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WO2008126886A1 - Dérivé d'indole ou d'indoline - Google Patents

Dérivé d'indole ou d'indoline Download PDF

Info

Publication number
WO2008126886A1
WO2008126886A1 PCT/JP2008/057056 JP2008057056W WO2008126886A1 WO 2008126886 A1 WO2008126886 A1 WO 2008126886A1 JP 2008057056 W JP2008057056 W JP 2008057056W WO 2008126886 A1 WO2008126886 A1 WO 2008126886A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
disorder
double bond
indole
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/057056
Other languages
English (en)
Japanese (ja)
Inventor
Toshio Nakamura
Dai Nozawa
Makoto Tatsuzuki
Hiroshi Ohta
Tomoko Tamita
Seiji Masuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of WO2008126886A1 publication Critical patent/WO2008126886A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés d'indole ou d'indoline muni d'un antagonisme du récepteur d'histamine H3 et représentés par la formule : (1) (dans lequel la double liaison contenant une ligne ondoyante est une simple liaison ou une double liaison ; Q est l'un quelconque des groupes des formules structurelles : (A) (B) R est un groupe alkyle en C1-C6, -C(O)R4, etc. ; R1 est un groupe alkyle en C1-C6, etc. ; et chacun de R2 et R3 est indépendamment un groupe alkyle en C1-C6, cycloalkyle en C3-C8, etc.), ou des sels pharmaceutiquement acceptables de ceux-ci, et des préparations pharmaceutiques contenant l'un quelconque de ceux-ci en tant qu'ingrédient actif. Ils sont utiles dans la prévention ou le traitement de maladies telles que le déficit cognitif, la maladie d'Alzheimer, les troubles d'hyperactivité à déficit d'attention, la schizophrénie, les troubles de l'alimentation, l'obésité, le diabète sucré, l'hyperlipémie, les troubles du sommeil, la narcolepsie, le syndrome des apnées du sommeil, les troubles du rythme circadien, la dépression, la rhinite allergique, etc.
PCT/JP2008/057056 2007-04-12 2008-04-10 Dérivé d'indole ou d'indoline Ceased WO2008126886A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007104536 2007-04-12
JP2007-104536 2007-04-12
JP2007-281814 2007-10-30
JP2007281814 2007-10-30

Publications (1)

Publication Number Publication Date
WO2008126886A1 true WO2008126886A1 (fr) 2008-10-23

Family

ID=39863982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057056 Ceased WO2008126886A1 (fr) 2007-04-12 2008-04-10 Dérivé d'indole ou d'indoline

Country Status (1)

Country Link
WO (1) WO2008126886A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008302570B2 (en) * 2007-09-20 2012-05-31 Irm Llc Compounds and compositions as modulators of GPR119 activity
WO2017195703A1 (fr) * 2016-05-09 2017-11-16 日本曹達株式会社 Composé amine cyclique et agent de lutte contre les nuisibles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043956A1 (fr) * 1997-03-31 1998-10-08 Eisai Co., Ltd. Derives amines cycliques 1,4-substitues
JPH10512893A (ja) * 1995-01-31 1998-12-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗精神病性の４−（１ｈ−インドリル−１−イル）−１−置換ピペリジン誘導体
JP2006503056A (ja) * 2002-09-18 2006-01-26 イーライ・リリー・アンド・カンパニー ヒスタミンｈ３受容体アンタゴニスト、その製造および治療用使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10512893A (ja) * 1995-01-31 1998-12-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗精神病性の４−（１ｈ−インドリル−１−イル）−１−置換ピペリジン誘導体
WO1998043956A1 (fr) * 1997-03-31 1998-10-08 Eisai Co., Ltd. Derives amines cycliques 1,4-substitues
JP2006503056A (ja) * 2002-09-18 2006-01-26 イーライ・リリー・アンド・カンパニー ヒスタミンｈ３受容体アンタゴニスト、その製造および治療用使用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008302570B2 (en) * 2007-09-20 2012-05-31 Irm Llc Compounds and compositions as modulators of GPR119 activity
US8258156B2 (en) 2007-09-20 2012-09-04 Irm Llc Compounds and compositions as modulators of GPR119 activity
WO2017195703A1 (fr) * 2016-05-09 2017-11-16 日本曹達株式会社 Composé amine cyclique et agent de lutte contre les nuisibles
JPWO2017195703A1 (ja) * 2016-05-09 2019-02-14 日本曹達株式会社 環状アミン化合物および有害生物防除剤
US11178872B2 (en) 2016-05-09 2021-11-23 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent

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