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WO2008120263A3 - Prokineticins receptors antagonists, derivatives and uses thereof - Google Patents

Prokineticins receptors antagonists, derivatives and uses thereof Download PDF

Info

Publication number
WO2008120263A3
WO2008120263A3 PCT/IT2008/000216 IT2008000216W WO2008120263A3 WO 2008120263 A3 WO2008120263 A3 WO 2008120263A3 IT 2008000216 W IT2008000216 W IT 2008000216W WO 2008120263 A3 WO2008120263 A3 WO 2008120263A3
Authority
WO
WIPO (PCT)
Prior art keywords
prokineticins
derivatives
receptors antagonists
receptors
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2008/000216
Other languages
French (fr)
Other versions
WO2008120263A2 (en
Inventor
Lucia Negri
Donatella Barra
Pietro Malchiorri
Rossella Miele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Roma La Sapienza
Original Assignee
Universita degli Studi di Roma La Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Roma La Sapienza filed Critical Universita degli Studi di Roma La Sapienza
Publication of WO2008120263A2 publication Critical patent/WO2008120263A2/en
Publication of WO2008120263A3 publication Critical patent/WO2008120263A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to peptides derived from the protein Bv8 having an antagonist activity for the prokineticins receptors PKRl and PKR2, with no hyperalgesic activity, and their use in the treatment of pain.
PCT/IT2008/000216 2007-04-03 2008-04-01 Prokineticins receptors antagonists, derivatives and uses thereof Ceased WO2008120263A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM20070182 ITRM20070182A1 (en) 2007-04-03 2007-04-03 ANTAGONISTS OF THE PROCHINETICINE RECEPTORS DERIVED FROM THEM AND THEIR USE
ITRM2007A000182 2007-04-03

Publications (2)

Publication Number Publication Date
WO2008120263A2 WO2008120263A2 (en) 2008-10-09
WO2008120263A3 true WO2008120263A3 (en) 2008-12-18

Family

ID=39740059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2008/000216 Ceased WO2008120263A2 (en) 2007-04-03 2008-04-01 Prokineticins receptors antagonists, derivatives and uses thereof

Country Status (2)

Country Link
IT (1) ITRM20070182A1 (en)
WO (1) WO2008120263A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008002782A1 (en) 2007-09-21 2009-07-31 Genentech Inc Neutralizing anti-bv8 antibody; composition comprising it; and its use to treat tumors in humans previously treated with a vascular endothelial growth factor antagonist.
CA2803539A1 (en) * 2010-06-28 2012-01-12 Janssen Pharmaceutica Nv Prokineticin 1 receptor antagonists for the treatment of pain
EP2585069A1 (en) * 2010-06-28 2013-05-01 Janssen Pharmaceutica, N.V. Prokineticin 1 receptor antagonists for the treatment of pain
WO2014078306A1 (en) 2012-11-13 2014-05-22 Regeneron Pharmaceuticals, Inc. Anti-prokineticin receptor (prokr) antibodies and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087054A2 (en) * 2003-03-25 2004-10-14 The Regents Of The University Of California Methods for modulating gastric secretion using prokineticin receptor antagonists.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087054A2 (en) * 2003-03-25 2004-10-14 The Regents Of The University Of California Methods for modulating gastric secretion using prokineticin receptor antagonists.

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BERGER V ET AL: "Transport mechanisms of the large neutral amino acid L-phenylalanine in the human intestinal epithelial caco-2 cell line.", THE JOURNAL OF NUTRITION NOV 2000, vol. 130, no. 11, November 2000 (2000-11-01), pages 2780 - 2788, XP002497333, ISSN: 0022-3166 *
BULLOCK C M ET AL: "STRUCTURAL DETERMINANTS REQUIRED FOR THE BIOACTIVITIES OF PROKINETICINS AND IDENTIFICATION OF PROKINETICIN RECEPTOR ANTAGONISTS", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 65, no. 3, 1 March 2004 (2004-03-01), pages 582 - 588, XP008028638, ISSN: 0026-895X *
LAI REN ET AL: "Two novel Bv8-like peptides from skin secretions of the toad Bombina maxima.", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY MAR 2003, vol. 134, no. 3, March 2003 (2003-03-01), pages 509 - 514, XP002497330, ISSN: 1096-4959 *
MOLLAY ET AL: "Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER BV, NL, vol. 374, no. 2, 18 June 1999 (1999-06-18), pages 189 - 196, XP002123181, ISSN: 0014-2999 *
NEGRI L ET AL: "Nociceptive sensitization by the secretory protein Bv8", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, vol. 137, no. 8, 1 December 2002 (2002-12-01), pages 1147 - 1154, XP002371986, ISSN: 0007-1188 *
NEGRI LUCIA ET AL: "Biological activities of Bv8 analogues.", BRITISH JOURNAL OF PHARMACOLOGY NOV 2005, vol. 146, no. 5, November 2005 (2005-11-01), pages 625 - 632, XP002497331, ISSN: 0007-1188 *
NEGRI LUCIA ET AL: "Modulators of pain: BV8 and prokineticins", CURRENT NEUROPHARMACOLOGY, vol. 4, no. 3, July 2006 (2006-07-01), pages 207 - 215, XP002497332, ISSN: 1570-159X *

Also Published As

Publication number Publication date
WO2008120263A2 (en) 2008-10-09
ITRM20070182A1 (en) 2008-10-04

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