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WO2009057695A1 - 遺伝子解析による腺腫又はがんの検出方法 - Google Patents

遺伝子解析による腺腫又はがんの検出方法 Download PDF

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Publication number
WO2009057695A1
WO2009057695A1 PCT/JP2008/069757 JP2008069757W WO2009057695A1 WO 2009057695 A1 WO2009057695 A1 WO 2009057695A1 JP 2008069757 W JP2008069757 W JP 2008069757W WO 2009057695 A1 WO2009057695 A1 WO 2009057695A1
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WO
WIPO (PCT)
Prior art keywords
adenoma
cancer
sample
detection
genetic analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/069757
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English (en)
French (fr)
Inventor
Tamao Akesaka
Tomonori Nagaoka
Shigeru Kanaoka
Kenichi Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Hamamatsu University School of Medicine NUC
Original Assignee
Olympus Corp
Hamamatsu University School of Medicine NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp, Hamamatsu University School of Medicine NUC filed Critical Olympus Corp
Priority to US12/740,283 priority Critical patent/US20100255481A1/en
Priority to JP2009539105A priority patent/JPWO2009057695A1/ja
Publication of WO2009057695A1 publication Critical patent/WO2009057695A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

本発明においては、容易に採取可能な試料について生物学的マーカーの遺伝子発現解析を行うことにより、腺腫・がんの早期検出を可能にする方法を提供することを課題としている。本発明は、被験者から採取した体液試料又は排泄物試料中に含まれる、少なくとも一のハウスキーピング遺伝子又はその発現産物を構成する配列の量を測定して、試料中の当該配列の濃度を算出する工程を含む、腺腫・がん検出方法を提供する。
PCT/JP2008/069757 2007-10-30 2008-10-30 遺伝子解析による腺腫又はがんの検出方法 Ceased WO2009057695A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/740,283 US20100255481A1 (en) 2007-10-30 2008-10-30 Method for detection of adenoma or cancer by genetic analysis
JP2009539105A JPWO2009057695A1 (ja) 2007-10-30 2008-10-30 遺伝子解析による腺腫又はがんの検出方法

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007282044 2007-10-30
JP2007-282044 2007-10-30
JP2008-222748 2008-08-29
JP2008222748 2008-08-29
JP2008252649 2008-09-30
JP2008-252649 2008-09-30

Publications (1)

Publication Number Publication Date
WO2009057695A1 true WO2009057695A1 (ja) 2009-05-07

Family

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Family Applications (1)

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PCT/JP2008/069757 Ceased WO2009057695A1 (ja) 2007-10-30 2008-10-30 遺伝子解析による腺腫又はがんの検出方法

Country Status (3)

Country Link
US (1) US20100255481A1 (ja)
JP (1) JPWO2009057695A1 (ja)
WO (1) WO2009057695A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
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JP2013528063A (ja) * 2010-06-11 2013-07-08 日立化成株式会社 腎機能の特徴を決定する方法
JP2014035186A (ja) * 2012-08-07 2014-02-24 Kitasato Institute 膀胱癌診断用ポリペプチドマーカー及び膀胱癌診断用キット並びにこれらを使用する方法
US9458496B2 (en) 2010-06-11 2016-10-04 Hitachi Chemical Company, Ltd. Method of characterizing vascular diseases
EP2513330B1 (en) * 2009-12-17 2017-03-08 Genome Research Limited Diagnostic methods based on somatically acquired rearrangement
JP2017508464A (ja) * 2014-03-03 2017-03-30 インスティトゥート ディンベスティガシオ ビオメディカ デ ジローナ ドクトル ジュゼップ トルエタ 定量的ｐｃｒによってヒトの糞便試料から大腸癌を診断する方法、プライマー及びキット
US9662649B2 (en) 2013-05-06 2017-05-30 Hitachi Chemical Company America, Ltd. Devices and methods for capturing target molecules
US9719129B2 (en) 2011-06-10 2017-08-01 Hitachi Chemical Co., Ltd. Methods for isolating vesicles from biological fluids
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US10370719B2 (en) 2014-11-12 2019-08-06 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease

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EP1772522A1 (en) * 2005-10-04 2007-04-11 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Control of preservation by biomarkers
AU2012273121B2 (en) 2011-06-19 2016-08-25 Abogen, Inc. Devices, solutions and methods for sample collection
IL247662B2 (en) 2014-03-07 2025-02-01 Dna Genotek Inc Composition and method for stabilizing nucleic acids in biological samples

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2513330B1 (en) * 2009-12-17 2017-03-08 Genome Research Limited Diagnostic methods based on somatically acquired rearrangement
JP2013528063A (ja) * 2010-06-11 2013-07-08 日立化成株式会社 腎機能の特徴を決定する方法
US9458496B2 (en) 2010-06-11 2016-10-04 Hitachi Chemical Company, Ltd. Method of characterizing vascular diseases
US9719129B2 (en) 2011-06-10 2017-08-01 Hitachi Chemical Co., Ltd. Methods for isolating vesicles from biological fluids
US9790542B2 (en) 2011-06-10 2017-10-17 Hitachi Chemical Co., Ltd. Methods for isolation of biomarkers from vesicles
JP2014035186A (ja) * 2012-08-07 2014-02-24 Kitasato Institute 膀胱癌診断用ポリペプチドマーカー及び膀胱癌診断用キット並びにこれらを使用する方法
US9662649B2 (en) 2013-05-06 2017-05-30 Hitachi Chemical Company America, Ltd. Devices and methods for capturing target molecules
US10697001B2 (en) 2013-05-06 2020-06-30 Hitachi Chemical Co., Ltd. Devices and methods for capturing target molecules
JP2017508464A (ja) * 2014-03-03 2017-03-30 インスティトゥート ディンベスティガシオ ビオメディカ デ ジローナ ドクトル ジュゼップ トルエタ 定量的ｐｃｒによってヒトの糞便試料から大腸癌を診断する方法、プライマー及びキット
JP2020146052A (ja) * 2014-03-03 2020-09-17 フンダシオ インスティトゥート ディンベスティガシオ ビオメディカ デ ジローナ ドクトル ジュゼップ トルエタ 定量的ｐｃｒによってヒトの糞便試料から大腸癌を診断する方法、プライマー及びキット
US10927416B2 (en) 2014-03-03 2021-02-23 Fundació Institut D'investigació Biomèdica De Girona Dr. Josep Trueta Method for diagnosing colorectal cancer from a human feces sample by quantitative PCR, primers and kit
JP7053146B2 (ja) 2014-03-03 2022-04-12 フンダシオ インスティトゥート ディンベスティガシオ ビオメディカ デ ジローナ ドクトル ジュゼップ トルエタ 定量的ｐｃｒによってヒトの糞便試料から大腸癌を診断する方法、プライマー及びキット
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US10370719B2 (en) 2014-11-12 2019-08-06 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease

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JPWO2009057695A1 (ja) 2011-03-10
US20100255481A1 (en) 2010-10-07

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