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WO2009040047A3 - Therapeutic uses of ghrelin and combinations with stresscopin - Google Patents

Therapeutic uses of ghrelin and combinations with stresscopin Download PDF

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Publication number
WO2009040047A3
WO2009040047A3 PCT/EP2008/007802 EP2008007802W WO2009040047A3 WO 2009040047 A3 WO2009040047 A3 WO 2009040047A3 EP 2008007802 W EP2008007802 W EP 2008007802W WO 2009040047 A3 WO2009040047 A3 WO 2009040047A3
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WO
WIPO (PCT)
Prior art keywords
gln
lys
pro
ser
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/007802
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French (fr)
Other versions
WO2009040047A2 (en
Inventor
Dorian Bevec
Fabio Cavalli
Vera Cavalli
Gerald Bacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mondobiotech Laboratories AG
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Mondobiotech Laboratories AG
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Publication of WO2009040047A2 publication Critical patent/WO2009040047A2/en
Publication of WO2009040047A3 publication Critical patent/WO2009040047A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Diabetes (AREA)
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Abstract

The present invention is directed to the use of the peptide compound Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
PCT/EP2008/007802 2007-09-11 2008-09-09 Therapeutic uses of ghrelin and combinations with stresscopin Ceased WO2009040047A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07017763 2007-09-11
EP07017763.9 2007-09-11

Publications (2)

Publication Number Publication Date
WO2009040047A2 WO2009040047A2 (en) 2009-04-02
WO2009040047A3 true WO2009040047A3 (en) 2009-05-14

Family

ID=40351560

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/EP2008/007937 Ceased WO2009046853A1 (en) 2007-09-11 2008-09-09 Use of intermedin 47 peptide as a therapeutic agent
PCT/EP2008/007649 Ceased WO2009043469A2 (en) 2007-09-11 2008-09-09 Use of pneumadin as a therapeutic agent
PCT/EP2008/007524 Ceased WO2009039979A1 (en) 2007-09-11 2008-09-09 Use of the peptide pro-gly-thr-cys-glu-ile-cys-ala-tyr-ala-ala-cys-thr-gly-cys as a therapeutic agent
PCT/EP2008/007890 Ceased WO2009033773A2 (en) 2007-09-11 2008-09-09 Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
PCT/EP2008/007495 Ceased WO2009033692A2 (en) 2007-09-11 2008-09-09 Use of the peptides fibrinopeptide a and pyx-i as a therapeutic agents
PCT/EP2008/007802 Ceased WO2009040047A2 (en) 2007-09-11 2008-09-09 Therapeutic uses of ghrelin and combinations with stresscopin

Family Applications Before (5)

Application Number Title Priority Date Filing Date
PCT/EP2008/007937 Ceased WO2009046853A1 (en) 2007-09-11 2008-09-09 Use of intermedin 47 peptide as a therapeutic agent
PCT/EP2008/007649 Ceased WO2009043469A2 (en) 2007-09-11 2008-09-09 Use of pneumadin as a therapeutic agent
PCT/EP2008/007524 Ceased WO2009039979A1 (en) 2007-09-11 2008-09-09 Use of the peptide pro-gly-thr-cys-glu-ile-cys-ala-tyr-ala-ala-cys-thr-gly-cys as a therapeutic agent
PCT/EP2008/007890 Ceased WO2009033773A2 (en) 2007-09-11 2008-09-09 Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
PCT/EP2008/007495 Ceased WO2009033692A2 (en) 2007-09-11 2008-09-09 Use of the peptides fibrinopeptide a and pyx-i as a therapeutic agents

Country Status (8)

Country Link
US (1) US20100216722A1 (en)
EP (1) EP2187937A1 (en)
JP (1) JP2010538993A (en)
KR (1) KR20100056507A (en)
AU (1) AU2008303941A1 (en)
CA (1) CA2698762A1 (en)
RU (1) RU2010114062A (en)
WO (6) WO2009046853A1 (en)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
WO2011066379A2 (en) * 2009-11-24 2011-06-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. METHOD OF REDUCING INTRATUMORAL pHe AND ACID-MEDIATED INVASION
CN104107419A (en) * 2014-05-29 2014-10-22 四川大学华西医院 Application of ghrelin in preventing or/and treating radioactive lung injury
US10265383B2 (en) 2014-09-09 2019-04-23 The Feinstein Institute For Medical Research Treatment of radiation injury using ghrelin
KR101716806B1 (en) * 2015-03-20 2017-03-17 서강대학교산학협력단 Compositions for Inhibition, Improvement or Alleviation of Itching
JP6694216B2 (en) * 2015-10-14 2020-05-13 学校法人 久留米大学 Prophylactic / therapeutic agent for Rett syndrome (RTT) containing ghrelin as an active ingredient
US20190160029A1 (en) * 2016-05-02 2019-05-30 The Regents Of The University Of Michigan Compositions and methods for the treatment of pulmonary arterial hypertension

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