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WO2009067657A3 - Methods of identifying molecular function - Google Patents

Methods of identifying molecular function Download PDF

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Publication number
WO2009067657A3
WO2009067657A3 PCT/US2008/084329 US2008084329W WO2009067657A3 WO 2009067657 A3 WO2009067657 A3 WO 2009067657A3 US 2008084329 W US2008084329 W US 2008084329W WO 2009067657 A3 WO2009067657 A3 WO 2009067657A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
molecular function
identifying molecular
identifying
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/084329
Other languages
French (fr)
Other versions
WO2009067657A2 (en
Inventor
Neal Woodbury
Matthew Greving
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona State University ASU
Original Assignee
Arizona State University ASU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arizona State University ASU filed Critical Arizona State University ASU
Publication of WO2009067657A2 publication Critical patent/WO2009067657A2/en
Publication of WO2009067657A3 publication Critical patent/WO2009067657A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)

Abstract

Disclosed herein are methods for identifying the molecular function of compounds, methods of iterative evolution of compounds, and a surface having high chemical diversity for performing the disclosed methods.
PCT/US2008/084329 2007-11-21 2008-11-21 Methods of identifying molecular function Ceased WO2009067657A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US404207P 2007-11-21 2007-11-21
US402307P 2007-11-21 2007-11-21
US61/004,042 2007-11-21
US61/004,023 2007-11-21

Publications (2)

Publication Number Publication Date
WO2009067657A2 WO2009067657A2 (en) 2009-05-28
WO2009067657A3 true WO2009067657A3 (en) 2009-12-30

Family

ID=40668095

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/084329 Ceased WO2009067657A2 (en) 2007-11-21 2008-11-21 Methods of identifying molecular function

Country Status (1)

Country Link
WO (1) WO2009067657A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11978534B1 (en) 2017-07-07 2024-05-07 Arizona Board Of Regents On Behalf Of Arizona State University Prediction of binding from binding data in peptide and other arrays
WO2020033271A1 (en) 2018-08-06 2020-02-13 Arizona Board Of Regents On Behalf Of Arizon State University Computational analysis to comprehensively predict and design molecular recognition between peptides and proteins

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082830A1 (en) * 1996-10-16 2003-05-01 Schreiber Stuart L. Synthesis of combinatorial libraries of compounds reminiscent of natural products
US20040048311A1 (en) * 2002-01-24 2004-03-11 Dana Ault-Riche Use of collections of binding sites for sample profiling and other applications
US20040163137A1 (en) * 2001-02-20 2004-08-19 Caroline Barry PG-3 and biallelic markers thereof
US20060210452A1 (en) * 1989-06-07 2006-09-21 Affymax Technologies, N.V., A Netherlands Antilles Corporation Very large scale immobilized polymer synthesis
US20070254289A1 (en) * 2005-10-26 2007-11-01 Applera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060210452A1 (en) * 1989-06-07 2006-09-21 Affymax Technologies, N.V., A Netherlands Antilles Corporation Very large scale immobilized polymer synthesis
US20030082830A1 (en) * 1996-10-16 2003-05-01 Schreiber Stuart L. Synthesis of combinatorial libraries of compounds reminiscent of natural products
US20040163137A1 (en) * 2001-02-20 2004-08-19 Caroline Barry PG-3 and biallelic markers thereof
US20040048311A1 (en) * 2002-01-24 2004-03-11 Dana Ault-Riche Use of collections of binding sites for sample profiling and other applications
US20070254289A1 (en) * 2005-10-26 2007-11-01 Applera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof

Also Published As

Publication number Publication date
WO2009067657A2 (en) 2009-05-28

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