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WO2009063249A3 - Early detection of sepsis - Google Patents

Early detection of sepsis Download PDF

Info

Publication number
WO2009063249A3
WO2009063249A3 PCT/GB2008/051069 GB2008051069W WO2009063249A3 WO 2009063249 A3 WO2009063249 A3 WO 2009063249A3 GB 2008051069 W GB2008051069 W GB 2008051069W WO 2009063249 A3 WO2009063249 A3 WO 2009063249A3
Authority
WO
WIPO (PCT)
Prior art keywords
sepsis
early detection
pcr
infection
informative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2008/051069
Other languages
French (fr)
Other versions
WO2009063249A2 (en
Inventor
Timothy John Gilby Brooks
Matthew Christopher Jackson
Roman Antoni Lukaszewski
Martin Julian Pearce
Carrie Jane Turner
Amanda Marie Yates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Defence
Original Assignee
UK Secretary of State for Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Defence filed Critical UK Secretary of State for Defence
Publication of WO2009063249A2 publication Critical patent/WO2009063249A2/en
Publication of WO2009063249A3 publication Critical patent/WO2009063249A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a method for screening a biological sample to detect early stages of infection, SIRS or sepsis comprising the steps of detecting expression of a first set of informative biomarkers by RT-PCR and detecting expression of a second set of informative bio markers by RT-PCR; analysing the results of detection; classifying said sample according to the likelihood and/or timing of the development of overt infection.
PCT/GB2008/051069 2007-11-16 2008-11-17 Early detection of sepsis Ceased WO2009063249A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0722582.4 2007-11-16
GBGB0722582.4A GB0722582D0 (en) 2007-11-16 2007-11-16 Early detection of sepsis

Publications (2)

Publication Number Publication Date
WO2009063249A2 WO2009063249A2 (en) 2009-05-22
WO2009063249A3 true WO2009063249A3 (en) 2009-10-15

Family

ID=38896479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/051069 Ceased WO2009063249A2 (en) 2007-11-16 2008-11-17 Early detection of sepsis

Country Status (2)

Country Link
GB (2) GB0722582D0 (en)
WO (1) WO2009063249A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013107826A2 (en) * 2012-01-17 2013-07-25 Institut Pasteur Use of cellular biomarkers expression to diagnose sepsis among intensive care patients
CN105473743A (en) * 2013-06-28 2016-04-06 睿智研究实验室私人有限公司 Sepsis biomarkers and their applications
CN103882039B (en) * 2013-09-23 2016-04-20 中国农业科学院上海兽医研究所 Detect the fluorescent quantitative RT-PCR method of duck MAPK1 gene
CN107840876A (en) * 2016-09-18 2018-03-27 北京奥维亚生物技术有限公司 A kind of mouse Odf1 polypeptides and its preparation method for antibody
US20210325380A1 (en) * 2020-04-20 2021-10-21 EnLiSense, LLC Disease diagnostics using a multi-configurable sensing array

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044554A2 (en) * 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
WO2004087949A2 (en) * 2003-04-02 2004-10-14 Sirs-Lab Gmbh Method for recognising acute generalised inflammatory conditions (sirs), sepsis, sepsis-like conditions and systemic infections
WO2005095644A2 (en) * 2004-04-04 2005-10-13 Oligene Gmbh Method for recognizing signatures in complex gene expression profiles
WO2005106020A1 (en) * 2004-03-30 2005-11-10 Sirs-Lab Gmbh Method for the prediction of individual disease course in sepsis
WO2006061644A1 (en) * 2004-12-09 2006-06-15 Secretary Of State For Defence Early detection of sepsis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1742087A (en) * 2002-11-12 2006-03-01 贝克顿迪金森公司 Diagnosis of sepsis or SIRS using biomarker
JP2008538007A (en) * 2005-04-15 2008-10-02 ベクトン，ディッキンソン アンド カンパニー Diagnosis of sepsis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044554A2 (en) * 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
WO2004087949A2 (en) * 2003-04-02 2004-10-14 Sirs-Lab Gmbh Method for recognising acute generalised inflammatory conditions (sirs), sepsis, sepsis-like conditions and systemic infections
WO2005106020A1 (en) * 2004-03-30 2005-11-10 Sirs-Lab Gmbh Method for the prediction of individual disease course in sepsis
WO2005095644A2 (en) * 2004-04-04 2005-10-13 Oligene Gmbh Method for recognizing signatures in complex gene expression profiles
WO2006061644A1 (en) * 2004-12-09 2006-06-15 Secretary Of State For Defence Early detection of sepsis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHINNAIYAN A M ET AL: "MOLECULAR SIGNATURES OF SEPSIS MULTIORGAN GENE EXPRESSION PROFILES OF SYSTEMIC INFLAMMATION", AMERICAN JOURNAL OF PATHOLOGY, AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 159, no. 4, 1 October 2001 (2001-10-01), pages 1199 - 1209, XP008037039, ISSN: 0002-9440 *
COBB J P ET AL: "SEPSIS GENE EXPRESSION PROFILING: MURINE SPLENIC COMPARED WITH HEPATIC RESPONSES DETERMINED BY USING COMPLEMENTARY DNA MICROARRAYS", CRITICAL CARE MEDICINE, WILLIAMS AND WILKINGS COMPANY, BALTIMORE, MA, US, vol. 30, no. 12, 1 December 2002 (2002-12-01), pages 2711 - 2721, XP008037048, ISSN: 0090-3493 *
PRUCHA M ET AL: "EXPRESSION PROFILING: TOWARD AN APPLICATION IN SEPSIS DIAGNOSTICS", SHOCK, XX, XX, vol. 22, no. 1, 1 July 2004 (2004-07-01), pages 29 - 33, XP008036997 *
TAKALA A ET AL: "MARKERS OF INFLAMMATION IN SEPSIS", ANNALS OF MEDICINE, FINNISH MEDICAL SOCIETY DUODECIM, HELSINKI, FI, vol. 34, no. 7-08, 1 October 2002 (2002-10-01), pages 614 - 623, XP009055727, ISSN: 0785-3890 *

Also Published As

Publication number Publication date
WO2009063249A2 (en) 2009-05-22
GB2454799A (en) 2009-05-20
GB0820899D0 (en) 2008-12-24
GB0722582D0 (en) 2007-12-27

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