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WO2009049574A1 - Granulat enduit pour la régénération osseuse - Google Patents

Granulat enduit pour la régénération osseuse Download PDF

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Publication number
WO2009049574A1
WO2009049574A1 PCT/DE2008/000101 DE2008000101W WO2009049574A1 WO 2009049574 A1 WO2009049574 A1 WO 2009049574A1 DE 2008000101 W DE2008000101 W DE 2008000101W WO 2009049574 A1 WO2009049574 A1 WO 2009049574A1
Authority
WO
WIPO (PCT)
Prior art keywords
granules
collagen
bone
human
jaw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2008/000101
Other languages
German (de)
English (en)
Inventor
Antonis Alexakis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP08715436A priority Critical patent/EP2211782A1/fr
Publication of WO2009049574A1 publication Critical patent/WO2009049574A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A61F2002/30064—Coating or prosthesis-covering structure made of biodegradable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00347—Nacre or mother-of-pearl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A61F2310/00982—Coating made of collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to a coated granule for promoting bone formation according to the preamble of claim 1.
  • the cavity required for the targeted growth of the osteoblasts on the human or animal jawbone is formed by resorbable granules.
  • the invention has for its object to propose a fundamentally novel granules. This object is achieved with the features of claim 1. Advantageous developments of the invention are specified in the subclaims.
  • the invention is based on the idea to form the body completely resorbable granules permanently dimensionally stable.
  • the granulate according to the invention is preferably produced as a mass product in different grain sizes.
  • the grains are formed in such a way that they can be applied to the corresponding body parts without having to use changes.
  • Another advantage of the granules according to the invention is the coating.
  • Advantage 1 The coating absorbs the patient's blood and thus body cells are available at any height and depth. In this way, vessels can grow at the same time in the entire cavity, which are important for the osteoblasts to be able to feed themselves and to form new bones.
  • the filled-up or built-up granules stick to the existing bone backing or tooth root, which also facilitates regeneration.
  • the coating material has a
  • Adhesive property by which the introduced granules can be fixed at a predetermined position on the body.
  • collagen is used as the coating material, in particular a mixture of collagen 1 and collagen 3.
  • collagen it is also conceivable to use only collagen 1 or exclusively collagen 3.
  • Collagen not only has sealing properties, but fixes the molding at least temporarily by its adhesive effect.
  • the granules contain allogeneic material or consist entirely of allogenic material.
  • the use of FDBA (freeze-dried bone allacrafts) or of DFDBA (decalcified freeze-dried bone allocrafts) is advantageous.
  • FDBA freeze-dried bone allacrafts
  • DFDBA decalcified freeze-dried bone allocrafts
  • xenogenic materials for the production of granules has proven to be advantageous. Bones of beef, pork, and horse are particularly suitable for the production of moldings which are suitable for humans. However, it is also possible to produce the granules from algae, in particular algae extracts, corals or mussels.
  • the shell of mussels are particularly suitable for the production of granules, since it consists of a calcium-protein mixture and can be absorbed particularly well by the body.
  • the likelihood of occurrence of inflammatory reactions of the body of the patient is the lowest.
  • Fig. 1 shows a bone defect which is filled with the coated granules.
  • Fig.l the granules 3 is shown in section. It forms above the jaw bone 1 from a cavity 4, in the first fibroblasts and then the osteoblasts of the jawbone 1 in the direction of arrow 5 can grow. To prevent cells of the periosteum 6 or cells of the gum 7 from penetrating into the cavity 4, the granules 3 are sealed against the tooth 2 and against the jawbone 1 by means of collagen 8.
  • the granulate 3 consists of a shell granulate which can be adapted via the collagen coating to the special situation on the body of the patient.
  • the upper gingival flap 7 is first opened.
  • the surface of the jawbone is roughened to promote the growth of the bone 1.
  • the granules 3 with its collagen coating 8 applied to the appropriate place on the jaw bone 1 and / or 2 tooth fixed.
  • the gingival flap 7 is then folded back into the position shown in FIG. 1 and fixed on the outside of the granulate 3.
  • the periosteum 6 grows along in the direction of the arrow 10, so that after some time the original jaw situation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)

Abstract

L'invention concerne un granulat (3) enduit qui contribue à la régénération osseuse, notamment dans la mâchoire. Ce granulat (3) est constitué d'un matériau pouvant se résorber dans le corps humain ou animal et il présente une forme qui remplit les cavités d'un substrat osseux (1) humain ou animal.
PCT/DE2008/000101 2007-10-18 2008-01-22 Granulat enduit pour la régénération osseuse Ceased WO2009049574A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08715436A EP2211782A1 (fr) 2007-10-18 2008-01-22 Granulat enduit pour la régénération osseuse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007050440.5 2007-10-18
DE200710050440 DE102007050440A1 (de) 2007-10-18 2007-10-18 Beschichtetes Granulat zur Neubildung von Knochenmaterial

Publications (1)

Publication Number Publication Date
WO2009049574A1 true WO2009049574A1 (fr) 2009-04-23

Family

ID=39820932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2008/000101 Ceased WO2009049574A1 (fr) 2007-10-18 2008-01-22 Granulat enduit pour la régénération osseuse

Country Status (3)

Country Link
EP (1) EP2211782A1 (fr)
DE (1) DE102007050440A1 (fr)
WO (1) WO2009049574A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010130409A3 (fr) * 2009-05-11 2011-05-05 Antonis Alexakis Granulat pour reconstituer une matière osseuse

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009042493B4 (de) * 2009-09-14 2016-07-21 Celgen3D Ag Granulatmischung, umfassend zwei verschiedene Granulate, zur künstlichen Kallusdistraktion
DE102011119909A1 (de) * 2011-12-01 2013-06-06 Antonis Alexakis Regenerations Hilfe für Knochendefekte

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3925185A1 (de) * 1988-09-27 1990-05-23 Technisches Glas Veb K Verfahren zur herstellung eines osteoinduktiven knochenersatzmaterials
WO1997034645A1 (fr) * 1996-03-15 1997-09-25 Johnson & Johnson Medical Limited Billes enrobees bio-absorbables pour le traitement de plaies
WO2002083194A1 (fr) * 2001-04-12 2002-10-24 Therics, Inc. Procede et appareil destines a des biostructures de regeneration techniques
DE102005060761A1 (de) * 2005-12-16 2007-06-21 Alexakis, Antonis, Dr. med. dent. Formteil zur Neubildung von Knochenmaterial

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
DE3542744C1 (de) * 1985-12-03 1987-05-27 Ewers Rolf Poroeses Hydroxylapatit-Material
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
DE4302708C2 (de) * 1993-02-01 1995-06-01 Kirsch Axel Abdeckmembran
DE19520867C2 (de) * 1995-06-08 1998-05-20 Kirsch Axel Abdeckmembran
SE514908C2 (sv) * 1998-07-13 2001-05-14 Gs Dev Ab Medel för benrekonstruktion
US6696073B2 (en) * 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
DE202004018682U1 (de) * 2004-12-03 2005-02-03 Lang, Manfred, Prof. Dr.med.dent. Knochenregenerations-Basiswerkstoff zur Augmentation im Ober- und Unterkiefer
WO2006086783A2 (fr) * 2005-02-11 2006-08-17 The Regents Of The University Of California Obtention de materiaux synthetiques pour implants et autres structures et dispositifs par conversion de coquilles marines et autres materiaux a base de calcite et d'aragonite a structure dense
DE102005040848A1 (de) * 2005-08-29 2007-03-01 Artoss Gmbh Osteoinduktives Material und Verfahren zur Herstellung desselben

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3925185A1 (de) * 1988-09-27 1990-05-23 Technisches Glas Veb K Verfahren zur herstellung eines osteoinduktiven knochenersatzmaterials
WO1997034645A1 (fr) * 1996-03-15 1997-09-25 Johnson & Johnson Medical Limited Billes enrobees bio-absorbables pour le traitement de plaies
WO2002083194A1 (fr) * 2001-04-12 2002-10-24 Therics, Inc. Procede et appareil destines a des biostructures de regeneration techniques
DE102005060761A1 (de) * 2005-12-16 2007-06-21 Alexakis, Antonis, Dr. med. dent. Formteil zur Neubildung von Knochenmaterial

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2211782A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010130409A3 (fr) * 2009-05-11 2011-05-05 Antonis Alexakis Granulat pour reconstituer une matière osseuse

Also Published As

Publication number Publication date
EP2211782A1 (fr) 2010-08-04
DE102007050440A1 (de) 2009-04-23

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