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WO2009066503A1 - プローブアレイ用基体およびその製造方法ならびにプローブアレイおよびその製造方法 - Google Patents

プローブアレイ用基体およびその製造方法ならびにプローブアレイおよびその製造方法 Download PDF

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Publication number
WO2009066503A1
WO2009066503A1 PCT/JP2008/066705 JP2008066705W WO2009066503A1 WO 2009066503 A1 WO2009066503 A1 WO 2009066503A1 JP 2008066705 W JP2008066705 W JP 2008066705W WO 2009066503 A1 WO2009066503 A1 WO 2009066503A1
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WO
WIPO (PCT)
Prior art keywords
probe
producing
probe array
same
holding sections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/066705
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English (en)
French (fr)
Inventor
Teruhisa Shibahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Murata Manufacturing Co Ltd
Original Assignee
Murata Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Murata Manufacturing Co Ltd filed Critical Murata Manufacturing Co Ltd
Priority to JP2009542499A priority Critical patent/JP5182292B2/ja
Publication of WO2009066503A1 publication Critical patent/WO2009066503A1/ja
Priority to US12/779,276 priority patent/US8383057B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00373—Hollow needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0854—Double walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)

Abstract

　集積度が高く、十分な量のプローブ分子を保持でき、かつプローブ分子の量のばらつきの少ない、プローブアレイを構成するために適したプローブアレイ用基体を提供する。 　配列される複数のプローブ保持部（１０２）の各々を陥凹した形状によって与え、プローブ保持部（１０２）内に導入されるべきプローブ溶液の濡れ広がりを防止するため、隣り合うプローブ保持部（１０２）間に隔離溝（１１２）を形成する。プローブ保持部（１０２）の内面を親水性にしながら、隔離溝（１１２）の内面を疎水性にする。プローブ保持部（１０２）の内部に、液導入用突起（１０４）を形成する。
PCT/JP2008/066705 2007-11-22 2008-09-17 プローブアレイ用基体およびその製造方法ならびにプローブアレイおよびその製造方法 Ceased WO2009066503A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009542499A JP5182292B2 (ja) 2007-11-22 2008-09-17 プローブアレイ用基体ならびにプローブアレイおよびその製造方法
US12/779,276 US8383057B2 (en) 2007-11-22 2010-05-13 Probe array substrate and method for producing the same, and probe array and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-302573 2007-11-22
JP2007302573 2007-11-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/779,276 Continuation US8383057B2 (en) 2007-11-22 2010-05-13 Probe array substrate and method for producing the same, and probe array and method for producing the same

Publications (1)

Publication Number Publication Date
WO2009066503A1 true WO2009066503A1 (ja) 2009-05-28

Family

ID=40667331

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066705 Ceased WO2009066503A1 (ja) 2007-11-22 2008-09-17 プローブアレイ用基体およびその製造方法ならびにプローブアレイおよびその製造方法

Country Status (3)

Country Link
US (1) US8383057B2 (ja)
JP (1) JP5182292B2 (ja)
WO (1) WO2009066503A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011149853A (ja) * 2010-01-22 2011-08-04 Toppan Printing Co Ltd 分注方法及び分注装置
US20130037059A1 (en) * 2009-07-31 2013-02-14 Simon Stafford Means for improved liquid handling in a microplate
JP2014092529A (ja) * 2012-11-07 2014-05-19 Techno Medica Co Ltd センサーカード

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US8983019B2 (en) * 2010-08-31 2015-03-17 Massachusetts Institute Of Technology Superwetting surfaces for diminishing leidenfrost effect, methods of making and devices incorporating the same
ES2526243B1 (es) * 2013-07-05 2015-11-04 Carlos GARCÍA-OCHOA DEL FRESNO Dispositivo calefactor autónomo
FI128106B (en) * 2017-01-20 2019-09-30 Aalto Korkeakoulusaeaetioe Force indicator for surface wettability characterization

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WO2002025289A1 (en) * 2000-09-18 2002-03-28 I-Card Corporation Micro well array and method of sealing liquid using the micro well array
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JP2004045179A (ja) * 2002-07-11 2004-02-12 Nisshinbo Ind Inc マイクロアレイ用基材
WO2007080761A1 (ja) * 2006-01-10 2007-07-19 Murata Manufacturing Co., Ltd. プローブアレイ基体及びその製造方法、プローブアレイの製造方法

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EP0991930B1 (en) * 1997-06-26 2004-06-16 Perseptive Biosystems, Inc. High density sample holder for analysis of biological samples
JP3647369B2 (ja) 1999-10-22 2005-05-11 日本碍子株式会社 Ｄｎａチップ及びその製造方法
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WO2002025289A1 (en) * 2000-09-18 2002-03-28 I-Card Corporation Micro well array and method of sealing liquid using the micro well array
JP2004045179A (ja) * 2002-07-11 2004-02-12 Nisshinbo Ind Inc マイクロアレイ用基材
WO2007080761A1 (ja) * 2006-01-10 2007-07-19 Murata Manufacturing Co., Ltd. プローブアレイ基体及びその製造方法、プローブアレイの製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130037059A1 (en) * 2009-07-31 2013-02-14 Simon Stafford Means for improved liquid handling in a microplate
JP2011149853A (ja) * 2010-01-22 2011-08-04 Toppan Printing Co Ltd 分注方法及び分注装置
JP2014092529A (ja) * 2012-11-07 2014-05-19 Techno Medica Co Ltd センサーカード

Also Published As

Publication number Publication date
US8383057B2 (en) 2013-02-26
JP5182292B2 (ja) 2013-04-17
JPWO2009066503A1 (ja) 2011-04-07
US20100216668A1 (en) 2010-08-26

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