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WO2009056811A3 - Tetrahydrobenzothiazole derivatives with dopamine receptor activity - Google Patents

Tetrahydrobenzothiazole derivatives with dopamine receptor activity Download PDF

Info

Publication number
WO2009056811A3
WO2009056811A3 PCT/GB2008/003643 GB2008003643W WO2009056811A3 WO 2009056811 A3 WO2009056811 A3 WO 2009056811A3 GB 2008003643 W GB2008003643 W GB 2008003643W WO 2009056811 A3 WO2009056811 A3 WO 2009056811A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor activity
dopamine receptor
tetrahydrobenzothiazole
derivatives
tetrahydrobenzothiazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2008/003643
Other languages
French (fr)
Other versions
WO2009056811A2 (en
Inventor
Holger Stark
Jukka Matti Leppanen
Britta Caroline Sasse
Oliver Saur
Tim Kottke
Michael Peter Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Motac Neuroscience Ltd
Original Assignee
Motac Neuroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Motac Neuroscience Ltd filed Critical Motac Neuroscience Ltd
Publication of WO2009056811A2 publication Critical patent/WO2009056811A2/en
Publication of WO2009056811A3 publication Critical patent/WO2009056811A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of the following formula is described (I), wherein X, Y, R1 and R are as defined in the text and wherein the compounds are intended for use in treating medical conditions characterized by an imbalance in dopamine receptor activity.
PCT/GB2008/003643 2007-10-31 2008-10-28 Medicaments Ceased WO2009056811A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0721333.3 2007-10-31
GBGB0721333.3A GB0721333D0 (en) 2007-10-31 2007-10-31 Medicaments

Publications (2)

Publication Number Publication Date
WO2009056811A2 WO2009056811A2 (en) 2009-05-07
WO2009056811A3 true WO2009056811A3 (en) 2009-10-15

Family

ID=38834565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/003643 Ceased WO2009056811A2 (en) 2007-10-31 2008-10-28 Medicaments

Country Status (2)

Country Link
GB (1) GB0721333D0 (en)
WO (1) WO2009056811A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010025235A1 (en) * 2008-08-29 2010-03-04 Regents Of The University Of Michigan Selective ligands for the dopamine 3 (d3) receptor and methods of using the same
EP2446756B2 (en) * 2010-10-29 2021-11-10 British American Tobacco (Investments) Limited Method and apparatus for introducing additives to smokeless tobacco products

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186087A1 (en) * 1984-12-22 1986-07-02 Dr. Karl Thomae GmbH Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
EP0251077A1 (en) * 1986-06-21 1988-01-07 Boehringer Ingelheim Kg Tetrahydrobenzothiazoles, their preparation and use
WO1996028157A1 (en) * 1995-03-14 1996-09-19 Laboratoires Jacques Logeais Pharmaceutical compositions containing l-etrabamine, uses thereof, and methods for preparing same
WO1997045403A1 (en) * 1996-05-31 1997-12-04 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine d3 ligands
US20050020645A1 (en) * 2001-06-20 2005-01-27 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
WO2005092871A2 (en) * 2004-03-19 2005-10-06 Dipharma S.P.A. Intermediates for the preparation of pramipexole
US20060063704A1 (en) * 2003-04-11 2006-03-23 Dong Zheng X Somatostatin-dopamine chimeric analogs
WO2007022182A1 (en) * 2005-08-15 2007-02-22 University Of Virginia Patent Foundation Neurorestoration with r(+) pramipexole
WO2008012010A1 (en) * 2006-07-27 2008-01-31 Ucb Pharma, S.A. Fused oxazoles & thiazoles as histamine h3- receptor ligands
WO2008086353A1 (en) * 2007-01-08 2008-07-17 Zurawski Vincent R Jr Propargyl-containing derivatives of tetrahydro-benzthiazoles and methods of making and using the same
WO2008086047A1 (en) * 2007-01-03 2008-07-17 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
WO2008128961A1 (en) * 2007-04-20 2008-10-30 Glaxo Group Limited Compounds

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186087A1 (en) * 1984-12-22 1986-07-02 Dr. Karl Thomae GmbH Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
EP0251077A1 (en) * 1986-06-21 1988-01-07 Boehringer Ingelheim Kg Tetrahydrobenzothiazoles, their preparation and use
WO1996028157A1 (en) * 1995-03-14 1996-09-19 Laboratoires Jacques Logeais Pharmaceutical compositions containing l-etrabamine, uses thereof, and methods for preparing same
WO1997045403A1 (en) * 1996-05-31 1997-12-04 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine d3 ligands
US20050020645A1 (en) * 2001-06-20 2005-01-27 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
US20060063704A1 (en) * 2003-04-11 2006-03-23 Dong Zheng X Somatostatin-dopamine chimeric analogs
WO2005092871A2 (en) * 2004-03-19 2005-10-06 Dipharma S.P.A. Intermediates for the preparation of pramipexole
WO2007022182A1 (en) * 2005-08-15 2007-02-22 University Of Virginia Patent Foundation Neurorestoration with r(+) pramipexole
WO2008012010A1 (en) * 2006-07-27 2008-01-31 Ucb Pharma, S.A. Fused oxazoles & thiazoles as histamine h3- receptor ligands
WO2008086047A1 (en) * 2007-01-03 2008-07-17 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
WO2008086353A1 (en) * 2007-01-08 2008-07-17 Zurawski Vincent R Jr Propargyl-containing derivatives of tetrahydro-benzthiazoles and methods of making and using the same
WO2008128961A1 (en) * 2007-04-20 2008-10-30 Glaxo Group Limited Compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAILLARD J ET AL: "SYNTHESE DE DERIVES AMINES DU TETRAHYDRO-4,5,6,7 BENZOTHIAZOLE I. ÖAMINES ET N-METHYLAMINES EN POSITIONS 4,5,6 ET 7 A ACTIVITE DOPAMINERGIQUE CENTRALE", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 19, no. 5, 1 January 1984 (1984-01-01), pages 451 - 456, XP000578112, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
WO2009056811A2 (en) 2009-05-07
GB0721333D0 (en) 2007-12-12

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