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WO2008138868A3 - Diagnostic et/ou pronostic de cancer in vitro par analyse de l'expression de la protéine gtpase - Google Patents

Diagnostic et/ou pronostic de cancer in vitro par analyse de l'expression de la protéine gtpase Download PDF

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Publication number
WO2008138868A3
WO2008138868A3 PCT/EP2008/055714 EP2008055714W WO2008138868A3 WO 2008138868 A3 WO2008138868 A3 WO 2008138868A3 EP 2008055714 W EP2008055714 W EP 2008055714W WO 2008138868 A3 WO2008138868 A3 WO 2008138868A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
rho
prognosis
expression profile
analysis
Prior art date
Application number
PCT/EP2008/055714
Other languages
English (en)
Other versions
WO2008138868A2 (fr
Inventor
Del Pulgar Ma Teresa Gomez
De Molina Ana Ramirez
Sanjuan Juan Carlos Lacal
Original Assignee
Traslational Cancer Drugs Phar
Consejo Superior Investigacion
Del Pulgar Ma Teresa Gomez
De Molina Ana Ramirez
Sanjuan Juan Carlos Lacal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Traslational Cancer Drugs Phar, Consejo Superior Investigacion, Del Pulgar Ma Teresa Gomez, De Molina Ana Ramirez, Sanjuan Juan Carlos Lacal filed Critical Traslational Cancer Drugs Phar
Publication of WO2008138868A2 publication Critical patent/WO2008138868A2/fr
Publication of WO2008138868A3 publication Critical patent/WO2008138868A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé in vitro de diagnostic/pronostic du cancer, principalement du cancer du sein et/ou du cancer du poumon, qui fait appel à l'analyse dans un seul prélèvement du profil d'expression de la protéine Rnd2/Rho 7 ou, simultanément, du profil d'expression d'une protéine de la sous-famille de protéines Rnd composée des protéines suivantes: Rndl / Rho 6, Rnd2 / Rho 7 et Rnd3 / RhoE / Rho8. On peut ajouter au profil d'expression desdites protéines d'autres GTPases d'autres sous-familles, par exemple: Rho, Rac, Cdc42, RhoBTB et Miro. L'invention se rapporte en outre à un dispositif d'essai qui comprend des séquences d'acides nucléiques capables de s'hybrider avec des séquences appartenant aux gènes des différentes familles de GTPases dont on doit mesurer le profil d'expression. L'utilisation de ce dispositif d'essai permet non seulement de diagnostiquer le cancer, mais également d'établir le pronostic du développement de la maladie et de surveiller les traitements visant à la guérir.
PCT/EP2008/055714 2007-05-09 2008-05-08 Diagnostic et/ou pronostic de cancer in vitro par analyse de l'expression de la protéine gtpase WO2008138868A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200701252 2007-05-09
ES200701252 2007-05-09

Publications (2)

Publication Number Publication Date
WO2008138868A2 WO2008138868A2 (fr) 2008-11-20
WO2008138868A3 true WO2008138868A3 (fr) 2009-01-08

Family

ID=39638728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/055714 WO2008138868A2 (fr) 2007-05-09 2008-05-08 Diagnostic et/ou pronostic de cancer in vitro par analyse de l'expression de la protéine gtpase

Country Status (1)

Country Link
WO (1) WO2008138868A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2445627C1 (ru) * 2010-09-02 2012-03-20 Учреждение Российской Академии Наук Институт Биологии Гена Ран Способ диагностики немелкоклеточного рака легких и набор для его осуществления

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050142580A1 (en) * 2003-09-03 2005-06-30 Tay Sun K. Methods and probes for diagnosing a gynaecological condition
WO2005115394A2 (fr) * 2004-04-20 2005-12-08 New York University School Of Medicine Commutateur electrostatique prenyle et procedes d'utilisation
WO2006016110A1 (fr) * 2004-08-10 2006-02-16 University College Cardiff Consultants Limited Procedes et trousse pour le pronostic du cancer du sein
WO2006055833A2 (fr) * 2004-11-19 2006-05-26 Children's Hospital Medical Center Inhibiteurs de la gtpase et utilisation de ces derniers dans le controle de l'hyperactivite des plaquettes
WO2007005946A2 (fr) * 2005-07-05 2007-01-11 Cytoskeleton Inc. Detection de proteines rho
EP1757692A1 (fr) * 2004-04-21 2007-02-28 Daiichi Pharmaceutical Co., Ltd. GENE CODANT POUR UN FACTEUR D'ECHANGE DE NUCLOTIDE GUANINE LIANT RhoA

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050142580A1 (en) * 2003-09-03 2005-06-30 Tay Sun K. Methods and probes for diagnosing a gynaecological condition
WO2005115394A2 (fr) * 2004-04-20 2005-12-08 New York University School Of Medicine Commutateur electrostatique prenyle et procedes d'utilisation
EP1757692A1 (fr) * 2004-04-21 2007-02-28 Daiichi Pharmaceutical Co., Ltd. GENE CODANT POUR UN FACTEUR D'ECHANGE DE NUCLOTIDE GUANINE LIANT RhoA
WO2006016110A1 (fr) * 2004-08-10 2006-02-16 University College Cardiff Consultants Limited Procedes et trousse pour le pronostic du cancer du sein
WO2006055833A2 (fr) * 2004-11-19 2006-05-26 Children's Hospital Medical Center Inhibiteurs de la gtpase et utilisation de ces derniers dans le controle de l'hyperactivite des plaquettes
WO2007005946A2 (fr) * 2005-07-05 2007-01-11 Cytoskeleton Inc. Detection de proteines rho

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BEKTIC J ET AL: "Identification of genes involved in estrogenic action in the human prostate using microarray analysis", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 83, no. 1, 1 January 2004 (2004-01-01), pages 34 - 44, XP004479145, ISSN: 0888-7543 *
CUIYAN ZHANG ET AL: "Overexpression of RhoE in Non-small Cell Lung Cancer (NSCLC) is associated with smoking and correlates with DNA copy number changes.", CANCER BIOLOGY & THERAPY MAR 2007, vol. 6, no. 3, March 2007 (2007-03-01), pages 335 - 342, XP002501355, ISSN: 1538-4047 *
FRITZ G ET AL: "Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters", BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 87, 1 January 2002 (2002-01-01), pages 635 - 644, XP002319076, ISSN: 0007-0920 *
HUANG HERVÉ ET AL: "Gene expression profiling and subgroup identification of oligodendrogliomas.", ONCOGENE 5 AUG 2004, vol. 23, no. 35, 5 August 2004 (2004-08-05), pages 6012 - 6022, XP002490600, ISSN: 0950-9232 *
ONGUSAHA ET AL: "RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress", CURRENT BIOLOGY, CURRENT SCIENCE, GB, vol. 16, no. 24, 18 December 2006 (2006-12-18), pages 2466 - 2472, XP005730864, ISSN: 0960-9822 *
VAYSSIERE B ET AL: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 467, no. 1, 4 February 2000 (2000-02-04), pages 91 - 96, XP004260929, ISSN: 0014-5793 *
VEGA F M ET AL: "Rho GTPases in cancer cell biology", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 582, no. 14, 18 June 2008 (2008-06-18), pages 2093 - 2101, XP022699971, ISSN: 0014-5793, [retrieved on 20080505] *
VEGA FRANCISCO M ET AL: "SnapShot: Rho family GTPases.", CELL 29 JUN 2007, vol. 129, no. 7, 29 June 2007 (2007-06-29), pages 1430, XP002501197, ISSN: 0092-8674 *
VILLALONGA PRIAM ET AL: "RhoE inhibits cell cycle progression and Ras-induced transformation.", MOLECULAR AND CELLULAR BIOLOGY SEP 2004, vol. 24, no. 18, September 2004 (2004-09-01), pages 7829 - 7840, XP002501196, ISSN: 0270-7306 *
WANG L ET AL: "A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 278, no. 45, 7 November 2003 (2003-11-07), pages 44617 - 44625, XP002312008, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2008138868A2 (fr) 2008-11-20

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