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WO2009065926A3 - Nouveaux composés anticancers - Google Patents

Nouveaux composés anticancers Download PDF

Info

Publication number
WO2009065926A3
WO2009065926A3 PCT/EP2008/065985 EP2008065985W WO2009065926A3 WO 2009065926 A3 WO2009065926 A3 WO 2009065926A3 EP 2008065985 W EP2008065985 W EP 2008065985W WO 2009065926 A3 WO2009065926 A3 WO 2009065926A3
Authority
WO
WIPO (PCT)
Prior art keywords
anticancer compounds
new anticancer
new
thiosulf
polysulf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/065985
Other languages
English (en)
Other versions
WO2009065926A2 (fr
Inventor
Anna Sparatore
Soldato Piero Del
Giancarlo Santus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sulfidris SRL
Original Assignee
Sulfidris SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sulfidris SRL filed Critical Sulfidris SRL
Publication of WO2009065926A2 publication Critical patent/WO2009065926A2/fr
Publication of WO2009065926A3 publication Critical patent/WO2009065926A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C07C381/04—Thiosulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés polysulfurés contenant 2 atomes de soufre ou plus qui appartiennent à la classe des thiosulfonates organiques ou des dérivés cycliques ou linéaires de dithioléthione ou au trithiocarbonates, destinées à être utilisés seuls ou en combinaison avec d'autres traitements anticancers pour le traitement et/ou la prévention du cancer et des maladies inflammatoires.
PCT/EP2008/065985 2007-11-22 2008-11-21 Nouveaux composés anticancers Ceased WO2009065926A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2007A002215 2007-11-22
ITMI20072215 ITMI20072215A1 (it) 2007-11-22 2007-11-22 Nuovi composti anticancro

Publications (2)

Publication Number Publication Date
WO2009065926A2 WO2009065926A2 (fr) 2009-05-28
WO2009065926A3 true WO2009065926A3 (fr) 2009-07-30

Family

ID=40314744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/065985 Ceased WO2009065926A2 (fr) 2007-11-22 2008-11-21 Nouveaux composés anticancers

Country Status (2)

Country Link
IT (1) ITMI20072215A1 (fr)
WO (1) WO2009065926A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201117095D0 (en) 2011-09-30 2011-11-16 Univ Exeter The Novel hydrogen sulfide releasing compounds
CN103012394B (zh) * 2012-11-19 2015-03-25 苏州大学 一种罗丹宁衍生物及其制备方法
US9919049B2 (en) 2014-06-02 2018-03-20 University Of Exeter Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use in photodynamic therapy
CN104744431A (zh) * 2015-03-06 2015-07-01 芜湖杨燕制药有限公司 一种组蛋白去乙酰化酶抑制剂及其制备方法和用途
US11230525B2 (en) 2016-07-15 2022-01-25 Sookmyung Womens University Industry-Academic Cooperation Foundation Organic sulfur compound, method for preparing same, and pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing same as active ingredient
CN108864040A (zh) * 2018-08-28 2018-11-23 西安交通大学 一类含1,2-二硫环戊烯-3-硫酮结构的硫化氢供体型化合物及其降血脂应用
CN111087426B (zh) * 2018-10-23 2021-02-02 成都贝诺科成生物科技有限公司 一种去甲基茴三硫衍生物及其制备方法和应用
EP4046632A1 (fr) 2021-02-23 2022-08-24 DMC Research Center, S.L. Propylpropane thiosulfonate pour l'utilisation dans le traitment du cancer

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE874447C (de) * 1944-08-22 1953-04-23 Bruno Dr Boettcher Verfahren zur Herstellung von 5-Thion-1, 2-dithiolen
US3931235A (en) * 1972-12-18 1976-01-06 The Dow Chemical Company Process for preparing sulfur-containing hydroxy pyrones
US3943176A (en) * 1972-12-29 1976-03-09 The Dow Chemical Company 2-(Sulfur-substituted)-3-hydroxy-5,5-dimethyl-2-cyclohexen-1-ones
US3976769A (en) * 1970-09-11 1976-08-24 Airwick Industries, Inc. Pesticidal compositions containing phosphoric esters and divalent sulphur compounds
US4197311A (en) * 1978-09-15 1980-04-08 American Cyanamid Company Cyanomethyl trithiocarbonate compounds useful as ovicidal agents
US4760078A (en) * 1986-03-05 1988-07-26 Mitsui Toatsu Chemicals Inc. Immunomodulator 1,2-dithiol-3-thione derivative composition, use method and process of producing the same
US6277617B1 (en) * 1996-11-26 2001-08-21 Genencor International, Inc. Chemically modified enzymes
US20020151570A1 (en) * 2000-12-15 2002-10-17 Oliver Kretschik Thiosulfonic acid S-esters as agents for protecting material
US20030220524A1 (en) * 2000-02-25 2003-11-27 Langler Richard Francis Sulfur containing compounds
EP0966304B1 (fr) * 1997-02-20 2005-05-25 David S. Dime Administration de medicament a specificite de site
US20060270635A1 (en) * 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE874447C (de) * 1944-08-22 1953-04-23 Bruno Dr Boettcher Verfahren zur Herstellung von 5-Thion-1, 2-dithiolen
US3976769A (en) * 1970-09-11 1976-08-24 Airwick Industries, Inc. Pesticidal compositions containing phosphoric esters and divalent sulphur compounds
US3931235A (en) * 1972-12-18 1976-01-06 The Dow Chemical Company Process for preparing sulfur-containing hydroxy pyrones
US3943176A (en) * 1972-12-29 1976-03-09 The Dow Chemical Company 2-(Sulfur-substituted)-3-hydroxy-5,5-dimethyl-2-cyclohexen-1-ones
US4197311A (en) * 1978-09-15 1980-04-08 American Cyanamid Company Cyanomethyl trithiocarbonate compounds useful as ovicidal agents
US4760078A (en) * 1986-03-05 1988-07-26 Mitsui Toatsu Chemicals Inc. Immunomodulator 1,2-dithiol-3-thione derivative composition, use method and process of producing the same
US6277617B1 (en) * 1996-11-26 2001-08-21 Genencor International, Inc. Chemically modified enzymes
EP0966304B1 (fr) * 1997-02-20 2005-05-25 David S. Dime Administration de medicament a specificite de site
US20030220524A1 (en) * 2000-02-25 2003-11-27 Langler Richard Francis Sulfur containing compounds
US20020151570A1 (en) * 2000-12-15 2002-10-17 Oliver Kretschik Thiosulfonic acid S-esters as agents for protecting material
US20060270635A1 (en) * 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BOLDYREW, DOKLADY AKADEMII NAUK SSSR, vol. 94, 1954, pages 877 *
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002527079, Database accession no. BRN 1740837 *
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002527080, Database accession no. BRN 1912441 *
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002527081, Database accession no. BRN 153879 *
E.PERRINO ET AL: "New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity1-23", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, 2008, pages 1893 - 1897, XP002527078 *
L.LI ET AL: "Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative", FREE RADICAL BIOLOGY & MEDICINE, vol. 42, 2007, pages 706 - 719, XP005878077 *
R.LUBET ET AL: "Chemopreventive efficacy of Anethole Trithione", INT.J.CANCER, vol. 72, 1997, pages 95 - 101, XP002237061 *
REDDY ET AL: "Chemoprevention of Colon Cancer by Thiol and other Organosulfur Compounds", ACS SYMPOSIUM SERIES, vol. 546, 1994, pages 164 - 172, XP009116458 *
SCHMITT ET AL, COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L'ACADEMIE DES SCIENCES, vol. 230, 1950, pages 1774 *
WEIDNER ET AL, JOURNAL OF MEDICINAL CHEMISTRY, vol. 7, 1964, pages 671 - 673 *

Also Published As

Publication number Publication date
ITMI20072215A1 (it) 2009-05-23
WO2009065926A2 (fr) 2009-05-28

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