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WO2008129624A1 - Pyrazolopyridine-4-yl-pyrazolone derivative, addition salt thereof and phosphodiesterase inhibitor containing the same as active ingredient - Google Patents

Pyrazolopyridine-4-yl-pyrazolone derivative, addition salt thereof and phosphodiesterase inhibitor containing the same as active ingredient Download PDF

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Publication number
WO2008129624A1
WO2008129624A1 PCT/JP2007/057905 JP2007057905W WO2008129624A1 WO 2008129624 A1 WO2008129624 A1 WO 2008129624A1 JP 2007057905 W JP2007057905 W JP 2007057905W WO 2008129624 A1 WO2008129624 A1 WO 2008129624A1
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WO
WIPO (PCT)
Prior art keywords
pyrazolopyridine
active ingredient
same
addition salt
pyrazolone derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/057905
Other languages
French (fr)
Japanese (ja)
Inventor
Yasushi Kohno
Naoki Ando
Koji Ochiai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to PCT/JP2007/057905 priority Critical patent/WO2008129624A1/en
Publication of WO2008129624A1 publication Critical patent/WO2008129624A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A novel pyrazolopyridine-4-yl-pyrazolone derivative represented by the following general formula (1): (1) (specific example: 6-(2-ethyl-7-methoxy-pyrazolo[1,5-a]pyridine-4-yl)-4,4-dimethyl-2,4-dihydro-3-pyrazolone) is useful as a pharmaceutical preparation having a phosphodiesterase inhibitory effect.
PCT/JP2007/057905 2007-04-10 2007-04-10 Pyrazolopyridine-4-yl-pyrazolone derivative, addition salt thereof and phosphodiesterase inhibitor containing the same as active ingredient Ceased WO2008129624A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/057905 WO2008129624A1 (en) 2007-04-10 2007-04-10 Pyrazolopyridine-4-yl-pyrazolone derivative, addition salt thereof and phosphodiesterase inhibitor containing the same as active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/057905 WO2008129624A1 (en) 2007-04-10 2007-04-10 Pyrazolopyridine-4-yl-pyrazolone derivative, addition salt thereof and phosphodiesterase inhibitor containing the same as active ingredient

Publications (1)

Publication Number Publication Date
WO2008129624A1 true WO2008129624A1 (en) 2008-10-30

Family

ID=39875172

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/057905 Ceased WO2008129624A1 (en) 2007-04-10 2007-04-10 Pyrazolopyridine-4-yl-pyrazolone derivative, addition salt thereof and phosphodiesterase inhibitor containing the same as active ingredient

Country Status (1)

Country Link
WO (1) WO2008129624A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014448A1 (en) * 1996-10-04 1998-04-09 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof
JP2006117647A (en) * 2004-09-22 2006-05-11 Kyorin Pharmaceut Co Ltd Halogenopyrazolopyridine pyridazinone derivatives and their addition salts and PDE inhibitors containing the same as active ingredients
JP2006169138A (en) * 2004-12-14 2006-06-29 Kyorin Pharmaceut Co Ltd Pyrazolopyridine pyrazolone derivatives and their addition salts and PDE inhibitors
WO2006095666A1 (en) * 2005-03-07 2006-09-14 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine-4-yl pyridazinone derivative and addition salt thereof, and pde inhibitor comprising the derivative or salt as active ingredient
JP2007091597A (en) * 2005-09-27 2007-04-12 Kyorin Pharmaceut Co Ltd Pyrazolopyridin-4-ylpyrazolone derivatives and their addition salts and phosphodiesterase inhibitors containing the same as active ingredients

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014448A1 (en) * 1996-10-04 1998-04-09 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof
JP2006117647A (en) * 2004-09-22 2006-05-11 Kyorin Pharmaceut Co Ltd Halogenopyrazolopyridine pyridazinone derivatives and their addition salts and PDE inhibitors containing the same as active ingredients
JP2006169138A (en) * 2004-12-14 2006-06-29 Kyorin Pharmaceut Co Ltd Pyrazolopyridine pyrazolone derivatives and their addition salts and PDE inhibitors
WO2006095666A1 (en) * 2005-03-07 2006-09-14 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine-4-yl pyridazinone derivative and addition salt thereof, and pde inhibitor comprising the derivative or salt as active ingredient
JP2007091597A (en) * 2005-09-27 2007-04-12 Kyorin Pharmaceut Co Ltd Pyrazolopyridin-4-ylpyrazolone derivatives and their addition salts and phosphodiesterase inhibitors containing the same as active ingredients

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