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WO2008137102A3 - Methods of modulating amyloid beta and compounds useful therefor - Google Patents

Methods of modulating amyloid beta and compounds useful therefor Download PDF

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Publication number
WO2008137102A3
WO2008137102A3 PCT/US2008/005719 US2008005719W WO2008137102A3 WO 2008137102 A3 WO2008137102 A3 WO 2008137102A3 US 2008005719 W US2008005719 W US 2008005719W WO 2008137102 A3 WO2008137102 A3 WO 2008137102A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
levels
methods
modulating
compounds useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/005719
Other languages
French (fr)
Other versions
WO2008137102A2 (en
Inventor
Soan Cheng
Daniel D. Comer
Long Mao
David Pleynet
Chengzhi Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TorreyPines Therapeutics Inc
Original Assignee
TorreyPines Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TorreyPines Therapeutics Inc filed Critical TorreyPines Therapeutics Inc
Publication of WO2008137102A2 publication Critical patent/WO2008137102A2/en
Anticipated expiration legal-status Critical
Publication of WO2008137102A3 publication Critical patent/WO2008137102A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

In accordance with the present invention, novel compounds have been discovered that are useful for a variety of therapeutic applications, e.g., for modulating amyloid-beta levels. Accordingly, invention compounds find use in the treatment of a variety of diseases. Compositions and kits comprising invention compounds are also provided. In one aspect of the present invention, there are provided compounds which have activity in modulating levels of amyloid-beta (AjS). As a result, such compounds are applicable for treating diseases associated with aberrant levels of Aβ and/or any condition in which modulation of Aβ levels provides a therapeutic effect. Preferably, compounds herein are useful in the treatment of neurodegenerative disorders, such as AD.
PCT/US2008/005719 2007-05-04 2008-05-01 Methods of modulating amyloid beta and compounds useful therefor Ceased WO2008137102A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91624607P 2007-05-04 2007-05-04
US60/916,246 2007-05-04

Publications (2)

Publication Number Publication Date
WO2008137102A2 WO2008137102A2 (en) 2008-11-13
WO2008137102A3 true WO2008137102A3 (en) 2010-05-27

Family

ID=39944170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/005719 Ceased WO2008137102A2 (en) 2007-05-04 2008-05-01 Methods of modulating amyloid beta and compounds useful therefor

Country Status (1)

Country Link
WO (1) WO2008137102A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592471B2 (en) 2009-05-07 2013-11-26 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands

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TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
CA2651396A1 (en) * 2006-05-19 2007-11-29 Eisai R&D Management Co., Ltd. Urea type cinnamide derivative
PE20081791A1 (en) 2007-02-28 2009-02-07 Eisai Randd Man Co Ltd TWO CYCLIC DERIVATIVES OF OXOMORPHOLIN
WO2009020960A1 (en) * 2007-08-06 2009-02-12 The Regents Of The University Of California Preparation of novel 1,3-substituted ureas as inhibitors of soluble epoxide hydrolase
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
AR068121A1 (en) 2007-08-31 2009-11-04 Eisai R&D Man Co Ltd MULTICICLICAL COMPOUNDS TO TREAT NEURODEGENERATIVE DISEASES
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
PL2427436T3 (en) * 2009-05-07 2013-06-28 Gruenenthal Gmbh Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands
EP2455370A1 (en) 2009-07-17 2012-05-23 Shionogi&Co., Ltd. Pharmaceutical product containing lactam or benzene sulfonamide compound
WO2011016559A1 (en) * 2009-08-07 2011-02-10 武田薬品工業株式会社 Heterocyclic compound and use thereof
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
CA2817093A1 (en) * 2010-11-15 2012-05-24 Abbvie Inc. Nampt inhibitors
ES2602794T3 (en) 2011-03-31 2017-02-22 Pfizer Inc Novel bicyclic pyridinones
UA110688C2 (en) 2012-09-21 2016-01-25 Пфайзер Інк. Bicyclic pirydynony
US9468632B2 (en) 2012-11-28 2016-10-18 The Regents Of The University Of Michigan Methods and compositions for targeting cancer stem cells
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
TW201444798A (en) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
CN106061964B (en) * 2014-01-20 2019-10-25 豪夫迈·罗氏有限公司 N-phenyl-lactam derivatives capable of stimulating neurogenesis and their use in the treatment of neurological disorders
CN107406445B (en) 2015-02-03 2019-12-24 辉瑞公司 Novel cyclopropylbenzofurylpyridopyrazine diketones
CN106467538B (en) * 2015-08-14 2019-03-05 沈阳中化农药化工研发有限公司 A kind of substituted tetrahydro isoquinoline compound and purposes
CN107226777A (en) * 2016-08-03 2017-10-03 沈阳金久奇科技有限公司 Synthesis method of 1, 2-diphenoxyl ethane thermosensitive sensitizer
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CN114805054B (en) * 2022-05-31 2024-05-28 浙江精进药业有限公司 Synthesis method of gemfibrozil Ji Xiu derivative
GB202302032D0 (en) * 2023-02-13 2023-03-29 Pathios Therapeutics Ltd Compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070538A1 (en) * 2003-05-14 2005-03-31 Soan Cheng Compounds and uses thereof in modulating amyloid beta

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070538A1 (en) * 2003-05-14 2005-03-31 Soan Cheng Compounds and uses thereof in modulating amyloid beta

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592471B2 (en) 2009-05-07 2013-11-26 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
US8946204B2 (en) 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
US9120756B2 (en) 2009-05-07 2015-09-01 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
US9624209B2 (en) 2009-05-07 2017-04-18 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands

Also Published As

Publication number Publication date
WO2008137102A2 (en) 2008-11-13

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