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WO2008133102A1 - 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物 - Google Patents

新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物 Download PDF

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Publication number
WO2008133102A1
WO2008133102A1 PCT/JP2008/057322 JP2008057322W WO2008133102A1 WO 2008133102 A1 WO2008133102 A1 WO 2008133102A1 JP 2008057322 W JP2008057322 W JP 2008057322W WO 2008133102 A1 WO2008133102 A1 WO 2008133102A1
Authority
WO
WIPO (PCT)
Prior art keywords
base
dispersion
solid dispersion
composition containing
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/057322
Other languages
English (en)
French (fr)
Inventor
Shunji Uramatsu
Akane Kida
Hitoshi Shinike
Toshinobu Uemura
Yoshinobu Fukumori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Kasei KK
Daido Chemical Corp
Original Assignee
Nisshin Kasei KK
Daido Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Kasei KK, Daido Chemical Corp filed Critical Nisshin Kasei KK
Priority to US12/450,967 priority Critical patent/US9101617B2/en
Priority to CN200880012243.XA priority patent/CN101657216B/zh
Priority to EP08740408A priority patent/EP2140883B1/en
Priority to JP2009511805A priority patent/JP5328643B2/ja
Publication of WO2008133102A1 publication Critical patent/WO2008133102A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

　本発明は新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物に係るものである。固体分散体用基剤としてポリビニルアルコール系共重合体を難溶性成分と混合及び加熱して固体分散体を製造することによって、難溶性成分の溶解性に非常に優れた固体分散体が得られる。
PCT/JP2008/057322 2007-04-20 2008-04-15 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物 Ceased WO2008133102A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/450,967 US9101617B2 (en) 2007-04-20 2008-04-15 Base for dry solid dispersion, solid dispersion containing the base, and composition containing the dispersion
CN200880012243.XA CN101657216B (zh) 2007-04-20 2008-04-15 干式固体分散体用基剂、含有该基剂的固体分散体及含有该分散体的组合物
EP08740408A EP2140883B1 (en) 2007-04-20 2008-04-15 Novel base for dry solid dispersion, solid dispersion containing the base, and composition containing the dispersion
JP2009511805A JP5328643B2 (ja) 2007-04-20 2008-04-15 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-111937 2007-04-20
JP2007111937 2007-04-20

Publications (1)

Publication Number Publication Date
WO2008133102A1 true WO2008133102A1 (ja) 2008-11-06

Family

ID=39925560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057322 Ceased WO2008133102A1 (ja) 2007-04-20 2008-04-15 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物

Country Status (5)

Country Link
US (1) US9101617B2 (ja)
EP (1) EP2140883B1 (ja)
JP (1) JP5328643B2 (ja)
CN (1) CN101657216B (ja)
WO (1) WO2008133102A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012056950A (ja) * 2010-08-12 2012-03-22 Nisshin Kasei Kk 可溶化剤
US20120157580A1 (en) * 2009-08-31 2012-06-21 Hiroyuki Yoshino Coating composition
JP2014177415A (ja) * 2013-03-13 2014-09-25 Daido Kasei Kogyo Kk ナノ粒子化製剤及びその製造方法
US20140356429A1 (en) * 2010-07-20 2014-12-04 Japan Tobacco Inc. Tablet containing ferric citrate
WO2016027720A1 (ja) * 2014-08-20 2016-02-25 日本合成化学工業株式会社 農薬分散剤およびこれを用いた農薬分散液
EP3238711A1 (en) 2016-04-26 2017-11-01 The Nippon Synthetic Chemical Industry Co., Ltd. Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
JP2017197723A (ja) * 2016-04-26 2017-11-02 日本合成化学工業株式会社 固体分散体用基剤、それを用いた固体分散体の製造方法及び固体分散体
JP2018502160A (ja) * 2015-01-20 2018-01-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 担体ポリマーとしてのポリビニルアルコールを用いた化合物の固体分散体
WO2020027035A1 (ja) 2018-07-30 2020-02-06 三菱ケミカル株式会社 熱溶融型積層造形用材料
JP2021504487A (ja) * 2017-11-30 2021-02-15 ベーイーテー ファルマ ゲーエムベーハー 固体分散体を調製するための方法および装置

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102204868B (zh) * 2011-05-18 2014-01-22 北京化工大学 采用多元辅料制备吲哚美辛速释制剂的热熔挤出工艺
CN114886853A (zh) * 2011-10-14 2022-08-12 阵列生物制药公司 ErbB2(HER2)抑制剂的固态分散体
CN102406940B (zh) * 2011-11-01 2013-07-03 温州大学 一种纳米级片状羧甲基淀粉钠在固体分散体中的应用
PT3454906T (pt) 2016-05-13 2025-10-22 Merck Patent Gmbh Tamanho de partícula e distribuição de polímero para aplicação de extrusão por fusão
CN117120036A (zh) * 2021-04-01 2023-11-24 默克专利股份公司 低溶性药物的连续热熔融制粒方法
CN115624551A (zh) * 2022-10-18 2023-01-20 江苏集萃新型药物制剂技术研究所有限公司 甲氧苄啶固体分散体及其复合制剂和制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05262642A (ja) 1992-01-24 1993-10-12 Fujisawa Pharmaceut Co Ltd 難溶性薬物の固体分散体の製造方法
WO2000064894A1 (en) 1999-04-23 2000-11-02 Takeda Chemical Industries, Ltd. 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
WO2001077107A1 (en) 2000-04-07 2001-10-18 Takeda Chemical Industries, Ltd. Oxazole derivatives and their uses as tyrosine kinase inhibitors
WO2002017848A1 (fr) 2000-08-29 2002-03-07 Nisshin Kasei Co., Ltd. Capsule en dur
JP2004534811A (ja) * 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク ポリマーと薬剤の集合体を含む医薬組成物
JP2006500349A (ja) * 2002-08-12 2006-01-05 ファイザー・プロダクツ・インク 半順序薬剤およびポリマーの医薬組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4990335A (en) * 1987-03-25 1991-02-05 E. I. Du Pont De Nemours And Company Use of vinyl alcohol homopolymer and copolymers for tableting active materials
US8277844B2 (en) * 2003-08-20 2012-10-02 Shionogi & Co., Ltd. Coating composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05262642A (ja) 1992-01-24 1993-10-12 Fujisawa Pharmaceut Co Ltd 難溶性薬物の固体分散体の製造方法
WO2000064894A1 (en) 1999-04-23 2000-11-02 Takeda Chemical Industries, Ltd. 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
WO2001077107A1 (en) 2000-04-07 2001-10-18 Takeda Chemical Industries, Ltd. Oxazole derivatives and their uses as tyrosine kinase inhibitors
WO2002017848A1 (fr) 2000-08-29 2002-03-07 Nisshin Kasei Co., Ltd. Capsule en dur
JP2004534811A (ja) * 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク ポリマーと薬剤の集合体を含む医薬組成物
JP2006500349A (ja) * 2002-08-12 2006-01-05 ファイザー・プロダクツ・インク 半順序薬剤およびポリマーの医薬組成物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL., vol. 38, 1990, pages 2792 - 2796
J.ANTIBIOTICS, vol. 38, 1985, pages 877 - 885
JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 60, no. 2, 2000, pages 148 - 159
See also references of EP2140883A4 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120157580A1 (en) * 2009-08-31 2012-06-21 Hiroyuki Yoshino Coating composition
US20140356429A1 (en) * 2010-07-20 2014-12-04 Japan Tobacco Inc. Tablet containing ferric citrate
JP2012056950A (ja) * 2010-08-12 2012-03-22 Nisshin Kasei Kk 可溶化剤
JP2014177415A (ja) * 2013-03-13 2014-09-25 Daido Kasei Kogyo Kk ナノ粒子化製剤及びその製造方法
JP2020090549A (ja) * 2014-08-20 2020-06-11 三菱ケミカル株式会社 農薬分散液
WO2016027720A1 (ja) * 2014-08-20 2016-02-25 日本合成化学工業株式会社 農薬分散剤およびこれを用いた農薬分散液
JPWO2016027720A1 (ja) * 2014-08-20 2017-06-01 日本合成化学工業株式会社 農薬分散剤およびこれを用いた農薬分散液
JP7069533B2 (ja) 2014-08-20 2022-05-18 三菱ケミカル株式会社 農薬分散液
JP2018502160A (ja) * 2015-01-20 2018-01-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 担体ポリマーとしてのポリビニルアルコールを用いた化合物の固体分散体
EP3238711A1 (en) 2016-04-26 2017-11-01 The Nippon Synthetic Chemical Industry Co., Ltd. Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
JP2017197723A (ja) * 2016-04-26 2017-11-02 日本合成化学工業株式会社 固体分散体用基剤、それを用いた固体分散体の製造方法及び固体分散体
JP2021504487A (ja) * 2017-11-30 2021-02-15 ベーイーテー ファルマ ゲーエムベーハー 固体分散体を調製するための方法および装置
JP7250029B2 (ja) 2017-11-30 2023-03-31 ベーイーテー ファルマ ゲーエムベーハー 固体分散体を調製するための方法および装置
WO2020027035A1 (ja) 2018-07-30 2020-02-06 三菱ケミカル株式会社 熱溶融型積層造形用材料
US12043730B2 (en) 2018-07-30 2024-07-23 Mitsubishi Chemical Corporation Fused deposition modeling type additive manufacturing material

Also Published As

Publication number Publication date
US20100120924A1 (en) 2010-05-13
CN101657216B (zh) 2012-11-21
EP2140883A1 (en) 2010-01-06
EP2140883B1 (en) 2012-10-31
JP5328643B2 (ja) 2013-10-30
JPWO2008133102A1 (ja) 2010-07-22
US9101617B2 (en) 2015-08-11
CN101657216A (zh) 2010-02-24
EP2140883A4 (en) 2010-09-08

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