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WO2009045403A3 - MENIN REGULATION OF β-ISLET CELL PROLIFERATION - Google Patents

MENIN REGULATION OF β-ISLET CELL PROLIFERATION Download PDF

Info

Publication number
WO2009045403A3
WO2009045403A3 PCT/US2008/011318 US2008011318W WO2009045403A3 WO 2009045403 A3 WO2009045403 A3 WO 2009045403A3 US 2008011318 W US2008011318 W US 2008011318W WO 2009045403 A3 WO2009045403 A3 WO 2009045403A3
Authority
WO
WIPO (PCT)
Prior art keywords
menin
diabetes
cell proliferation
islet cell
regulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/011318
Other languages
French (fr)
Other versions
WO2009045403A2 (en
Inventor
Seung Kim
Satyajit Karnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of WO2009045403A2 publication Critical patent/WO2009045403A2/en
Publication of WO2009045403A3 publication Critical patent/WO2009045403A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is directed to the regulation of β-islet cell proliferation by menin and/or menin-related factors. The present invention provides methods of diagnosing or monitoring a disease or condition by measuring the expression of menin and/or menin-related factors, their corresponding gene products and antibodies specific for the gene products. In certain aspects, the subject methods diagnose, monitor, detect, and/or prevent diabetes, pre-diabetes, or gestational diabetes. Also provided herein are methods for screening for agents which modulate β-islet cell proliferation and methods of treating a subject for diabetes, pre-diabetes, or gestational diabetes.
PCT/US2008/011318 2007-10-01 2008-09-30 MENIN REGULATION OF β-ISLET CELL PROLIFERATION Ceased WO2009045403A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96045707P 2007-10-01 2007-10-01
US60/960,457 2007-10-01

Publications (2)

Publication Number Publication Date
WO2009045403A2 WO2009045403A2 (en) 2009-04-09
WO2009045403A3 true WO2009045403A3 (en) 2009-08-06

Family

ID=40419482

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/011318 Ceased WO2009045403A2 (en) 2007-10-01 2008-09-30 MENIN REGULATION OF β-ISLET CELL PROLIFERATION

Country Status (1)

Country Link
WO (1) WO2009045403A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011085066A2 (en) * 2010-01-06 2011-07-14 Curna, Inc. Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
IN2014DN09410A (en) 2012-04-13 2015-07-17 Diabetomics Llc
WO2018160534A1 (en) 2017-02-28 2018-09-07 Joslin Diabetes Center Protection of beta cells from immune attack

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001130A1 (en) * 1999-06-25 2001-01-04 Proteome Sciences Plc METHODS AND COMPOSITIONS RELATING TO PANCREATIC ISLET AND β-CELL DYSFUNCTION
WO2005058142A2 (en) * 2003-12-16 2005-06-30 Emory University Diabetes diagnostic
WO2006035024A1 (en) * 2004-09-29 2006-04-06 Mellitus, S.L. Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease
US20070218519A1 (en) * 2005-10-11 2007-09-20 Tethys Bioscience, Inc. Diabetes-associated markers and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001130A1 (en) * 1999-06-25 2001-01-04 Proteome Sciences Plc METHODS AND COMPOSITIONS RELATING TO PANCREATIC ISLET AND β-CELL DYSFUNCTION
WO2005058142A2 (en) * 2003-12-16 2005-06-30 Emory University Diabetes diagnostic
WO2006035024A1 (en) * 2004-09-29 2006-04-06 Mellitus, S.L. Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease
US20070218519A1 (en) * 2005-10-11 2007-09-20 Tethys Bioscience, Inc. Diabetes-associated markers and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HEIT JEREMY J ET AL: "Intrinsic regulators of pancreatic beta-cell proliferation", ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, vol. 22, 2006, pages 311 - 338, XP002521558, ISSN: 1081-0706 *
KHARROUBI I ET AL: "BCL-6: a possible missing link for anti-inflammatory PPAR-[delta] signalling in pancreatic beta cells", DIABETOLOGIA ; CLINICAL AND EXPERIMENTAL DIABETES AND METABOLISM, SPRINGER, BERLIN, DE, vol. 49, no. 10, 5 August 2006 (2006-08-05), pages 2350 - 2358, XP019417929, ISSN: 1432-0428 *

Also Published As

Publication number Publication date
WO2009045403A2 (en) 2009-04-09

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