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WO2008123607A1 - Method for production of dipeptide - Google Patents

Method for production of dipeptide Download PDF

Info

Publication number
WO2008123607A1
WO2008123607A1 PCT/JP2008/056755 JP2008056755W WO2008123607A1 WO 2008123607 A1 WO2008123607 A1 WO 2008123607A1 JP 2008056755 W JP2008056755 W JP 2008056755W WO 2008123607 A1 WO2008123607 A1 WO 2008123607A1
Authority
WO
WIPO (PCT)
Prior art keywords
dipeptide
protein
producing
synthesizing activity
transformant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056755
Other languages
French (fr)
Japanese (ja)
Inventor
Kuniki Kino
Atsushi Noguchi
Yuji Nakazawa
Akihiro Senoo
Makoto Yagasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Hakko Bio Co Ltd
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Kyowa Hakko Bio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Kyowa Hakko Bio Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of WO2008123607A1 publication Critical patent/WO2008123607A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed are: a protein having a dipeptide-synthesizing activity; DNA encoding the protein; recombinant DNA comprising the DNA; a transformant transformed with the recombinant DNA; a method for producing a protein having a dipeptide-synthesizing activity by using the transformant or the like; a method for producing a dipeptide by using a protein having a dipeptide-synthesizing activity; and a method for producing a dipeptide by using a transformant capable of producing a protein having a dipeptide-synthesizing activity, a culture of a microorganism capable of producing a protein having a dipeptide-synthesizing activity or the like as an enzyme source.
PCT/JP2008/056755 2007-04-04 2008-04-04 Method for production of dipeptide Ceased WO2008123607A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-098180 2007-04-04
JP2007098180 2007-04-04

Publications (1)

Publication Number Publication Date
WO2008123607A1 true WO2008123607A1 (en) 2008-10-16

Family

ID=39831062

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056755 Ceased WO2008123607A1 (en) 2007-04-04 2008-04-04 Method for production of dipeptide

Country Status (1)

Country Link
WO (1) WO2008123607A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058960A1 (en) * 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptide
WO2005103260A1 (en) * 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptide
WO2006101023A1 (en) * 2005-03-18 2006-09-28 Kyowa Hakko Kogyo Co., Ltd. Method for producing dipeptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058960A1 (en) * 2002-12-26 2004-07-15 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptide
WO2005103260A1 (en) * 2004-04-21 2005-11-03 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptide
WO2006101023A1 (en) * 2005-03-18 2006-09-28 Kyowa Hakko Kogyo Co., Ltd. Method for producing dipeptide

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 19 October 2006 (2006-10-19), DUCHAUD E. ET AL.: "Photorhabdus luminescens subsp. laumondii TTO1 complete genome", Database accession no. (BX571863) *
DUCHAUD E. ET AL.: "The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens", NAT. BIOTECHNOL., vol. 21, no. 11, 2003, pages 1307 - 1313, XP002412298 *
KINO K., NAKAZAWA Y., YAGASAKI M.: "Dipeptide synthesis by 1-amino acid ligase from Ralstonia solanacearum", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 371, no. 3, 2008, pages 536 - 540, XP022670737 *
KINO K.: "Seiri Kassei Peptide Amino-san Renketsu Koso no Tansaku to Dipeptide Gosei eno Riyo", BIO INDUSTRY, vol. 23, no. 9, 2006, pages 59 - 67 *
TABATA K. ET AL.: "ywfE in Bacillus subtilis codes for a novel enzyme, L-amino acid ligase", J. BACTERIOL., vol. 187, no. 15, 2005, pages 5195 - 5202, XP008054400 *

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