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WO2008126770A1 - トリアリールカルボン酸誘導体の製造方法 - Google Patents

トリアリールカルボン酸誘導体の製造方法 Download PDF

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Publication number
WO2008126770A1
WO2008126770A1 PCT/JP2008/056708 JP2008056708W WO2008126770A1 WO 2008126770 A1 WO2008126770 A1 WO 2008126770A1 JP 2008056708 W JP2008056708 W JP 2008056708W WO 2008126770 A1 WO2008126770 A1 WO 2008126770A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzene ring
producing
acid derivative
compound
inhibitory effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056708
Other languages
English (en)
French (fr)
Inventor
Masaru Hayashi
Hiroyuki Tsuboi
Junji Sato
Tatsuya Sawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of WO2008126770A1 publication Critical patent/WO2008126770A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明の課題は、優れたキサンチンオキシダーゼ阻害作用に基づく、安全性の高い新規な高尿酸血症、痛風、炎症性腸疾患、糖尿病性腎症、糖尿病性網膜症等の治療又は予防薬を、その工業的に有用な製造方法及び製造中間体により提供することにある。 　本発明者等は、カルボキシル基が置換したアゾール基と、フェニル基がベンゼン環上にパラ位で置換し、さらに当該ベンゼン環にシアノ基を有することを特徴とするトリアリールカルボン酸誘導体が、強力なキサンチンオキシダーゼ阻害作用を有するとの知見に基づき、当該化合物の製造方法につき鋭意検討した結果、アゾール基をベンゼン環と結合させる手法により、当該化合物を効率的に得ることができることを見出し、本発明を完成した。
PCT/JP2008/056708 2007-04-05 2008-04-03 トリアリールカルボン酸誘導体の製造方法 Ceased WO2008126770A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-099936 2007-04-05
JP2007099936 2007-04-05

Publications (1)

Publication Number Publication Date
WO2008126770A1 true WO2008126770A1 (ja) 2008-10-23

Family

ID=39863870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056708 Ceased WO2008126770A1 (ja) 2007-04-05 2008-04-03 トリアリールカルボン酸誘導体の製造方法

Country Status (1)

Country Link
WO (1) WO2008126770A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043568A2 (en) 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2014119681A1 (ja) * 2013-01-31 2014-08-07 帝人ファーマ株式会社 アゾールベンゼン誘導体
WO2014192977A1 (ja) * 2013-05-31 2014-12-04 帝人ファーマ株式会社 チアゾール誘導体
WO2016017826A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 キサンチンオキシダーゼ阻害薬
WO2016017708A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 アゾールベンゼン誘導体およびその結晶
WO2016017696A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 アゾールベンゼン誘導体の結晶
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
CN110204493A (zh) * 2019-07-01 2019-09-06 华南理工大学 三环类xor抑制剂及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003821A1 (en) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Laterally cyano- and fluoro-substituted terphenyls
JPH04327586A (ja) * 1991-03-08 1992-11-17 Merck & Co Inc アンギオテンシンｉｉ拮抗薬としての酸性官能基を有する複素環化合物
WO2007043457A1 (ja) * 2005-10-07 2007-04-19 Astellas Pharma Inc. トリアリールカルボン酸誘導体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003821A1 (en) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Laterally cyano- and fluoro-substituted terphenyls
JPH04327586A (ja) * 1991-03-08 1992-11-17 Merck & Co Inc アンギオテンシンｉｉ拮抗薬としての酸性官能基を有する複素環化合物
WO2007043457A1 (ja) * 2005-10-07 2007-04-19 Astellas Pharma Inc. トリアリールカルボン酸誘導体

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043568A2 (en) 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
WO2014119681A1 (ja) * 2013-01-31 2014-08-07 帝人ファーマ株式会社 アゾールベンゼン誘導体
JP5734532B2 (ja) * 2013-01-31 2015-06-17 帝人ファーマ株式会社 アゾールベンゼン誘導体
KR20150112955A (ko) * 2013-01-31 2015-10-07 데이진 화-마 가부시키가이샤 아졸벤젠 유도체
KR102199258B1 (ko) 2013-01-31 2021-01-06 데이진 화-마 가부시키가이샤 아졸벤젠 유도체
RU2641891C2 (ru) * 2013-01-31 2018-01-23 Тейдзин Фарма Лимитед Азоловые производные бензола
US9388174B2 (en) 2013-01-31 2016-07-12 Teijin Pharma Limited Azole benzene derivative
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
WO2014192977A1 (ja) * 2013-05-31 2014-12-04 帝人ファーマ株式会社 チアゾール誘導体
JPWO2016017826A1 (ja) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 キサンチンオキシダーゼ阻害薬
US10179780B2 (en) 2014-07-30 2019-01-15 Teijin Pharma Limited Azole benzene derivative and crystalline form thereof
JPWO2016017696A1 (ja) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 アゾールベンゼン誘導体の結晶
WO2016017696A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 アゾールベンゼン誘導体の結晶
JPWO2016017708A1 (ja) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 アゾールベンゼン誘導体およびその結晶
CN106661014A (zh) * 2014-07-30 2017-05-10 帝人制药株式会社 唑苯衍生物及其晶体
US9815826B2 (en) 2014-07-30 2017-11-14 Teijin Pharma Limited Crystal of azole benzene derivative
WO2016017708A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 アゾールベンゼン誘導体およびその結晶
RU2675854C2 (ru) * 2014-07-30 2018-12-25 Тейдзин Фарма Лимитед Кристаллическая форма азолбензольного производного
CN106536519A (zh) * 2014-07-30 2017-03-22 帝人制药株式会社 唑苯衍生物的晶体
US10301300B2 (en) 2014-07-30 2019-05-28 Teijin Limited Xanthine oxidase inhibitor
WO2016017826A1 (ja) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 キサンチンオキシダーゼ阻害薬
AU2015297489B2 (en) * 2014-07-30 2019-09-19 Teijin Limited Crystal of azole benzene derivative
RU2701515C2 (ru) * 2014-07-30 2019-09-27 Тейдзин Фарма Лимитед Производное азолобензола и его кристаллическая форма
CN110204493A (zh) * 2019-07-01 2019-09-06 华南理工大学 三环类xor抑制剂及其制备方法和应用
WO2021000527A1 (zh) * 2019-07-01 2021-01-07 华南理工大学 三环类xor抑制剂及其制备方法和应用
CN110204493B (zh) * 2019-07-01 2021-05-14 华南理工大学 三环类xor抑制剂及其制备方法和应用

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