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WO2009063069A3 - Protein purification and endotoxin removal - Google Patents

Protein purification and endotoxin removal Download PDF

Info

Publication number
WO2009063069A3
WO2009063069A3 PCT/EP2008/065595 EP2008065595W WO2009063069A3 WO 2009063069 A3 WO2009063069 A3 WO 2009063069A3 EP 2008065595 W EP2008065595 W EP 2008065595W WO 2009063069 A3 WO2009063069 A3 WO 2009063069A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein purification
endotoxin removal
endotoxin
removal
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/065595
Other languages
French (fr)
Other versions
WO2009063069A2 (en
Inventor
Rikke Christina Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to EP08849938A priority Critical patent/EP2220108A2/en
Publication of WO2009063069A2 publication Critical patent/WO2009063069A2/en
Publication of WO2009063069A3 publication Critical patent/WO2009063069A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2257—Prolactin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to a process for purifying peptides, in particular but not exclusively, to a process for removing endotoxins from a peptide solution, to a kit comprising reagents for said process and to the purified peptide obtained by said process.
PCT/EP2008/065595 2007-11-15 2008-11-14 Endotoxin removal Ceased WO2009063069A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08849938A EP2220108A2 (en) 2007-11-15 2008-11-14 Protein purification and endotoxin removal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07022183.3 2007-11-15
EP07022183 2007-11-15

Publications (2)

Publication Number Publication Date
WO2009063069A2 WO2009063069A2 (en) 2009-05-22
WO2009063069A3 true WO2009063069A3 (en) 2010-02-25

Family

ID=40568529

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/065595 Ceased WO2009063069A2 (en) 2007-11-15 2008-11-14 Endotoxin removal

Country Status (2)

Country Link
EP (1) EP2220108A2 (en)
WO (1) WO2009063069A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2732423A1 (en) 2008-08-21 2010-02-25 Octapharma Ag Recombinantly produced human factor viii and ix
ES2596727T3 (en) * 2010-03-30 2017-01-11 Octapharma Ag Purification procedure of a G-CSF protein growth factor
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153265A (en) * 1988-01-20 1992-10-06 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
WO1999063076A1 (en) * 1998-06-01 1999-12-09 The Immune Response Corporation Novel method of large scale plasmid purification

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153265A (en) * 1988-01-20 1992-10-06 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
WO1999063076A1 (en) * 1998-06-01 1999-12-09 The Immune Response Corporation Novel method of large scale plasmid purification

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANSPACH F B ET AL: "Removal of endotoxins by affinity sorbents", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 711, no. 1, 8 September 1995 (1995-09-08), pages 81 - 92, XP004038953, ISSN: 0021-9673 *
NEIDHARDT E A ET AL: "Rapid, two-step purification process for the preparation of pyrogen-free murine immunoglobulin G1 monoclonal antibodies", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 590, no. 2, 31 January 1992 (1992-01-31), pages 255 - 261, XP026538910, ISSN: 0021-9673, [retrieved on 19920131] *

Also Published As

Publication number Publication date
EP2220108A2 (en) 2010-08-25
WO2009063069A2 (en) 2009-05-22

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