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WO2009069727A1 - 生体高分子およびポリペプチドの化学修飾方法 - Google Patents

生体高分子およびポリペプチドの化学修飾方法 Download PDF

Info

Publication number
WO2009069727A1
WO2009069727A1 PCT/JP2008/071611 JP2008071611W WO2009069727A1 WO 2009069727 A1 WO2009069727 A1 WO 2009069727A1 JP 2008071611 W JP2008071611 W JP 2008071611W WO 2009069727 A1 WO2009069727 A1 WO 2009069727A1
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
biopolymer
chemically modifying
compound
chemically modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/071611
Other languages
English (en)
French (fr)
Inventor
Shouji Ooya
Tetsuo Hiratou
Kentaro Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Priority to JP2009543860A priority Critical patent/JP5497449B2/ja
Priority to US12/745,214 priority patent/US8507659B2/en
Priority to EP08854075.2A priority patent/EP2221334B1/en
Publication of WO2009069727A1 publication Critical patent/WO2009069727A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明の目的は、生体高分子あるいはポリペプチドを、疎水性の化合物又は塩基性条件下で分解や反応を起こす化合物で化学修飾する方法を提供することである。本発明によれば、有機フッ素化合物を含む反応溶液中において生体高分子又はポリペプチドを化学修飾することを特徴とする、化学修飾された生体高分子又はポリペプチドの製造方法が提供される。
PCT/JP2008/071611 2007-11-28 2008-11-28 生体高分子およびポリペプチドの化学修飾方法 Ceased WO2009069727A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009543860A JP5497449B2 (ja) 2007-11-28 2008-11-28 生体高分子およびポリペプチドの化学修飾方法
US12/745,214 US8507659B2 (en) 2007-11-28 2008-11-28 Method for chemically modifying biopolymer and polypeptide
EP08854075.2A EP2221334B1 (en) 2007-11-28 2008-11-28 Method for chemically modifying biopolymer and polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-307161 2007-11-28
JP2007307161 2007-11-28

Publications (1)

Publication Number Publication Date
WO2009069727A1 true WO2009069727A1 (ja) 2009-06-04

Family

ID=40678616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071611 Ceased WO2009069727A1 (ja) 2007-11-28 2008-11-28 生体高分子およびポリペプチドの化学修飾方法

Country Status (4)

Country Link
US (1) US8507659B2 (ja)
EP (1) EP2221334B1 (ja)
JP (1) JP5497449B2 (ja)
WO (1) WO2009069727A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012046717A1 (ja) * 2010-10-05 2012-04-12 独立行政法人物質・材料研究機構 2成分系組織接着剤及びその製造方法
WO2012046759A1 (ja) * 2010-10-05 2012-04-12 独立行政法人物質・材料研究機構 組織接着膜及びその製造方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019004909A (es) 2016-11-01 2019-08-12 Arrowhead Pharmaceuticals Inc Ligandos de integrina alfa-v beta-6 y usos de los mismos.
KR102762143B1 (ko) 2017-11-01 2025-02-07 애로우헤드 파마슈티컬스 인코포레이티드 인테그린 리간드 및 그의 용도
WO2022216920A1 (en) 2021-04-08 2022-10-13 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04189833A (ja) * 1990-11-16 1992-07-08 Takeda Chem Ind Ltd ケラチン有機溶媒液およびその製造法
JPH05214092A (ja) * 1991-10-21 1993-08-24 Ortho Pharmaceut Corp Ｐｅｇイミデート類およびそれらの蛋白質誘導体
EP1014176A2 (en) 1998-12-23 2000-06-28 Fuji Photo Film B.V. Silver halide emulsions containing recombinant gelatin-like proteins
JP2001224677A (ja) 1999-12-09 2001-08-21 Buaayu:Kk 光硬化性組織接着剤
JP2002531182A (ja) 1998-12-03 2002-09-24 ネアーリッヒ、ミヒャエル 多孔質複合マトリックス並びにその製造方法及び使用法
US6645712B1 (en) 1999-06-24 2003-11-11 Fuji Photo Film B.V. Oil-in-water emulsion stabilized with recombinant collagen-like material
EP1398324A1 (en) 2002-09-11 2004-03-17 Fuji Photo Film B.V. Use of recombinant gelatin-like proteins as plasma expanders and compositions suitable for plasma substitution
EP0926543B1 (en) 1997-12-24 2004-05-12 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
WO2004085473A2 (en) 2003-03-28 2004-10-07 Fuji Photo Film B.V. Rgd-enriched gelatine-like proteins with enhanced cell binding
JP2004532802A (ja) 2000-10-18 2004-10-28 ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション 薬剤送達および細胞被包における電気処理
JP2004321484A (ja) 2003-04-24 2004-11-18 Sangaku Renkei Kiko Kyushu:Kk 医療用高分子ナノ・マイクロファイバー
JP2006063283A (ja) * 2004-08-30 2006-03-09 Q P Corp 高分子組成物およびその製造方法、ならびに成形体
WO2008072379A1 (ja) * 2006-12-13 2008-06-19 Fujifilm Corporation 修飾された生体高分子の製造方法及び生体高分子の架橋方法

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* Cited by examiner, † Cited by third party
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US3097051A (en) * 1958-11-18 1963-07-09 Ricardo H Wade Cellulose ester anhydrides in fiber form
US4076870A (en) * 1975-10-01 1978-02-28 Daido-Maruta Finishing Co. Ltd. Process for treating fibrous products containing cellulosic fibers
US4745178A (en) * 1987-04-22 1988-05-17 Eli Lilly And Company Process for selective peptide bond cleavage using sulfoxides and CF3 CO
US5298243A (en) 1988-10-20 1994-03-29 Denki Kagaku Kogyo Kabushiki Kaisha Colony stimulating factor-gelatin conjugate
US5521097A (en) * 1991-08-28 1996-05-28 Seiko Instruments Inc. Method of determining amino acid sequence of protein or peptide from carboxy-terminal
US7256258B2 (en) * 2000-10-05 2007-08-14 Ares Trading S.A. Regioselective liquid phase pegylation
DE102004024635A1 (de) * 2004-05-12 2005-12-08 Deutsche Gelatine-Fabriken Stoess Ag Verfahren zur Herstellung von Formkörpern auf Basis von vernetzter Gelatine
US20060134170A1 (en) * 2004-08-13 2006-06-22 May Griffith Vision enhancing ophthalmic devices and related methods and compositions
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
US20070100091A1 (en) * 2005-10-31 2007-05-03 Anantharaman Dhanabalan Crosslinked poly(arylene ether) composition, method, and article

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04189833A (ja) * 1990-11-16 1992-07-08 Takeda Chem Ind Ltd ケラチン有機溶媒液およびその製造法
JPH05214092A (ja) * 1991-10-21 1993-08-24 Ortho Pharmaceut Corp Ｐｅｇイミデート類およびそれらの蛋白質誘導体
EP0926543B1 (en) 1997-12-24 2004-05-12 Fuji Photo Film B.V. Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof
JP2002531182A (ja) 1998-12-03 2002-09-24 ネアーリッヒ、ミヒャエル 多孔質複合マトリックス並びにその製造方法及び使用法
EP1014176A2 (en) 1998-12-23 2000-06-28 Fuji Photo Film B.V. Silver halide emulsions containing recombinant gelatin-like proteins
US6645712B1 (en) 1999-06-24 2003-11-11 Fuji Photo Film B.V. Oil-in-water emulsion stabilized with recombinant collagen-like material
JP2001224677A (ja) 1999-12-09 2001-08-21 Buaayu:Kk 光硬化性組織接着剤
JP2004532802A (ja) 2000-10-18 2004-10-28 ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション 薬剤送達および細胞被包における電気処理
EP1398324A1 (en) 2002-09-11 2004-03-17 Fuji Photo Film B.V. Use of recombinant gelatin-like proteins as plasma expanders and compositions suitable for plasma substitution
WO2004085473A2 (en) 2003-03-28 2004-10-07 Fuji Photo Film B.V. Rgd-enriched gelatine-like proteins with enhanced cell binding
JP2004321484A (ja) 2003-04-24 2004-11-18 Sangaku Renkei Kiko Kyushu:Kk 医療用高分子ナノ・マイクロファイバー
JP2006063283A (ja) * 2004-08-30 2006-03-09 Q P Corp 高分子組成物およびその製造方法、ならびに成形体
WO2008072379A1 (ja) * 2006-12-13 2008-06-19 Fujifilm Corporation 修飾された生体高分子の製造方法及び生体高分子の架橋方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2221334A4

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012046717A1 (ja) * 2010-10-05 2012-04-12 独立行政法人物質・材料研究機構 2成分系組織接着剤及びその製造方法
WO2012046759A1 (ja) * 2010-10-05 2012-04-12 独立行政法人物質・材料研究機構 組織接着膜及びその製造方法
JP5594633B2 (ja) * 2010-10-05 2014-09-24 独立行政法人物質・材料研究機構 ２成分系組織接着剤及びその製造方法
JP5747264B2 (ja) * 2010-10-05 2015-07-08 国立研究開発法人物質・材料研究機構 組織接着膜及びその製造方法
US9499728B2 (en) 2010-10-05 2016-11-22 National Institute For Materials Science Two-component tissue adhesive and method for producing same

Also Published As

Publication number Publication date
EP2221334A4 (en) 2011-08-24
JPWO2009069727A1 (ja) 2011-04-14
US20100323421A1 (en) 2010-12-23
EP2221334B1 (en) 2016-12-28
EP2221334A1 (en) 2010-08-25
US8507659B2 (en) 2013-08-13
JP5497449B2 (ja) 2014-05-21

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