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WO2008121788A3 - Haplotypes of lipoprotein lipase, visceral adiposity and fasting insulin levels - Google Patents

Haplotypes of lipoprotein lipase, visceral adiposity and fasting insulin levels Download PDF

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Publication number
WO2008121788A3
WO2008121788A3 PCT/US2008/058605 US2008058605W WO2008121788A3 WO 2008121788 A3 WO2008121788 A3 WO 2008121788A3 US 2008058605 W US2008058605 W US 2008058605W WO 2008121788 A3 WO2008121788 A3 WO 2008121788A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
insulin levels
lipoprotein lipase
individual
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/058605
Other languages
French (fr)
Other versions
WO2008121788A2 (en
Inventor
Mark O Goodarzi
Kent D Taylor
Xiuqing Guo
Jinrui Cui
Jerome I Rotter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of WO2008121788A2 publication Critical patent/WO2008121788A2/en
Publication of WO2008121788A3 publication Critical patent/WO2008121788A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides various methods of diagnosing susceptibility to and/or protection against conditions associated with insulin resistance syndrome in an individual. In one embodiment, the present invention provides a method of determining protection against insulin resistance syndrome in an individual by determining the presence of haplotype (1) at the LPL locus. In another embodiment, the present invention provides a method of determining susceptibility to insulin resistance syndrome in an individual by determining the presence of haplotype (2) at the LPL locus and/or haplotype (4) at the LPL locus. In another embodiment, the individual is Hispanic.
PCT/US2008/058605 2007-03-30 2008-03-28 Haplotypes of lipoprotein lipase, visceral adiposity and fasting insulin levels Ceased WO2008121788A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90926907P 2007-03-30 2007-03-30
US60/909,269 2007-03-30

Publications (2)

Publication Number Publication Date
WO2008121788A2 WO2008121788A2 (en) 2008-10-09
WO2008121788A3 true WO2008121788A3 (en) 2008-11-27

Family

ID=39808868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/058605 Ceased WO2008121788A2 (en) 2007-03-30 2008-03-28 Haplotypes of lipoprotein lipase, visceral adiposity and fasting insulin levels

Country Status (1)

Country Link
WO (1) WO2008121788A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8178294B2 (en) 2002-06-14 2012-05-15 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
WO2010051483A1 (en) * 2008-10-31 2010-05-06 Cedars-Sinai Medical Center Methods of diagnosing insulin resistance and sensitivity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOODARZI M. ET AL.: "Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans", DIABETES, vol. 53, January 2004 (2004-01-01), pages 214 - 220 *
GOODARZI M.O. ET AL.: "Haplotypes in the Lipoprotein Lipase Gene Influence Fasting Insulin and Discovery of a New Risk Haplotype", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 92, January 2007 (2007-01-01), pages 293 - 296 *

Also Published As

Publication number Publication date
WO2008121788A2 (en) 2008-10-09

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