 we get the digitized image 4, containing digitized medical information.
  • the digitized image 4 is processed in the data processing unit 5.
  • a three-dimensional visual image 6 and / or tomographic image 7 can be used, which are formed in the usual standard way from digitized images 4 (not disclosed, since they are well known, see, for example, the closest analogue).
  • the visual three-dimensional image 6 and the tomographic image 7 are shown in Figure 1.
  • the claimed device 1 provides, along with sending to the data processing unit 5 information about the digital image of the body part, it is also possible to send digital information about at least one functional element, for example, about a hole in a virtual model, and digital information about this functional element can be sent both from external sources, to Reamer, position coordinates directed to the other device, and to receive in the data processing unit 5 (these techniques are standard and therefore not shown).
  • the obtained information is converted and a virtual model is created with the possibility of adding at least one functional element to it with a useful function as a function of digital information.
  • data on the obtained virtual model is sent to the prototyping device 8, which creates a medical template 9, at least part of which clearly shows data on at least some parts of this body part.
  • the medical template is installed in the oral cavity of the patient 2 for its subsequent use for drilling through it holes in the bones installed in a well-known manner, which is not disclosed in the materials of this application, since it is not related to the object of the invention and is well known.
  • a distinctive common essential feature of the claimed method is that before receiving information about the digital image of the body part, an additional functional element 10 is introduced into the oral cavity of the patient 2 (see Fig. 1), with the useful function of obtaining additional digital information about the oral cavity, the additional functional element 10 is stacked at least in an area with which due to its features it is not possible to obtain sufficient digital information about it. Consider this issue in detail.
  • the lower jaw 11 and the upper jaw 12 with the gum 13 and teeth 14 have areas from which, due to their features, it is not possible to obtain sufficient digital information.
  • such areas are metal crowns 15 on some teeth, as well as part 16 without gum teeth 13.
  • these areas do not make it possible to distinguish them without errors in the digital image of the body part (in this case, the jaw refers to the body part) , teeth of the jaw and other tissues), as a result of which the prototype cannot be used to create a model of a medical template. For this reason, crowns must be removed before applying the prototype method.
  • the inventive method proposes to introduce an additional functional element 10, which is often an element of impression material with radiopaque properties, before scanning into the oral cavity of patient 1.
  • this element is made of impression material with radiopaque properties, specifically represents an radiopaque impression mass 17.
  • the radiopaque impression mass 17 would be stacked at least in the area from which, due to its features, it is not possible to obtain sufficient digital information about it.
  • such an area is the area 18 of the surface of the metal crown 15 on the tooth of the lower jaw, as well as part 16 without gum teeth 13.
  • the radiopaque impression mass 17 has the ability to take after hardening the imprint of the shape of the object on which it was applied, and most importantly, after processing the data in the data processing unit 5, it becomes possible to obtain a clear virtual model of the object from which the impression was taken. This operation is not disclosed, since it is standard in processing three-dimensional images: determining a threshold (segmentation based on grayscale), three-dimensional reduction, expansion, expansion of areas, Boolean operations, such as combining and taking the difference, designing, etc.).
  • the patient After laying the impression mass 17, the patient closes the teeth (Fig. 4) and after hardening the teeth open. Imprints 19 from the antagonist teeth 20 of the upper jaw 12 remain in the impression mass (Fig. 5).
  • the patient is sent for scanning by the scanner 3. When scanning the patient is placed between the source 21 of the x-ray radiation and the sensor 22.
  • impression mass makes it possible not only to obtain a clear image, but also to more accurately plan the operation of dental implantation, taking into account the position of the upper teeth. This makes it possible, without scanning teeth 20, to obtain the necessary digital information and in block 5 data processing to create a virtual model of these teeth in a state of bite relationships.
  • FIG. 5 schematically depicts jaws with a gum and teeth and a cast mass in which antagonist teeth are imprinted. After scanning, digital information enters the data processing unit 5 (Fig. 1).
  • digital information about at least one functional element with a useful function (the position of the future implant in the jaw bone, the position of the drilling axis, etc.) is attached to it, and this digital information about this functional element can be sent both from external sources, and get inside the data processing unit.
  • digital information is sent to a prototyping device 8, which makes a medical template 9 with a functional element (for example, a hole).
  • a medical template 9 with a functional element for example, a hole.
  • FIG. 6 depicts separately a medical template 9 with functional elements in the form of holes 23, made according to the claimed method.
  • FIG. 7 is the same, section AA of FIG. 6.
  • solid bushings 24 are inserted into each functional element in the form of a hole 23 in the medical template 9, which perform positioning functions when drilling the bone (provide the direction of drilling in position and depth) (see Fig. 8, which shows the AA section of Fig. 6 with the installed a sleeve in the functional element representing the hole 23).
  • the introduction of the sleeves 24 can be carried out by driving, screwing (if there is a thread on the outer surface of the sleeve 24 and the inner surface of the hole 23), gluing, fusion, etc.
  • the sleeve itself, in order to be solid, can be made of metal (for example, titanium, steel, etc.), ceramics, etc.
  • the medical template may be made of plastic solid material (in particular, plastic, polymer, etc.). Since the medical template is made of plastic material and the sleeve is solid, the sleeve is installed by pressing it into a functional element, which is a through hole, for example, round, square, etc. shapes in plan.
  • the functional element may have other embodiments. In particular, it may be a groove on the side of the medical template 9.
  • the medical template can be made of solid material, for example, plastic, metal, ceramics, etc., in this case there is no need to install the sleeve in the functional element.
  • the medical template is sent either to the laboratory for the manufacture of the orthopedic structure or to the operating room for the operation, for example, dental implantation (implant implantation into the bone tissue of the jaw).
  • dental implantation implant implantation into the bone tissue of the jaw.
  • FIG. 9 schematically shows the jaw with gum and teeth at the time of installation of the medical template at the time of surgery.
  • a temporary prosthesis of radiopaque material or a permanent removable prosthesis can be used.
  • An additional functional element is placed in the oral cavity on the mucosa, teeth, orthopedic structures. Moreover, in one oral cavity, various combinations of areas of orthopedic structures and / or teeth and / or mucous membranes are possible, on which an additional functional element is laid. Example, mucous membranes and teeth; teeth and orthopedic construction; just teeth; mucous membranes, teeth and orthopedic construction; etc. This is one of the variants of the claimed method. Its feature is that the patient is scanned with an additional functional element.
  • a variant is possible whose key operation is depicted in FIG. 1 with a dashed arrow, indicated at 25, in which a mold is taken from the jaw in the oral cavity according to the standard method: the impression mass (not necessarily radiopaque) is placed in the impression spoon, inserted into the oral cavity, the spoon with the impression mass is squeezed onto the jaw with or without teeth , after hardening the impression mass, the spoon with it is removed from the oral cavity, then the model is cast according to this mold, the spoon with the impression mass is removed from the model. As a result of these actions, an exact copy of the state of the oral cavity is obtained. The model is sent to the scanner 3.
  • the impression mass not necessarily radiopaque
  • the peculiarity of this option is that the patient is scanned separately, for example, in a computed tomography scanner (to obtain a digital image of the desired area), and the above model is scanned separately, for example, in an external form scanning 3D scanner (to obtain a digital image of the model, which displays the surface of the studied area without distortion from the influence of interference caused by metal objects).
  • This makes it possible to combine this data in the data processing unit 5 and to exclude artifacts on the virtual model caused by metal objects obtained by scanning the patient in a computer tomograph.
  • an additional functional element is introduced into the patient’s oral cavity with the useful function of obtaining additional digital information about the oral cavity, the additional functional element being placed at least in the area which due to its features it is not possible to obtain sufficient digital information about it), and the difference is that the patient is scanned without an additional functional element, the relief of which is scanned separate.
  • the additional functional element is an element of impression material, at least not having radiopaque properties, and, when using it, an oral impression is taken, a model is cast on it and the resulting model is used for additional scanning with the ability to transmit digital information to the data processing unit (paragraph 5 of the claims).
  • an element of impression material, at least not having radiopaque properties means that it can be used independently as an element of impression material that does not have radiopaque properties, or independently an element of impression material with radiopaque properties.
  • a modification of the claimed method is possible, according to which when using impression material with radiopaque properties as an additional functional element, an impression of teeth is obtained in the impression material in the position of the bite, located at least opposite to the area in which the implants will be installed.
  • the peculiarity of this option is that when using impression material with radiopaque properties as an additional functional element, a patient with an open mouth is scanned, for example, in a computer tomograph (to obtain a digital image of the desired area). In this case, one jaw can be scanned, and the necessary digital information about the surface of the teeth of the unscanned jaw can be obtained, and in the position of normal closing of the teeth.
  • the invention is illustrated by a clinical example.
  • Diagnosis partial adentia on the lower jaw. A removable denture is fixed on the remaining 33.43 teeth.
  • the patient due to his active social activities, cannot remain without a denture in the oral cavity.
  • the operation lasted 15 minutes, and the previous 1 hour. She was successful. There was no edema and severe pain after the operation, because the implants were inserted without separating the mucous membrane and periosteum from the bone.
  • the invention is intended for use in medical institutions.
  • the use of the claimed invention can significantly improve the results of surgical treatment.
  • the use of the claimed invention can significantly expand the possibilities of providing high-tech care to patients who also have fixed prostheses, for example, bridges, crowns or stump inserts in teeth made of metal or elements of a dense structure, without destroying previously installed and performing their function orthopedic structures that create interference, to obtain accurate information about the digital image of a part of the body (jaw, mucous membrane, teeth, orthopedic structures) with the ability internally to allocate the border of these tissues and obtain a virtual model of a useful functional element, as well as create a medical template, just adjacent to the corresponding part of the body because of its topography (jaw, mucosa, teeth, prosthetics) with useful functional element.
  • fixed prostheses for example, bridges, crowns or stump inserts in teeth made of metal or elements of a dense structure
  • a traumatic TM operation is reduced, since in the presence of interference caused by crowns, bridges, stumps, it is possible to perform operations without cutting and separating the mucous membrane from the bone (medical template based on teeth, mucous membranes and orthopedic structures).
  • the invention improves the accuracy of drilling when installing the implant in direction and depth and the ability to accurately transmit the planned situation in the data processing unit to the oral cavity.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Prostheses (AREA)

Abstract

Le procédé de l'invention concerne la création d'un modèle médical sur la base d'informations portant sur l'image numérique d'une partie du corps; le procédé comprend la réception des informations sur l'image numérique de la partie du corps, la transmission des informations sur l'image numérique de la partie du corps à une unité de traitement de données de sorte à permettre également de transmettre à l'unité de traitement de données numériques des informations sur au moins un élément fonctionnel, les informations pouvant être envoyées à partir de sources externes ou obtenues de l'unité de traitement de données. L'invention concerne égalementun procédé de conversion, à l'aide de l'unité de traitement de données, des informations reçues en un modèle virtuel de façon à permettre d'y ajouter au moins un élément fonctionnel avec une fonction utile en tant que fonction des informations numériques. On transmet les données traitées à une unité de prototypage à des fins de production d'un modèle médical dont au moins une partie présente des données sur au moins plusieurs régions de cette partie du corps; à cet effet, un élément fonctionnel avec une fonction utile permettant de recevoir des informations numériques sur la cavité buccale est introduit dans la cavité buccale du patient, ledit élément fonctionnel étant posé sur au moins une zone dont il n'est pas impossible d'obtenir suffisamment d'informations numériques.
PCT/RU2008/000723 2007-12-07 2008-11-27 Procédé de l'invention concerne la création d'un modèle médical sur la base d'informations portant sur l'image numérique d'une partie du corps Ceased WO2009072927A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2007145324 2007-12-07
RU2007145324/14A RU2369354C2 (ru) 2007-12-07 2007-12-07 Способ создания медицинского шаблона на основе информации о цифровом изображении части тела

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WO2009072927A1 true WO2009072927A1 (fr) 2009-06-11

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US20120261848A1 (en) * 2009-12-23 2012-10-18 Haraszati Gyoergy Method to create removable dental prosthesis, and the dental prosthesis making thereof
RU2470609C2 (ru) * 2011-03-09 2012-12-27 Дмитрий Евгеньевич Суетенков Способ установки ортодонтического микроимплантата и шаблон для его осуществления
RU2492816C1 (ru) * 2012-03-30 2013-09-20 Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития Способ оперативного лечения больных опухолью почки
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WO2016043578A1 (fr) * 2014-09-19 2016-03-24 Stichting Vu-Vumc Kit pour l'implantation d'un implant dentaire
RU2576873C1 (ru) * 2014-12-09 2016-03-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ внутриротовой рентгенографии (варианты)
RU2698047C1 (ru) * 2019-01-17 2019-08-21 Общество с ограниченной ответственностью "Ортосмайл" Способ установки ортодонтического аппарата, шаблон и ортодонтический аппарат
RU2760296C1 (ru) * 2021-06-23 2021-11-23 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Направляющий шаблон для мягкотканной трансплантации

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