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WO2009048532A3 - Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation - Google Patents

Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation Download PDF

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Publication number
WO2009048532A3
WO2009048532A3 PCT/US2008/011456 US2008011456W WO2009048532A3 WO 2009048532 A3 WO2009048532 A3 WO 2009048532A3 US 2008011456 W US2008011456 W US 2008011456W WO 2009048532 A3 WO2009048532 A3 WO 2009048532A3
Authority
WO
WIPO (PCT)
Prior art keywords
emulsions
particles
formation
preparation
drug release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/011456
Other languages
French (fr)
Other versions
WO2009048532A2 (en
Inventor
Howard A. Stone
Jiandi Wan
Matthew Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of WO2009048532A2 publication Critical patent/WO2009048532A2/en
Publication of WO2009048532A3 publication Critical patent/WO2009048532A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention generally relates to emulsions and, in particular, to systems and methods for forming multiple emulsions and emulsions produced therefrom. A multiple emulsion generally describes a larger droplet that contains one or more smaller droplets therein which, in some cases, can contain even smaller droplets therein, etc. Multiple emulsions can be formed in certain embodiments with generally precise repeatability, and can be tailored to include any number of inner droplets, in any desired nesting arrangement, within a single outer droplet. In some cases, one (or more) of the fluids can be a gas. In addition, in some embodiments, the size of the multiple emulsion can be varied.
PCT/US2008/011456 2007-10-05 2008-10-03 Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation Ceased WO2009048532A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99799407P 2007-10-05 2007-10-05
US60/997,994 2007-10-05

Publications (2)

Publication Number Publication Date
WO2009048532A2 WO2009048532A2 (en) 2009-04-16
WO2009048532A3 true WO2009048532A3 (en) 2009-09-24

Family

ID=40430250

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/011456 Ceased WO2009048532A2 (en) 2007-10-05 2008-10-03 Formation of particles for ultrasound application, drug release, and other uses, and microfluidic methods of preparation

Country Status (1)

Country Link
WO (1) WO2009048532A2 (en)

Cited By (1)

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CN102892704A (en) * 2010-03-30 2013-01-23 巴黎综合理工学院 Apparatus for droplet formation in microfluidic circuits

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US9039273B2 (en) 2005-03-04 2015-05-26 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
FR2948024B1 (en) * 2009-07-17 2020-01-10 Centre National De La Recherche Scientifique - Cnrs - ULTRASOUND ACTIVABLE EMULSION AND MANUFACTURING METHOD THEREOF.
BR112012004719A2 (en) 2009-09-02 2016-04-05 Harvard College multiple emulsions created by blasting and other techniques
JP2013503742A (en) * 2009-09-02 2013-02-04 プレジデント アンド フェロウズ オブ ハーバード カレッジ Multiple emulsions produced using junctions
WO2011046443A1 (en) * 2009-10-15 2011-04-21 Vivid As Ultrasound triggered controlled release drug delivery
WO2011056390A2 (en) * 2009-11-03 2011-05-12 Manuel Marquez Method of making an artificial micro-gland that is anisotropic
US20110229545A1 (en) * 2010-03-17 2011-09-22 President And Fellows Of Harvard College Melt emulsification
EP2714254B1 (en) * 2011-05-23 2017-09-06 President and Fellows of Harvard College Control of emulsions, including multiple emulsions
CN103764265A (en) 2011-07-06 2014-04-30 哈佛学院院长等 Multiple emulsions and techniques for formulating multiple emulsions
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN114891871A (en) 2012-08-14 2022-08-12 10X基因组学有限公司 Microcapsule compositions and methods
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2900543C (en) 2013-02-08 2023-01-31 10X Genomics, Inc. Partitioning and processing of analytes and other species
CN103240043B (en) * 2013-05-09 2014-08-13 四川大学 Preparation method of monodisperse multicomponent multiple emulsion
CA2943624A1 (en) * 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US11065348B2 (en) 2014-06-19 2021-07-20 The Trustees Of The University Of Pennsylvania Apparatus and methods for making recombinant protein-stabilized monodisperse microbubbles
EP3161162A4 (en) 2014-06-26 2018-01-10 10X Genomics, Inc. Analysis of nucleic acid sequences
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
AU2015279548B2 (en) 2014-06-26 2020-02-27 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
KR20170073667A (en) 2014-10-29 2017-06-28 10엑스 제노믹스, 인크. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
CA2972113C (en) 2014-12-24 2023-03-14 National Research Council Of Canada Microparticles and apparatus for smart ink production
EP3237224B1 (en) 2014-12-24 2024-06-19 National Research Council of Canada Dynamic security device
US10221436B2 (en) 2015-01-12 2019-03-05 10X Genomics, Inc. Processes and systems for preparation of nucleic acid sequencing libraries and libraries prepared using same
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
CN107532202A (en) 2015-02-24 2018-01-02 10X 基因组学有限公司 Methods for Targeted Nucleic Acid Sequence Coverage
SG10202108763UA (en) 2015-12-04 2021-09-29 10X Genomics Inc Methods and compositions for nucleic acid analysis
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2018009766A1 (en) * 2016-07-08 2018-01-11 President And Fellows Of Harvard College Formation of colloids or gels within droplets
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN117512066A (en) 2017-01-30 2024-02-06 10X基因组学有限公司 Methods and systems for droplet-based single cell barcoding
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CN109526228B (en) 2017-05-26 2022-11-25 10X基因组学有限公司 Single cell analysis of transposase accessible chromatin
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WO2022044506A1 (en) * 2020-08-25 2022-03-03 富士フイルム株式会社 Microchannel device, droplet production method, bubble production method, microcapsule production method, multiple emulsion production method, method for producing droplets including bubbles, and microchannel device manufacturing method

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Publication number Priority date Publication date Assignee Title
CN102892704A (en) * 2010-03-30 2013-01-23 巴黎综合理工学院 Apparatus for droplet formation in microfluidic circuits
CN102892704B (en) * 2010-03-30 2016-03-02 巴黎综合理工学院 Apparatus for droplet formation in microfluidic circuits

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