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WO2008136324A1 - ヘテロ環およびホスホノアミノ基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤 - Google Patents

ヘテロ環およびホスホノアミノ基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤 Download PDF

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Publication number
WO2008136324A1
WO2008136324A1 PCT/JP2008/057851 JP2008057851W WO2008136324A1 WO 2008136324 A1 WO2008136324 A1 WO 2008136324A1 JP 2008057851 W JP2008057851 W JP 2008057851W WO 2008136324 A1 WO2008136324 A1 WO 2008136324A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
atom
phosphonoamino
hydrogen atom
alkoxylated
Prior art date
Application number
PCT/JP2008/057851
Other languages
English (en)
French (fr)
Inventor
Keigo Tanaka
Eiichi Yamamoto
Naoaki Watanabe
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to EP08740790A priority Critical patent/EP2141171A4/en
Priority to NZ578930A priority patent/NZ578930A/en
Priority to JP2009512940A priority patent/JPWO2008136324A1/ja
Priority to AU2008246754A priority patent/AU2008246754B2/en
Priority to CA002684503A priority patent/CA2684503A1/en
Priority to BRPI0808833-0A priority patent/BRPI0808833A2/pt
Priority to MX2009011532A priority patent/MX2009011532A/es
Publication of WO2008136324A1 publication Critical patent/WO2008136324A1/ja
Priority to IL201421A priority patent/IL201421A0/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、優れた抗真菌作用を有し、物性、特に、水への溶解性、および安全性の面でも優れた抗真菌剤を提供する。本発明によれば、下式（I）で表される化合物またはその塩； 　[式中、 Ｒ１が、水素原子、ハロゲン原子、アミノ基、Ｒ１１－ＮＨ－（Ｒ１１が、Ｃ１－６アルキル基、ヒドロキシＣ１－６アルキル基、Ｃ１－６アルコキシＣ１－６アルキル基、またはＣ１－６アルコキシカルボニルＣ１－６アルキル基を意味する。）、Ｒ１２－（ＣＯ）－ＮＨ－（Ｒ１２が、Ｃ１－６アルキル基またはＣ１－６アルコキシＣ１－６アルキル基）、Ｃ１－６アルキル基、ヒドロキシＣ１-６アルキル基、シアノＣ１-６アルキル基、Ｃ１－６アルコキシ基、またはＣ１－６アルコキシＣ１－６アルキル基、またはホスホノアミノ基を意味し；Ｒ２が、水素原子、Ｃ１-６アルキル基、アミノ基、ジＣ１-６アルキルアミノ基、またはホスホノアミノ基を意味し；ＸおよびＹの一方が、窒素原子を、他方が、窒素原子または酸素原子を意味し；環Ａが、ハロゲン原子もしくはＣ１-６アルキル基を１個もしくは２個有していてもよい、５もしくは６員のへテロアリール環またはベンゼン環を意味し；Ｚが、単結合、メチレン基、エチレン基、酸素原子、硫黄原子、－ＣＨ２Ｏ－、－ＯＣＨ２－、－ＮＨ－、－ＣＨ２ＮＨ－、－ＮＨＣＨ２－、－ＣＨ２Ｓ－、または－ＳＣＨ２－を意味し；Ｒ３が、水素原子、ハロゲン原子、または、置換基を１個もしくは２個有していてもよい、Ｃ１－６アルキル基、Ｃ３－８シクロアルキル基、Ｃ６－１０アリール基、５もしくは６員へテロアリール基、または５もしくは６員の非芳香族系へテロ環式基を意味し；Ｒ４が、水素原子またはハロゲン原子を意味する。 　ただし、Ｒ１およびＲ２のいずれか一方はホスホノアミノ基を意味する。」を開示する。
PCT/JP2008/057851 2007-04-27 2008-04-23 ヘテロ環およびホスホノアミノ基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤 WO2008136324A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP08740790A EP2141171A4 (en) 2007-04-27 2008-04-23 HETEROCYCLE-SUBSTITUTED PYRIDINE DERIVATIVE AND PHOSPHONOAMINO AND ANTIFUNGAL AGENT CONTAINING THE SAME
NZ578930A NZ578930A (en) 2007-04-27 2008-04-23 Pyridine derivatives substituted by heterocycle ring and phosphonoamino and antifungal agent containing the same
JP2009512940A JPWO2008136324A1 (ja) 2007-04-27 2008-04-23 ヘテロ環およびホスホノアミノ基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤
AU2008246754A AU2008246754B2 (en) 2007-04-27 2008-04-23 Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CA002684503A CA2684503A1 (en) 2007-04-27 2008-04-23 Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
BRPI0808833-0A BRPI0808833A2 (pt) 2007-04-27 2008-04-23 Derivados de piridina substituídos por anel heterocíclico e grupo fosfonoamino, e agente antifúngico contendo o mesmo
MX2009011532A MX2009011532A (es) 2007-04-27 2008-04-23 Derivados de piridina sustituidos por un anillo heterociclico y grupo fosfonoamino, y agente anti-fungal que contiene los mismos.
IL201421A IL201421A0 (en) 2007-04-27 2009-10-11 Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91461507P 2007-04-27 2007-04-27
JP2007118356 2007-04-27
US60/914,615 2007-04-27
JP2007-118356 2007-04-27

Publications (1)

Publication Number Publication Date
WO2008136324A1 true WO2008136324A1 (ja) 2008-11-13

Family

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Family Applications (1)

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PCT/JP2008/057851 WO2008136324A1 (ja) 2007-04-27 2008-04-23 ヘテロ環およびホスホノアミノ基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤

Country Status (16)

Country Link
US (1) US8507530B2 (ja)
EP (1) EP2141171A4 (ja)
JP (1) JPWO2008136324A1 (ja)
KR (1) KR20100015909A (ja)
CN (1) CN101668767A (ja)
AU (1) AU2008246754B2 (ja)
BR (1) BRPI0808833A2 (ja)
CA (1) CA2684503A1 (ja)
IL (1) IL201421A0 (ja)
MX (1) MX2009011532A (ja)
NZ (1) NZ578930A (ja)
RU (1) RU2009143926A (ja)
SA (1) SA08290258B1 (ja)
TW (1) TW200841879A (ja)
WO (1) WO2008136324A1 (ja)
ZA (1) ZA200905435B (ja)

Cited By (10)

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Publication number Priority date Publication date Assignee Title
WO2009084621A1 (ja) * 2007-12-27 2009-07-09 Eisai R & D Management Co., Ltd. ヘテロ環およびホスホノキシメチル基が置換したピリジン誘導体ならびにそれらを含有する抗真菌剤
WO2010032874A1 (ja) * 2008-09-19 2010-03-25 住友化学株式会社 農業用組成物
WO2011051198A2 (de) 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
US8507530B2 (en) 2007-04-27 2013-08-13 Eisai R&D Management Co., Ltd. Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
JP2014034523A (ja) * 2012-08-07 2014-02-24 Manac Inc モノまたはジハロゲノピリジルアミン類の製造方法
WO2017178549A1 (en) 2016-04-12 2017-10-19 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
WO2020179859A1 (ja) 2019-03-06 2020-09-10 第一三共株式会社 ピロロピラゾール誘導体
JP2021512946A (ja) * 2018-02-05 2021-05-20 ユニヴェルスィテ・ドゥ・ストラスブール 疼痛を治療するための化合物および組成物
JP7574450B2 (ja) 2020-12-15 2024-10-28 シーセン ファーマシューティカル カンパニー リミテッド アミノピリジン系化合物及びその使用

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JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
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PT3720438T (pt) 2017-12-07 2023-12-07 Amplyx Pharmaceuticals Inc Agentes antifúngicos derivados de piridina substituídos por heterociclo
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