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WO2009063505A3 - Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide - Google Patents

Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide Download PDF

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Publication number
WO2009063505A3
WO2009063505A3 PCT/IN2008/000647 IN2008000647W WO2009063505A3 WO 2009063505 A3 WO2009063505 A3 WO 2009063505A3 IN 2008000647 W IN2008000647 W IN 2008000647W WO 2009063505 A3 WO2009063505 A3 WO 2009063505A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxo
fluoro
morpholinyl
acetamide
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000647
Other languages
French (fr)
Other versions
WO2009063505A2 (en
Inventor
Dhananjay Govind Sathe
Nandu Baban Bhise
Avinash Vankatraman Naidu
Kamlesh Digambar Sawant
Anindya Sibnath Bhattacharyya
Tushar Anil Naik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pvt Ltd
Original Assignee
USV Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pvt Ltd filed Critical USV Pvt Ltd
Publication of WO2009063505A2 publication Critical patent/WO2009063505A2/en
Publication of WO2009063505A3 publication Critical patent/WO2009063505A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The present invention provides novel process for preparation of (S)-N-[[3-[3-Fluoro-4-(4- morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] -acetamide which comprises combining (R)-N-[3-[3-fluoro-4-morpholinyl phenyl]-2-oxo-5-oxazolidinyl]methylazide in suitable solvent, acetylating agent and acid in presence of a catalyst.
PCT/IN2008/000647 2007-10-08 2008-10-07 Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide Ceased WO2009063505A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2003MU2007 2007-10-08
IN2003/MUM/2007 2007-10-08

Publications (2)

Publication Number Publication Date
WO2009063505A2 WO2009063505A2 (en) 2009-05-22
WO2009063505A3 true WO2009063505A3 (en) 2009-11-12

Family

ID=40564952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000647 Ceased WO2009063505A2 (en) 2007-10-08 2008-10-07 Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide

Country Status (1)

Country Link
WO (1) WO2009063505A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011050826A1 (en) 2009-10-28 2011-05-05 Synthon B.V. Process for making crystalline form a of linezolid
US20130137864A1 (en) * 2009-12-26 2013-05-30 Jayaraman Venkat Raman Process for the preparation of linezolid
EP2603506A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
CN103140487A (en) 2010-08-11 2013-06-05 斯索恩有限公司 Process for making linezolid
HUE027158T2 (en) 2011-02-24 2016-08-29 Lee Pharma Ltd Novel process for preparation of linezolid and its novel intermediates
EP2683696A1 (en) 2011-03-09 2014-01-15 Synthon BV Process for making crystalline form a of linezolid
CN105461648B (en) * 2011-05-03 2018-01-12 江苏豪森药业集团有限公司 Crystal formation of Linezolid and preparation method thereof
CN102260222B (en) * 2011-05-20 2015-05-13 上海医药工业研究院 Linezolid crystal form V and preparation method thereof
CN102321040B (en) * 2011-07-14 2013-08-21 扬子江药业集团南京海陵药业有限公司 Method for preparing linezolid intermediate and linezolid
CN102321041B (en) * 2011-07-20 2013-09-25 华润赛科药业有限责任公司 Preparation method of linezolid
CN102993192B (en) * 2011-09-14 2016-06-08 南开大学 A kind of oxazolidinone compounds and its preparation method and application
WO2013072923A1 (en) 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
EP2852580A1 (en) * 2012-01-24 2015-04-01 Jubilant Life Sciences Ltd. Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
ITMI20120655A1 (en) * 2012-04-19 2013-10-20 Bioindustria Lab Italiano M Edicinali Spa PROCEDURE FOR THE PREPARATION OF LINEZOLID
WO2014045292A1 (en) * 2012-09-20 2014-03-27 Symed Labs Limited Improved process for the preparation of linezolid intermediate
ES2603252T3 (en) 2012-11-09 2017-02-24 Synthon Bv Process to prepare linezolid
CN105111160B (en) * 2015-09-11 2017-04-12 浙江新东港药业股份有限公司 Linezolid preparation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO2006110155A1 (en) * 2004-06-29 2006-10-19 Teva Pharmaceutical Industries Ltd Solid forms of linezolid and processes for preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO2006110155A1 (en) * 2004-06-29 2006-10-19 Teva Pharmaceutical Industries Ltd Solid forms of linezolid and processes for preparation thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERIC F. V. SCRIVEN, KENNETH TURNBULL: "Azides: Their Preparation and Synthetic Uses", CHEMICAL REVIEWS, vol. 88, no. 2, 1988, pages 297 - 368, XP002525610 *
LOHRAY B B ET AL: "A Short Synthesis of Oxazolidinone Derivatives Linezolid and Eperezolid: A New Class of Antibacterials", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 40, no. 26, 25 June 1999 (1999-06-25), pages 4855 - 4856, XP004168663, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
WO2009063505A2 (en) 2009-05-22

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