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WO2008132176A3 - Method for evaluating the response of an individual to tnf blocking therapy - Google Patents

Method for evaluating the response of an individual to tnf blocking therapy Download PDF

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Publication number
WO2008132176A3
WO2008132176A3 PCT/EP2008/055096 EP2008055096W WO2008132176A3 WO 2008132176 A3 WO2008132176 A3 WO 2008132176A3 EP 2008055096 W EP2008055096 W EP 2008055096W WO 2008132176 A3 WO2008132176 A3 WO 2008132176A3
Authority
WO
WIPO (PCT)
Prior art keywords
response
genes
tnf blocking
evaluating
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/055096
Other languages
French (fr)
Other versions
WO2008132176A2 (en
Inventor
Bernard Lauwerys
Valerie Badot
Frederic Houssiau
Den Eynde Benoit Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Catholique de Louvain UCL
Cliniques Universitaires Saint Luc
Original Assignee
Universite Catholique de Louvain UCL
Cliniques Universitaires Saint Luc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Catholique de Louvain UCL, Cliniques Universitaires Saint Luc filed Critical Universite Catholique de Louvain UCL
Publication of WO2008132176A2 publication Critical patent/WO2008132176A2/en
Publication of WO2008132176A3 publication Critical patent/WO2008132176A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention is directed to methods to predict the responsiveness of a patient to a TNF blocking drug comprising the steps of: a) assessing in a synovial sample from said patient at least two genes or a fragment thereofs or proteins encoded by said at least two genes, wherein said genes or fragment thereof is as defined in claim 1, and b) predicting the response to the treatment with the TNF blocking agent in said patient by evaluating the results of step (a). The invention is also directed to kits for predicting the response to a treatment with a TNF blocking agent comprising a low density microarray comprising probes suitable for hybridizing with at least two genes or fragments thereof as defined in the claims.
PCT/EP2008/055096 2007-04-27 2008-04-25 Method for evaluating the response of an individual to tnf blocking therapy Ceased WO2008132176A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107087.4 2007-04-27
EP07107087 2007-04-27

Publications (2)

Publication Number Publication Date
WO2008132176A2 WO2008132176A2 (en) 2008-11-06
WO2008132176A3 true WO2008132176A3 (en) 2009-04-09

Family

ID=38442071

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/055096 Ceased WO2008132176A2 (en) 2007-04-27 2008-04-25 Method for evaluating the response of an individual to tnf blocking therapy

Country Status (1)

Country Link
WO (1) WO2008132176A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982302B2 (en) 2011-02-28 2018-05-29 Genentech, Inc. Biological markers and methods for predicting response to B-cell antagonists

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100037590A (en) * 2007-06-08 2010-04-09 바이오겐 아이덱 엠에이 인코포레이티드 Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
ES2335381B1 (en) * 2008-09-24 2011-02-28 Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron IN VITRO METHOD AND KIT FOR THE FORECAST OR PREDICTION OF THE RESPONSE PART OF PATIENTS WITH REUMATOID ARTHRITIS TO THE TREATMENT WITH BLOCKING AGENTS OF THE TNFALFA FACTOR.
RU2539112C2 (en) 2009-09-03 2015-01-10 Дженентек, Инк. Methods of treating, diagnosing and monitoring of rheumatoid arthritis
WO2011085811A1 (en) * 2010-01-14 2011-07-21 Universite Catholique De Louvain Method for evaluating the response of rheumatoid arthritis patients to therapy and for diagnosing disease severity
BR112012019640A2 (en) 2010-02-05 2017-06-20 Translational Genomics Res Inst Methods and Kits Used in Classifying Adrenocortical Carcinoma
RS61082B1 (en) 2010-02-26 2020-12-31 Novo Nordisk As Stable antibody containing compositions
US20130095099A1 (en) * 2010-03-24 2013-04-18 Tc Land Expression Genes and genes combinations predictive of early response or non response of subjects suffering from inflammatory disease to cytokine targeting drugs (cytd)
RU2012153786A (en) 2010-05-28 2014-07-10 Ново Нордиск А/С STABLE MULTI-DOSE COMPOSITIONS CONTAINING ANTIBODY AND CONSERVANT
US9670547B2 (en) 2010-09-15 2017-06-06 Almac Diagnostics Limited Molecular diagnostic test for cancer
GB201018147D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Method of treatment
WO2012061620A1 (en) * 2010-11-04 2012-05-10 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
EP2668287B1 (en) * 2011-01-25 2017-09-06 TC LAND Expression Genes and genes combinations based on gene mknk1 predictive of early response or non response of subjects suffering from rheumatoid arthritis to tnf-alpha blocking monoclonal antibody
CA2854665A1 (en) * 2011-11-10 2013-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene expression signatures of neoplasm responsiveness to therapy
EP2818546B1 (en) * 2011-11-17 2017-06-28 DNA Chip Research Inc. Method for determining rheumatoid arthritis activity indicator, and biomarker used therein
CA2864133A1 (en) 2012-02-10 2013-08-15 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2013135789A1 (en) * 2012-03-15 2013-09-19 Universiteit Hasselt Means and methods for the determination of the joint destruction progression rate in rheumatoid arthritis patients
HU230680B1 (en) * 2012-10-19 2017-08-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Diagnostic method
EP2813850A1 (en) * 2013-06-10 2014-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting rheumatoid arthritis treatment response
EP3194611A1 (en) * 2014-08-01 2017-07-26 Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca Method to predict the lack of response to anti-tnf alpha therapies
GB201521357D0 (en) * 2015-12-03 2016-01-20 Univ Liverpool Methods for predicting response to anti-TNF therapy
US10022397B2 (en) * 2016-06-20 2018-07-17 Nobilis Therapeutics, Inc. Treatment of rheumatoid arthritis using noble gas mixtures
WO2023004371A1 (en) * 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Methods of differentiating neural cells and predicting engraftment thereof and related compositions

Citations (3)

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US20030154032A1 (en) * 2000-12-15 2003-08-14 Pittman Debra D. Methods and compositions for diagnosing and treating rheumatoid arthritis
WO2006122187A2 (en) * 2005-05-10 2006-11-16 Biogen Idec Ma Inc. Treating and evaluating inflammatory disorders
WO2007038501A2 (en) * 2005-09-27 2007-04-05 The Feinstein Institute For Medical Research Rheumatoid arthritis markers

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20030154032A1 (en) * 2000-12-15 2003-08-14 Pittman Debra D. Methods and compositions for diagnosing and treating rheumatoid arthritis
WO2006122187A2 (en) * 2005-05-10 2006-11-16 Biogen Idec Ma Inc. Treating and evaluating inflammatory disorders
WO2007038501A2 (en) * 2005-09-27 2007-04-05 The Feinstein Institute For Medical Research Rheumatoid arthritis markers

Non-Patent Citations (7)

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Title
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HAEUPL T ET AL: "GENE EXPRESSION PROFILING OF RHEUMATOID ARTHRITIS SYNOVIAL CELLS TREATED WITH ANTIRHEUMATIC DRUGS", JOURNAL OF BIOMOLECULAR SCREENING, LARCHMONT, NY, US, vol. 12, no. 3, 1 April 2007 (2007-04-01), pages 328 - 340, XP009083067, ISSN: 1087-0571 *
LEQUERRÉ THIERRY ET AL: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis", ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 4, 3 July 2006 (2006-07-03), pages R105, XP021020585, ISSN: 1478-6354 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982302B2 (en) 2011-02-28 2018-05-29 Genentech, Inc. Biological markers and methods for predicting response to B-cell antagonists

Also Published As

Publication number Publication date
WO2008132176A2 (en) 2008-11-06

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