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WO2009071841A3 - Modulateurs de egr1 dans le traitement de l'alopécie - Google Patents

Modulateurs de egr1 dans le traitement de l'alopécie Download PDF

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Publication number
WO2009071841A3
WO2009071841A3 PCT/FR2008/052131 FR2008052131W WO2009071841A3 WO 2009071841 A3 WO2009071841 A3 WO 2009071841A3 FR 2008052131 W FR2008052131 W FR 2008052131W WO 2009071841 A3 WO2009071841 A3 WO 2009071841A3
Authority
WO
WIPO (PCT)
Prior art keywords
relates
gene
expression
determined
alopecia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/052131
Other languages
English (en)
Other versions
WO2009071841A2 (fr
Inventor
Sandrine Rethore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Priority to EP08858303A priority Critical patent/EP2242849A2/fr
Priority to CA2706672A priority patent/CA2706672A1/fr
Publication of WO2009071841A2 publication Critical patent/WO2009071841A2/fr
Publication of WO2009071841A3 publication Critical patent/WO2009071841A3/fr
Priority to US12/784,672 priority patent/US20100260736A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'alopécie, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité du facteur de transcription Early Growth Response 1 (EGRl), ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de ce facteur de transcription pour le traitement de l'alopécie. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de cette pathologie.
PCT/FR2008/052131 2007-11-26 2008-11-26 Modulateurs de egr1 dans le traitement de l'alopécie Ceased WO2009071841A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08858303A EP2242849A2 (fr) 2007-11-26 2008-11-26 Modulateurs de egr1 dans le traitement de l'alopécie
CA2706672A CA2706672A1 (fr) 2007-11-26 2008-11-26 Modulateurs de egr1 dans le traitement de l'alopecie
US12/784,672 US20100260736A1 (en) 2007-11-26 2010-05-21 Egr1 modulators for the treatment of alopecia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0759323 2007-11-26
FR0759323A FR2924128A1 (fr) 2007-11-26 2007-11-26 Modulateurs de egr1 dans le traitement de l'alopecie

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/784,672 Continuation US20100260736A1 (en) 2007-11-26 2010-05-21 Egr1 modulators for the treatment of alopecia

Publications (2)

Publication Number Publication Date
WO2009071841A2 WO2009071841A2 (fr) 2009-06-11
WO2009071841A3 true WO2009071841A3 (fr) 2009-10-15

Family

ID=39638956

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/052131 Ceased WO2009071841A2 (fr) 2007-11-26 2008-11-26 Modulateurs de egr1 dans le traitement de l'alopécie

Country Status (5)

Country Link
US (1) US20100260736A1 (fr)
EP (1) EP2242849A2 (fr)
CA (1) CA2706672A1 (fr)
FR (1) FR2924128A1 (fr)
WO (1) WO2009071841A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2519653A4 (fr) * 2009-12-31 2013-07-10 Univ Columbia Procédés pour la détection et la régulation de l'alopécie en aires, et de cohortes de gènes de celle-ci
FR3143040A1 (fr) * 2022-12-12 2024-06-14 L'oreal Méthode de pronostic et/ou de diagnostic d’une perte de densité capillaire

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062561A2 (fr) * 1998-06-02 1999-12-09 Glaxo Group Limited Methode de therapie genique
US20030124554A1 (en) * 1999-12-01 2003-07-03 Martin Braddock Screening method for compounds capable of modularing egr-1-regulated expression
WO2003057912A2 (fr) * 2002-01-07 2003-07-17 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Trichogramme moleculaire

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062561A2 (fr) * 1998-06-02 1999-12-09 Glaxo Group Limited Methode de therapie genique
US20030124554A1 (en) * 1999-12-01 2003-07-03 Martin Braddock Screening method for compounds capable of modularing egr-1-regulated expression
WO2003057912A2 (fr) * 2002-01-07 2003-07-17 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Trichogramme moleculaire

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"Abstracts for the 30th annual meeting of the Japanese Society for Investigative Dermatology, 20-22 April 2005, Yokohama, Japan", JOURNAL OF DERMATOLOGICAL SCIENCE, ELSEVIER SCIENCE PUBLISHERS, SHANNON, IR, vol. 38, no. 2, 1 May 2005 (2005-05-01), pages 113 - 165, XP025305575, ISSN: 0923-1811, [retrieved on 20050501] *
"External dermatologic composition for improving physiological fluid - comprises substituted phenyl compounds such as capsaicin, sinapine o curcumin, useful in cosmetics or pharmaceuticals for e.g. improving skin appearance or accelerating hair growth", DERWENT HOST- DERWENT, 1998, XP002265458 *
"Hair nourishing cosmetics - composed of e.g. curcumin, demethoxy-curcumin and/or bisdemethoxycurcumin fractionated from extract of Curcuma longa", DERWENT HOST- DERWENT, 1998, XP002338006 *
GOEL A ET AL: "Curcumin as ''Curecumin'': From kitchen to clinic", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 75, no. 4, 15 February 2008 (2008-02-15), pages 787 - 809, XP025743546, ISSN: 0006-2952, [retrieved on 20080215] *
HILLMER AXEL M ET AL: "Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 77, no. 1, 1 July 2005 (2005-07-01), pages 140 - 148, XP002490297, ISSN: 0002-9297, [retrieved on 20050518] *
MARTINEZ-MIR A ET AL: "Genetic linkage studies in alopecia areata", JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, CAMBRIDGE, US, vol. 8, no. 2, 1 October 2003 (2003-10-01), pages 199 - 203, XP002490295, ISSN: 1087-0024 *
MARTINEZ-MIR AMALIA ET AL: "Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 80, no. 2, 1 February 2007 (2007-02-01), pages 316 - 328, XP002490296, ISSN: 0002-9297 *

Also Published As

Publication number Publication date
US20100260736A1 (en) 2010-10-14
WO2009071841A2 (fr) 2009-06-11
CA2706672A1 (fr) 2009-06-11
FR2924128A1 (fr) 2009-05-29
EP2242849A2 (fr) 2010-10-27

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