WO2009072562A1 - 有機酸の製造方法 - Google Patents
有機酸の製造方法 Download PDFInfo
- Publication number
- WO2009072562A1 WO2009072562A1 PCT/JP2008/072055 JP2008072055W WO2009072562A1 WO 2009072562 A1 WO2009072562 A1 WO 2009072562A1 JP 2008072055 W JP2008072055 W JP 2008072055W WO 2009072562 A1 WO2009072562 A1 WO 2009072562A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- organic acid
- bacterium
- belongs
- producing
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01031—Phosphoenolpyruvate carboxylase (4.1.1.31)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ホスホエノールピルビン酸カルボキシキナーゼ活性が増強するように改変された有機酸生産能を有する腸内細菌科に属する細菌であって、エンテロバクター属、パントエア属、エルビニア属、クレブシエラ属、及びラウルテラ属から選択される細菌、又は該細菌の処理物を、炭酸イオン、重炭酸イオン、または二酸化炭素ガスを含有する反応液中で有機原料に作用させることによって、有機酸を生成させ、該有機酸を採取することにより、有機酸を製造する。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08857657.4A EP2241630B1 (en) | 2007-12-06 | 2008-12-04 | A method for producing an organic acid |
| JP2009544711A JP5644108B2 (ja) | 2007-12-06 | 2008-12-04 | 有機酸の製造方法 |
| US12/793,107 US8247201B2 (en) | 2007-12-06 | 2010-06-03 | Method for producing an organic acid |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007-315764 | 2007-12-06 | ||
| JP2007315764 | 2007-12-06 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/793,107 Continuation US8247201B2 (en) | 2007-12-06 | 2010-06-03 | Method for producing an organic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2009072562A1 true WO2009072562A1 (ja) | 2009-06-11 |
Family
ID=40717739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2008/072055 Ceased WO2009072562A1 (ja) | 2007-12-06 | 2008-12-04 | 有機酸の製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8247201B2 (ja) |
| EP (1) | EP2241630B1 (ja) |
| JP (1) | JP5644108B2 (ja) |
| WO (1) | WO2009072562A1 (ja) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019175A3 (en) * | 2010-08-06 | 2012-04-19 | Mascoma Corporation | Production of malonyl-coa drived products via anaerobic pathways |
| US8247201B2 (en) | 2007-12-06 | 2012-08-21 | Ajinomoto Co., Inc. | Method for producing an organic acid |
| JP2012522515A (ja) * | 2009-04-02 | 2012-09-27 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | コハク酸生産経路の工学処理 |
| JP2014150747A (ja) * | 2013-02-06 | 2014-08-25 | Sekisui Chem Co Ltd | 変異微生物、並びに、コハク酸の生産方法 |
| WO2015005406A1 (ja) | 2013-07-09 | 2015-01-15 | 味の素株式会社 | 有用物質の製造方法 |
| WO2016104814A2 (en) | 2014-12-26 | 2016-06-30 | Ajinomoto Co., Inc. | Method for producing dicarboxylic acid |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010137130A1 (ja) | 2009-05-27 | 2010-12-02 | 味の素株式会社 | 有機酸の製造方法 |
| WO2011063055A2 (en) | 2009-11-18 | 2011-05-26 | Myriant Technologies Llc | Engineering microbes for efficient production of chemicals |
| EP2821479A4 (en) | 2012-02-29 | 2015-09-02 | Ajinomoto Kk | ESCHERICHIA COLI WITH THE PRODUCTIVITY OF 3-AMINO-4-HYDROXYBENZOIC ACID |
| CN104379742A (zh) | 2012-05-29 | 2015-02-25 | 味之素株式会社 | 生产3-乙酰氨基-4-羟基苯甲酸的方法 |
| EP3856918A1 (en) | 2018-09-28 | 2021-08-04 | Ajinomoto Co., Inc. | Method for producing l-methionine using a bacterium |
| BR112021014194A2 (pt) | 2019-02-22 | 2021-12-28 | Ajinomoto Kk | Método para a produção de um l-aminoácido |
| BR112021017870A2 (pt) | 2019-04-05 | 2021-12-07 | Ajinomoto Kk | Método para produzir um l-aminoácido |
| WO2021060438A1 (en) | 2019-09-25 | 2021-04-01 | Ajinomoto Co., Inc. | Method for producing l-amino acids by bacterial fermentation |
Citations (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02109985A (ja) | 1988-02-22 | 1990-04-23 | Eurolysine | 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌 |
| JPH02207791A (ja) | 1989-02-07 | 1990-08-17 | Ajinomoto Co Inc | 微生物の形質転換法 |
| JPH04189822A (ja) | 1990-11-26 | 1992-07-08 | Showa Highpolymer Co Ltd | 脂肪族ポリエステルの製造方法 |
| US5142834A (en) | 1990-07-12 | 1992-09-01 | Donnelly Corporation | Vehicle trim assembly and fastener therefor |
| JPH057491A (ja) | 1990-10-15 | 1993-01-19 | Ajinomoto Co Inc | 温度感受性プラスミド |
| JPH0568576A (ja) | 1991-09-11 | 1993-03-23 | Mitsubishi Petrochem Co Ltd | コハク酸の製造法 |
| JPH07107976A (ja) | 1993-10-15 | 1995-04-25 | Mitsubishi Chem Corp | 挿入配列 |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| WO1997016528A1 (en) | 1995-11-02 | 1997-05-09 | The University Of Chicago | A mutant e. coli strain with increased succinic acid production |
| WO1998004715A1 (en) | 1996-07-30 | 1998-02-05 | Archer-Daniels-Midland Company | Novel strains of escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production |
| JPH11113588A (ja) | 1997-10-09 | 1999-04-27 | Mitsubishi Chemical Corp | 含酸素化合物の製造方法 |
| JPH11196887A (ja) | 1998-01-16 | 1999-07-27 | Mitsubishi Chemical Corp | ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| JPH11196888A (ja) | 1998-01-16 | 1999-07-27 | Mitsubishi Chemical Corp | ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| EP0952221A2 (en) | 1998-03-18 | 1999-10-27 | Ajinomoto Co., Ltd. | L-Glutamic acid-producing bacterium and method for producing L-glutamic acid |
| EP0955368A2 (en) | 1998-03-18 | 1999-11-10 | Ajinomoto Co., Ltd. | L-glutamic acid-producing bacterium and method for producing l-glutamic acid |
| WO2000018935A1 (en) | 1998-09-25 | 2000-04-06 | Ajinomoto Co.,Inc. | Process for constructing amino acid-producing bacterium and process for producing amino acid by fermentation method with the use of the thus constructed amino acid-producing bacterium |
| US6303383B1 (en) | 1999-03-16 | 2001-10-16 | Ajinomoto Co., Inc. | Temperature sensitive plasmid for coryneform bacteria |
| WO2005010175A1 (en) | 2003-07-29 | 2005-02-03 | Ajinomoto Co., Inc. | Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity |
| JP2005058827A (ja) | 2003-08-15 | 2005-03-10 | Asano Koji Kk | 有機性汚水の処理方法 |
| WO2005021770A1 (ja) | 2003-08-28 | 2005-03-10 | Mitsubishi Chemical Corporation | コハク酸の製造方法 |
| WO2005052135A1 (en) | 2003-11-27 | 2005-06-09 | Korea Advanced Institute Of Science And Technology | Novel rumen bacteria variants and process for preparing succinic acid employing the same |
| JP2005168401A (ja) | 2003-12-11 | 2005-06-30 | Mitsubishi Chemicals Corp | 非アミノ有機酸の製造方法 |
| US20050170482A1 (en) | 2003-11-14 | 2005-08-04 | Rice University | Aerobic succinate production in bacteria |
| WO2005113744A1 (ja) | 2004-05-20 | 2005-12-01 | Ajinomoto Co., Inc. | コハク酸生産菌及びコハク酸の製造方法 |
| WO2005113745A1 (ja) | 2004-05-20 | 2005-12-01 | Ajinomoto Co., Inc. | コハク酸生産菌及びコハク酸の製造方法 |
| WO2005116227A1 (en) | 2004-05-03 | 2005-12-08 | Ut-Battelle, Llc | A method to produce succinic acid from raw hydrolysates |
| WO2006031424A2 (en) | 2004-08-27 | 2006-03-23 | Rice University | Mutant e. coli strain with increased succinic acid production |
| JP2006180782A (ja) | 2004-12-27 | 2006-07-13 | Hiroshima Univ | バイオディーゼル廃液からの水素およびエタノールの製造方法、並びに当該方法を行なうためのキット |
| WO2006107127A1 (en) | 2005-04-08 | 2006-10-12 | Korea Advanced Institute Of Science And Technology | Method for improving a strain based on in-silico analysis |
| JP2006320208A (ja) | 2005-05-17 | 2006-11-30 | Mitsubishi Chemicals Corp | コハク酸の製造方法 |
| WO2007007933A1 (en) | 2005-07-11 | 2007-01-18 | Korea Advanced Institute Of Science And Technology | Method of in-silico improvement of organisms using the flux sum of metabolites |
| WO2007037460A1 (en) | 2005-09-27 | 2007-04-05 | Ajinomoto Co., Inc. | An l-amino acid-producing bacterium and a method for producing l-amino acids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2036188T3 (es) * | 1986-06-11 | 1993-05-16 | Michigan Biotechnology Institute | Un procedimiento para la produccion de acido succinico por fermentacion anaerobia. |
| CN101023178A (zh) * | 2004-09-17 | 2007-08-22 | 莱斯大学 | 高琥珀酸产出细菌 |
| JP4595506B2 (ja) * | 2004-11-25 | 2010-12-08 | 味の素株式会社 | L−アミノ酸生産菌及びl−アミノ酸の製造方法 |
| JP2010017081A (ja) * | 2006-10-10 | 2010-01-28 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
| JP5493854B2 (ja) * | 2007-04-10 | 2014-05-14 | 味の素株式会社 | 有機酸の製造方法 |
| WO2008133131A1 (ja) * | 2007-04-16 | 2008-11-06 | Ajinomoto Co., Inc. | 有機酸の製造方法 |
| BRPI0810011B1 (pt) * | 2007-04-17 | 2021-11-30 | Ajinomoto Co., Inc | Método para produzir uma substância ácida tendo um grupo carboxila |
| EP2241630B1 (en) | 2007-12-06 | 2016-06-01 | Ajinomoto Co., Inc. | A method for producing an organic acid |
-
2008
- 2008-12-04 EP EP08857657.4A patent/EP2241630B1/en not_active Not-in-force
- 2008-12-04 WO PCT/JP2008/072055 patent/WO2009072562A1/ja not_active Ceased
- 2008-12-04 JP JP2009544711A patent/JP5644108B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-03 US US12/793,107 patent/US8247201B2/en not_active Expired - Fee Related
Patent Citations (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02109985A (ja) | 1988-02-22 | 1990-04-23 | Eurolysine | 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌 |
| JPH02207791A (ja) | 1989-02-07 | 1990-08-17 | Ajinomoto Co Inc | 微生物の形質転換法 |
| US5142834A (en) | 1990-07-12 | 1992-09-01 | Donnelly Corporation | Vehicle trim assembly and fastener therefor |
| JPH057491A (ja) | 1990-10-15 | 1993-01-19 | Ajinomoto Co Inc | 温度感受性プラスミド |
| JPH04189822A (ja) | 1990-11-26 | 1992-07-08 | Showa Highpolymer Co Ltd | 脂肪族ポリエステルの製造方法 |
| JPH0568576A (ja) | 1991-09-11 | 1993-03-23 | Mitsubishi Petrochem Co Ltd | コハク酸の製造法 |
| JPH07107976A (ja) | 1993-10-15 | 1995-04-25 | Mitsubishi Chem Corp | 挿入配列 |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| WO1997016528A1 (en) | 1995-11-02 | 1997-05-09 | The University Of Chicago | A mutant e. coli strain with increased succinic acid production |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| WO1998004715A1 (en) | 1996-07-30 | 1998-02-05 | Archer-Daniels-Midland Company | Novel strains of escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production |
| JPH11113588A (ja) | 1997-10-09 | 1999-04-27 | Mitsubishi Chemical Corp | 含酸素化合物の製造方法 |
| JPH11196887A (ja) | 1998-01-16 | 1999-07-27 | Mitsubishi Chemical Corp | ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| JPH11196888A (ja) | 1998-01-16 | 1999-07-27 | Mitsubishi Chemical Corp | ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| EP0952221A2 (en) | 1998-03-18 | 1999-10-27 | Ajinomoto Co., Ltd. | L-Glutamic acid-producing bacterium and method for producing L-glutamic acid |
| EP0955368A2 (en) | 1998-03-18 | 1999-11-10 | Ajinomoto Co., Ltd. | L-glutamic acid-producing bacterium and method for producing l-glutamic acid |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| WO2000018935A1 (en) | 1998-09-25 | 2000-04-06 | Ajinomoto Co.,Inc. | Process for constructing amino acid-producing bacterium and process for producing amino acid by fermentation method with the use of the thus constructed amino acid-producing bacterium |
| US6303383B1 (en) | 1999-03-16 | 2001-10-16 | Ajinomoto Co., Inc. | Temperature sensitive plasmid for coryneform bacteria |
| WO2005010175A1 (en) | 2003-07-29 | 2005-02-03 | Ajinomoto Co., Inc. | Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity |
| JP2005058827A (ja) | 2003-08-15 | 2005-03-10 | Asano Koji Kk | 有機性汚水の処理方法 |
| WO2005021770A1 (ja) | 2003-08-28 | 2005-03-10 | Mitsubishi Chemical Corporation | コハク酸の製造方法 |
| US20050170482A1 (en) | 2003-11-14 | 2005-08-04 | Rice University | Aerobic succinate production in bacteria |
| WO2005052135A1 (en) | 2003-11-27 | 2005-06-09 | Korea Advanced Institute Of Science And Technology | Novel rumen bacteria variants and process for preparing succinic acid employing the same |
| US20070054387A1 (en) | 2003-11-27 | 2007-03-08 | Lee Sang Y | Novel rumen bacteria variants and process for preparing succinic acid employing the same |
| JP2005168401A (ja) | 2003-12-11 | 2005-06-30 | Mitsubishi Chemicals Corp | 非アミノ有機酸の製造方法 |
| WO2005116227A1 (en) | 2004-05-03 | 2005-12-08 | Ut-Battelle, Llc | A method to produce succinic acid from raw hydrolysates |
| WO2005113745A1 (ja) | 2004-05-20 | 2005-12-01 | Ajinomoto Co., Inc. | コハク酸生産菌及びコハク酸の製造方法 |
| WO2005113744A1 (ja) | 2004-05-20 | 2005-12-01 | Ajinomoto Co., Inc. | コハク酸生産菌及びコハク酸の製造方法 |
| WO2006031424A2 (en) | 2004-08-27 | 2006-03-23 | Rice University | Mutant e. coli strain with increased succinic acid production |
| JP2006180782A (ja) | 2004-12-27 | 2006-07-13 | Hiroshima Univ | バイオディーゼル廃液からの水素およびエタノールの製造方法、並びに当該方法を行なうためのキット |
| WO2006107127A1 (en) | 2005-04-08 | 2006-10-12 | Korea Advanced Institute Of Science And Technology | Method for improving a strain based on in-silico analysis |
| JP2006320208A (ja) | 2005-05-17 | 2006-11-30 | Mitsubishi Chemicals Corp | コハク酸の製造方法 |
| WO2007007933A1 (en) | 2005-07-11 | 2007-01-18 | Korea Advanced Institute Of Science And Technology | Method of in-silico improvement of organisms using the flux sum of metabolites |
| WO2007037460A1 (en) | 2005-09-27 | 2007-04-05 | Ajinomoto Co., Inc. | An l-amino acid-producing bacterium and a method for producing l-amino acids |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5644108B2 (ja) | 2014-12-24 |
| EP2241630B1 (en) | 2016-06-01 |
| JPWO2009072562A1 (ja) | 2011-04-28 |
| EP2241630A4 (en) | 2012-01-04 |
| US20100297716A1 (en) | 2010-11-25 |
| EP2241630A1 (en) | 2010-10-20 |
| US8247201B2 (en) | 2012-08-21 |
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