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WO2008122101A1 - Composition favorisant le sommeil et le calme, comprenant des extraits de houblon, d'eclipta alba et de nordostachys jatamansi - Google Patents

Composition favorisant le sommeil et le calme, comprenant des extraits de houblon, d'eclipta alba et de nordostachys jatamansi Download PDF

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Publication number
WO2008122101A1
WO2008122101A1 PCT/CA2007/000577 CA2007000577W WO2008122101A1 WO 2008122101 A1 WO2008122101 A1 WO 2008122101A1 CA 2007000577 W CA2007000577 W CA 2007000577W WO 2008122101 A1 WO2008122101 A1 WO 2008122101A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
sleep
individual
extract
hops
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2007/000577
Other languages
English (en)
Inventor
Marvin Heuer
Ken Clement
Shan Chaudhuri
Megan Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iomedix Development International SRL
Original Assignee
Iomedix Development International SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iomedix Development International SRL filed Critical Iomedix Development International SRL
Priority to PCT/CA2007/000577 priority Critical patent/WO2008122101A1/fr
Publication of WO2008122101A1 publication Critical patent/WO2008122101A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3486—Humulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Definitions

  • Composition for promoting sleep and calmness comprising an extract of Hops, Eclipta alba and Nordostachys jatamansi
  • the present invention is directed towards supplemental compositions and methods for promoting restful sleep in an individual by producing a feeling of calmness.
  • the regulation of sleep in humans is governed by three processes - each influenced by hormonal and environmental factors: a daily sleep- wake cycle influenced by a circadian rhythm (24 hour cycle) tied to light-dark cycles.
  • the need for sleep is a biological drive similar to thirst or hunger.
  • insomnia is estimated to affect a significant portion of the population every year and is associated with health problems and concomitant economic losses to society (Stoller MK. Economic effects of insomnia. Clin Ther. 1994 Sep-Oct;16(5):873-97 Abstract). It is clear that the impairment of sleep is detrimental to one's health. In humans, mild sleep deprivation results in indications of impaired immune system function (Irwin M, McClintick J, Costlow C, Former M, White J, Gillin JC. Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB J. 1996 Apr;10(5):643-53). Prolonged sleep deprivation is even known to result in death. It has been determined by many that an individual can survive longer without food than one can without sleep; thus indicating the importance of sleep.
  • the present invention is directed towards a composition for promoting feeling of calmness in an individual comprising and extract of Hops, Eclipta alba powder, and Nardostachys jatamansi.
  • a method for promoting a restful period of sleep via an induction of a calming feeling in an individual comprising the step of administration of, to an individual, a composition comprising Hops, Eclipta alba powder, and Nardostachys jatamansi to produce a feeling of calmness.
  • the term 'sleep' for the purposes of the present invention is defined as a natural or artificially induced state of suspension of sensory and motor activity in an individual.
  • improvements in sleep may be both of a quantitative nature e.g. an increase in the length of sleep, a decreased in the time of sleep onset, and of a qualitative nature e.g. a deeper, more restful undisturbed period of sleep. It is further understood that improvements in sleep may also be both direct and indirect. For example, sleep will be directly improved by the administration of a substance which is known to reduce the time to sleep onset. Sleep may be indirectly improved, for example, by the administration of a substance which is known to result in feelings of relaxation and calmness. It is an aspect of the present invention to provide an individual consuming a composition of the present invention herein disclosed with an induced feeling of calmness, thus leading to improved sleep.
  • Hops (Hamulus lupulus)
  • the Hop plant (Humulus lupulus) is a flowering vine used traditionally as a sedative for anxiety and sleep difficulties.
  • Hops extract has been shown to have sleep-enhancing and antidepressant activities (Zanoli P, Rivasi M, Zavatti M, Brusiani F, Baraldi M. New insight in the neuropharmacological activity of Humulus lupulus L. J Ethnopharmacol. 2005 Oct 31;102(l):102-6).
  • administration of Hops extract has been shown to produce sedative effects (Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H. Related Sedating effects of Humulus lupulus L. extracts.
  • Hops extract has been shown to modulate the gamma-aminobutyric acid receptor (GABA(A) receptors) and display GABA-like activity (Aoshima H, Takeda K, Okita Y, Hossain SJ, Koda H, Kiso Y. Effects of beer and hop on ionotropic gamma- aminobutyric acid receptors. J Agric Food Chem. 2006 Apr 5;54(7):2514-9); the mechanism at least in part responsible for the aforementioned effects.
  • GABA is an inhibitory neurotransmitter that can induce relaxation and sleep. Modulation of any or all of these receptors may mediate the sleep-inducing activity of Hops.
  • the composition comprises an extract of Hops to promote a feeling of calmness and sedation through modulation of GABA-signaling.
  • a serving of the supplemental composition comprises from about 0.001 g to about 0.500 g of an extract of Hops.
  • the preferred dosage of an extract of Hops in the present invention comprises about 0.120 g. per serving.
  • Eclipta alba plant grows as a weed in Asia and South America. It has been used in traditional medicine for many treatments. Eclipta alba extract has been shown to possess nootropic effects and attenuate stress-induced neurochemical changes in animal studies (Thakur VD, Mengi SA. Neuropharmacological profile of Eclipta alba (Linn.) Hassk. J Ethnopharmacol. 2005 Oct 31;102(l):23-31 Abstract) as well as have analgesic effects (Sawant M, Isaac JC, Narayanan S. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. Phytother Res. 2004 Feb;18(2):l 11-3 Abstract).
  • the composition comprises Eclipta alba powder to reduce the effects of stress conducive to a feeling of calmness.
  • a serving of the supplemental composition comprises from about 0.001 g to about 0.100 g of Eclipta alba powder.
  • the preferred dosage of Eclipta alba powder in the present invention comprises about 0.005 g per serving.
  • Nardostachys jatamansi herb is part of traditional Indian medicine where it is used for treatments affecting the central nervous system, particularly for depressant action (Joshi H, Parle M. Nardostachys jatamansi improves learning and memory in mice. J Med Food. 2006 Spring;9(l): 113-8).
  • Serotonin is a neurochemical, concentrated in the raphe nucleus region of the brain wherein its axon project into several areas of the brain such as the hypothalamus.
  • serotonin is understood to be involved in inducing sleep and control of mood, among other function, hi fact, many well-known antidepressants act by inducing serotonin release or inhibiting its re-uptake in the brains. It is herein understood by the inventors that increasing the amount of serotonin is beneficial to induce sleep and promote a feeling of calmness in an individual.
  • the composition comprises Nardostachys jatamansi to aid in promoting a feeling of calmness, an good mood and induce sleep in an individual following administration.
  • a serving of the supplemental composition comprises from about 0.001 g to about 0.100 g of Nardostachys jatamansi extract.
  • the preferred dosage of Nardostachys jatamansi extract in the present invention comprises about 0.020 g per serving.
  • the composition comprises an extract of Hops, Eclipta alba powder, and Nardostachys jatamansi for the promotion of a restful period of sleep in an individual by producing a feeling of calmness.
  • the nutritional supplement may be consumed in any form.
  • the dosage form of the nutritional supplement may be provided as, e.g., a powder beverage mix, a liquid beverage, a ready-to-eat bar or drink product, a capsule, a liquid capsule, a tablet, a caplet, or as a dietary gel.
  • the preferred dosage forms of the present invention are as a tablet or caplet.
  • the composition may be provided in a solid dosage form with specific controlled release characteristics.
  • the composition may be provided in a layered solid dosage form.
  • each individual layer will provide unique dissolution characteristics.
  • each layer may contain a homogeneous mixture of ingredients whereby the release of the ingredients is dependent upon the characteristics of layer to which the ingredients are included.
  • each layer may contain a distinct set of specific ingredients which differ according to the layer such that different specific ingredients are released at different times. In all aspects of this embodiment, a temporally controlled release of ingredients is achieved.
  • the dosage form of the nutritional supplement may be provided in accordance with customary processing techniques for herbal and nutritional supplements in any of the forms mentioned above. Additionally, the nutritional supplement set forth in the example embodiment herein may contain any appropriate number and type of excipients, as is well known in the art.
  • the present nutritional composition or those similarly envisioned by one of skill in the art may be utilized in methods to promote and support a restful period of sleep in an individual. By way of ingestion of the composition of the present invention, a method for the promotion of restful sleep in an individual through inducing a feeling of calmness in an individual is provided. The method of the present invention comprises at least the step of administering to an individual a therapeutically acceptable amount of the composition of the present invention.
  • the present composition may be used not only as a sole means of promoting and supporting restful sleep but may also be used either in addition to other similarly-directed compositions or as a component of a larger composition.
  • a nutritional supplement to help promote restful, quality sleep for use immediately prior to bedtime is provided in the following the composition.
  • a serving of the nutritional supplement as a caplet contains the following ingredients: [0026] About 0.12O g of an extract of Hops, about 0.005 g of, about 0.005 g of
  • Eclipta alba powder and about 0.020 g of Nardostachys jatamansi.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Méthode favorisant un sommeil tranquille, de qualité chez un individu, qui consiste en l'administration d'extrait de houblon, d'extrait en poudre d'Eclipta alba et d'extrait de Nardostachys jatamansi.
PCT/CA2007/000577 2007-04-05 2007-04-05 Composition favorisant le sommeil et le calme, comprenant des extraits de houblon, d'eclipta alba et de nordostachys jatamansi Ceased WO2008122101A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CA2007/000577 WO2008122101A1 (fr) 2007-04-05 2007-04-05 Composition favorisant le sommeil et le calme, comprenant des extraits de houblon, d'eclipta alba et de nordostachys jatamansi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2007/000577 WO2008122101A1 (fr) 2007-04-05 2007-04-05 Composition favorisant le sommeil et le calme, comprenant des extraits de houblon, d'eclipta alba et de nordostachys jatamansi

Publications (1)

Publication Number Publication Date
WO2008122101A1 true WO2008122101A1 (fr) 2008-10-16

Family

ID=39830426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2007/000577 Ceased WO2008122101A1 (fr) 2007-04-05 2007-04-05 Composition favorisant le sommeil et le calme, comprenant des extraits de houblon, d'eclipta alba et de nordostachys jatamansi

Country Status (1)

Country Link
WO (1) WO2008122101A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12213505B2 (en) 2021-07-05 2025-02-04 Healthy Ingredient Solutions, LLC Composition for promoting restful sleep and methods of making and using the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FARAG N.H. AND MILLS P.J.: "A randomized-controlled trial of the effects of a traditional herbal supplement on sleep onset insomnia", COMPLEMENTARY THERAPIES IN MEDICINE, vol. 11, 2003, pages 223 - 225 *
MORIN C.M. ET AL.: "Valerian hops combination and diphenylhydramine for treating insomnia: a randomized placebo-controlled clinical trial", SLEEP, vol. 28, 2005, pages 1465 - 1471 *
SAWANT M. ET AL.: "Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk", PHYTOTHERAPY RESEARCH, vol. 18, 2004, pages 111 *
SCHILLER H. ET AL.: "Sedating effects of Humulus lupulus L. extracts", PHYTOMEDICINE, vol. 13, 2006, pages 535 - 541, XP005607002 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12213505B2 (en) 2021-07-05 2025-02-04 Healthy Ingredient Solutions, LLC Composition for promoting restful sleep and methods of making and using the same

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