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WO2008126846A1 - バンコマイシン耐性グラム陽性細菌用抗菌剤 - Google Patents

バンコマイシン耐性グラム陽性細菌用抗菌剤 Download PDF

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Publication number
WO2008126846A1
WO2008126846A1 PCT/JP2008/056966 JP2008056966W WO2008126846A1 WO 2008126846 A1 WO2008126846 A1 WO 2008126846A1 JP 2008056966 W JP2008056966 W JP 2008056966W WO 2008126846 A1 WO2008126846 A1 WO 2008126846A1
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WIPO (PCT)
Prior art keywords
vancomycin
antibacterial agent
positive bacterium
resistant gram
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056966
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English (en)
French (fr)
Inventor
Shoichi Shirotake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yokohama National University NUC
Yokohama City University
Original Assignee
Yokohama National University NUC
Yokohama City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yokohama National University NUC, Yokohama City University filed Critical Yokohama National University NUC
Priority to JP2009509349A priority Critical patent/JP4696256B2/ja
Publication of WO2008126846A1 publication Critical patent/WO2008126846A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

バンコマイシン耐性菌感染症の治療等に有用な、バンコマイシン耐性菌を効果的に抗菌できる抗菌剤が開示されている。抗菌剤は、抗生物質を抱合するシアノアクリレートポリマー粒子を有効成分として含有するバンコマイシン耐性グラム陽性細菌用抗菌剤であって、前記抗生物質は、単独では抗菌すべき前記バンコマイシン耐性グラム陽性細菌に抗菌活性を示さないが、シアノアクリレートポリマー粒子に抱合された状態では抗菌活性を示すものである。
PCT/JP2008/056966 2007-04-09 2008-04-09 バンコマイシン耐性グラム陽性細菌用抗菌剤 Ceased WO2008126846A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009509349A JP4696256B2 (ja) 2007-04-09 2008-04-09 バンコマイシン耐性グラム陽性細菌用抗菌剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-101610 2007-04-09
JP2007101610 2007-04-09

Publications (1)

Publication Number Publication Date
WO2008126846A1 true WO2008126846A1 (ja) 2008-10-23

Family

ID=39863943

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056966 Ceased WO2008126846A1 (ja) 2007-04-09 2008-04-09 バンコマイシン耐性グラム陽性細菌用抗菌剤

Country Status (2)

Country Link
JP (1) JP4696256B2 (ja)
WO (1) WO2008126846A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084494A1 (ja) * 2007-12-27 2009-07-09 Public University Corporation Yokohama City University グラム陽性細菌用抗菌剤
WO2010101178A1 (ja) * 2009-03-03 2010-09-10 公立大学法人横浜市立大学 アミノ酸抱合シアノアクリレートポリマー粒子
WO2012133648A1 (ja) 2011-03-31 2012-10-04 Shirotake Shoichi 高次構造体が示す抗細胞効果の新規調整技法
WO2013108871A1 (ja) 2012-01-19 2013-07-25 Shirotake Shoichi 植物病原細菌用抗菌剤
WO2016039412A1 (ja) * 2014-09-11 2016-03-17 チカミミルテック株式会社 抗菌剤および抗菌剤の製造方法
JP2016056481A (ja) * 2014-09-11 2016-04-21 チカミミルテック株式会社 抗菌性シートおよび抗菌性シートの製造方法
JP2017081852A (ja) * 2015-10-28 2017-05-18 チカミミルテック株式会社 抗菌剤および抗菌剤の製造方法
CN107988095A (zh) * 2017-11-27 2018-05-04 华中农业大学 一种高效降解四环素类抗生素的微生物菌剂及应用
WO2018193847A1 (ja) * 2017-04-18 2018-10-25 チカミミルテック株式会社 藻類増殖抑制剤および藻類の増殖を抑制する方法
US10351644B2 (en) 2014-02-27 2019-07-16 Shoichi Shirotake Antiviral drug
CN114010797A (zh) * 2021-11-26 2022-02-08 上海交通大学 一种细菌靶向纳米抗菌剂及其制备方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DOUGLAS S.J. ET AL.: "Particle Size and Size Distribution of Poly(butyl2-cyanoacrylate) Nanoparticles", J. COLLOID INTERFACE SCI., vol. 103, no. 1, January 1985 (1985-01-01), pages 154 - 163 *
HODOKI N. ET AL.: "Nanotechnology o Mochiita Yakuzaigakuteki Kiban Kenkyu XV -Nano Setsugo Kaimen ga Motarasu Vancomycin Taisei Kiko no Choetsu-", DAI 56 KAI HIGASHINIHON BRANCH OF JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES AND DAI 54 KAI HIGASHINIHON BRANCH OF JAPAN SOCIETY OF CHEMOTHERAPY, 10 September 2007 (2007-09-10), pages 136 *
HODOKI N. ET AL.: "Nanotechnology of Mochiita Yakuzaigakuteki Kiban Kenkyu XV -Nano Setsugo Kaimen ga Motarasu Vancomycin Taisei Kiko no Choetsu-", JAPANESE JOURNAL OF CHEMOTHERAPY, vol. 56, no. 2, 10 March 2008 (2008-03-10), pages 248 *
NAKAMURA J. ET AL.: "Nanotechnology o Mochiita Yakuzaigakuteki Kiban Kenkyu -IX. Kokin Kassei no Fine Tuning to Taisei Chiryo eno Senryaku-", THE PHARMACEUTICAL SOCIETY OF JAPAN DAI 127 NENKAI YOSHISHU, no. 3, 5 March 2007 (2007-03-05), pages 132 *
SHIROTAKE S. ET AL.: "Preparation of Cyanoacrylate Nanoparticles Using Monosaccharides or Disaccharides", CHEM. PHARM. BULL., vol. 56, no. 1, January 2008 (2008-01-01), pages 137 - 138 *
TONEGAWA A. ET AL.: "Nanotechnology o Mochiita Yakuzaigakuteki Kiban Kenkyu -VI. Kokin Kassei no Fine Tuning-", DAI 55 KAI HIGASHINIHON BRANCH OF JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES AND DAI 53 KAI HIGASHINIHON BRANCH OF JAPAN SOCIETY OF CHEMOTHERAPY, 2006, pages 121 *
TONEGAWA J. ET AL.: "Nanotechnology o Mochiita Takuzaigakuteki Kiban Kenkyu -VIII. Kokinyaku Hogo Nano Cupsule no Gosei to Kokin Kassei no Tansaku-", THE PHARMACEUTCIAL SOCIETY OF JAPAN DAI 127 NENKAI YOSHISHU, no. 3, 5 March 2007 (2007-03-05), pages 132 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084494A1 (ja) * 2007-12-27 2009-07-09 Public University Corporation Yokohama City University グラム陽性細菌用抗菌剤
JP5618284B2 (ja) * 2007-12-27 2014-11-05 昇一 城武 グラム陽性細菌用抗菌剤
WO2010101178A1 (ja) * 2009-03-03 2010-09-10 公立大学法人横浜市立大学 アミノ酸抱合シアノアクリレートポリマー粒子
CN102361636A (zh) * 2009-03-03 2012-02-22 公立大学法人横浜市立大学 氨基酸接合氰基丙烯酸酯聚合物粒子
JP5663741B2 (ja) * 2009-03-03 2015-02-04 株式会社ナノカム アミノ酸抱合シアノアクリレートポリマー粒子
WO2012133648A1 (ja) 2011-03-31 2012-10-04 Shirotake Shoichi 高次構造体が示す抗細胞効果の新規調整技法
WO2013108871A1 (ja) 2012-01-19 2013-07-25 Shirotake Shoichi 植物病原細菌用抗菌剤
US10351644B2 (en) 2014-02-27 2019-07-16 Shoichi Shirotake Antiviral drug
JP2016056481A (ja) * 2014-09-11 2016-04-21 チカミミルテック株式会社 抗菌性シートおよび抗菌性シートの製造方法
JPWO2016039412A1 (ja) * 2014-09-11 2017-07-13 チカミミルテック株式会社 抗菌剤および抗菌剤の製造方法
WO2016039412A1 (ja) * 2014-09-11 2016-03-17 チカミミルテック株式会社 抗菌剤および抗菌剤の製造方法
JP2017081852A (ja) * 2015-10-28 2017-05-18 チカミミルテック株式会社 抗菌剤および抗菌剤の製造方法
WO2018193847A1 (ja) * 2017-04-18 2018-10-25 チカミミルテック株式会社 藻類増殖抑制剤および藻類の増殖を抑制する方法
JPWO2018193847A1 (ja) * 2017-04-18 2020-03-05 チカミミルテック株式会社 藻類増殖抑制剤および藻類の増殖を抑制する方法
JP7134442B2 (ja) 2017-04-18 2022-09-12 チカミミルテック株式会社 藻類増殖抑制剤および藻類の増殖を抑制する方法
CN107988095A (zh) * 2017-11-27 2018-05-04 华中农业大学 一种高效降解四环素类抗生素的微生物菌剂及应用
CN107988095B (zh) * 2017-11-27 2020-06-02 华中农业大学 一种高效降解四环素类抗生素的微生物菌剂及应用
CN114010797A (zh) * 2021-11-26 2022-02-08 上海交通大学 一种细菌靶向纳米抗菌剂及其制备方法

Also Published As

Publication number Publication date
JPWO2008126846A1 (ja) 2010-07-22
JP4696256B2 (ja) 2011-06-08

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