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WO2008124825A3 - Polyéthylène réticulé de très haut poids moléculaire stabilisé par des antioxydants pour des applications dans des dispositifs médicaux - Google Patents

Polyéthylène réticulé de très haut poids moléculaire stabilisé par des antioxydants pour des applications dans des dispositifs médicaux Download PDF

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Publication number
WO2008124825A3
WO2008124825A3 PCT/US2008/059909 US2008059909W WO2008124825A3 WO 2008124825 A3 WO2008124825 A3 WO 2008124825A3 US 2008059909 W US2008059909 W US 2008059909W WO 2008124825 A3 WO2008124825 A3 WO 2008124825A3
Authority
WO
WIPO (PCT)
Prior art keywords
uhmwpe
antioxidant
molecular weight
medical device
high molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/059909
Other languages
English (en)
Other versions
WO2008124825A2 (fr
Inventor
Dirk Pletcher
Hallie E. Brinkerhuff
Werner Schneider
Ray Gsell
Toni Rowe
Alicia Rufner
John Knight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zimmer Inc
Original Assignee
Zimmer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2678459A priority Critical patent/CA2678459C/fr
Priority to AU2008236996A priority patent/AU2008236996B2/en
Priority to ES08745507T priority patent/ES2378721T3/es
Priority to JP2010503206A priority patent/JP2010523805A/ja
Priority to EP08745507A priority patent/EP2150285B1/fr
Priority to EP12167580.5A priority patent/EP2564882B1/fr
Application filed by Zimmer Inc filed Critical Zimmer Inc
Priority to AT08745507T priority patent/ATE544476T1/de
Priority to EP12167581.3A priority patent/EP2578248B1/fr
Publication of WO2008124825A2 publication Critical patent/WO2008124825A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008124825A3 publication Critical patent/WO2008124825A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A61B17/8085—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates with pliable or malleable elements or having a mesh-like structure, e.g. small strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/143—Stabilizers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/26—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking
    • C08L2312/06—Crosslinking by radiation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31—Surface property or characteristic of web, sheet or block
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31—Surface property or characteristic of web, sheet or block
    • Y10T428/315—Surface modified glass [e.g., tempered, strengthened, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

L'invention concerne le mélange d'un antioxydant avec du UHMWPE avant de soumettre le UHMWPE à une irradiation de réticulation. Selon un mode de réalisation, l'antioxydant est le tocophérol. Après le mélange de l'antioxydant avec le UHMWPE, le mélange résultant peut être mis sous la forme de tablettes, de blocs et/ou incorporé dans un substrat, tel qu'un métal par exemple. Le produit résultant peut ensuite être soumis à une irradiation de réticulation. Selon un mode de réalisation, le mélange UHMWPE est préchauffé avant d'être soumis à une irradiation de réticulation. Une fois irradié, le mélange UHMWPE peut être usiné, emballé et stérilisé selon des techniques classiques.
PCT/US2008/059909 2007-04-10 2008-04-10 Polyéthylène réticulé de très haut poids moléculaire stabilisé par des antioxydants pour des applications dans des dispositifs médicaux Ceased WO2008124825A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2008236996A AU2008236996B2 (en) 2007-04-10 2008-04-10 An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
ES08745507T ES2378721T3 (es) 2007-04-10 2008-04-10 Polietileno reticulado de peso molecular ultra alto estabilizado por antioxidantes para aplicaciones en dispositivos médicos
JP2010503206A JP2010523805A (ja) 2007-04-10 2008-04-10 医療機器用途のための、酸化防止剤で安定化された架橋超高分子量ポリエチレン
EP08745507A EP2150285B1 (fr) 2007-04-10 2008-04-10 Polyéthylène réticulé de très haut poids moléculaire stabilisé par des antioxydants pour des applications dans des dispositifs médicaux
EP12167580.5A EP2564882B1 (fr) 2007-04-10 2008-04-10 Polyéthylène antioxydant, réticulé, stabilisé, à poids moléculaire très élevé pour des applications de dispositifs médicaux
CA2678459A CA2678459C (fr) 2007-04-10 2008-04-10 Polyethylene reticule de tres haut poids moleculaire stabilise par des antioxydants pour des applications dans des dispositifs medicaux
AT08745507T ATE544476T1 (de) 2007-04-10 2008-04-10 Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten
EP12167581.3A EP2578248B1 (fr) 2007-04-10 2008-04-10 Polyéthylène antioxydant, réticulé, stabilisé, à poids moléculaire très élevé pour des applications de dispositifs médicaux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92273807P 2007-04-10 2007-04-10
US60/922,738 2007-04-10

Publications (2)

Publication Number Publication Date
WO2008124825A2 WO2008124825A2 (fr) 2008-10-16
WO2008124825A3 true WO2008124825A3 (fr) 2009-12-17

Family

ID=39540499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/059909 Ceased WO2008124825A2 (fr) 2007-04-10 2008-04-10 Polyéthylène réticulé de très haut poids moléculaire stabilisé par des antioxydants pour des applications dans des dispositifs médicaux

Country Status (8)

Country Link
US (6) US20080319137A1 (fr)
EP (4) EP2564882B1 (fr)
JP (1) JP2010523805A (fr)
AT (1) ATE544476T1 (fr)
AU (1) AU2008236996B2 (fr)
CA (1) CA2678459C (fr)
ES (2) ES2378721T3 (fr)
WO (1) WO2008124825A2 (fr)

Cited By (6)

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US9708467B2 (en) 2013-10-01 2017-07-18 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
US9822224B2 (en) 2007-04-10 2017-11-21 Zimmer, Inc. Antioxidant stabilized crosslinked ultra high molecular weight polyethylene for medical device applications
US9926432B2 (en) 2007-04-10 2018-03-27 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US10184031B2 (en) 2014-03-12 2019-01-22 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US10265891B2 (en) 2014-12-03 2019-04-23 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
US11001680B2 (en) 2005-08-18 2021-05-11 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles

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