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WO2008119882A3 - Screening methods based on human adam12 polypeptide and binding agents thereof - Google Patents

Screening methods based on human adam12 polypeptide and binding agents thereof Download PDF

Info

Publication number
WO2008119882A3
WO2008119882A3 PCT/FI2008/050146 FI2008050146W WO2008119882A3 WO 2008119882 A3 WO2008119882 A3 WO 2008119882A3 FI 2008050146 W FI2008050146 W FI 2008050146W WO 2008119882 A3 WO2008119882 A3 WO 2008119882A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding agents
screening methods
methods based
human adam12
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FI2008/050146
Other languages
French (fr)
Other versions
WO2008119882A2 (en
WO2008119882A8 (en
Inventor
Mikko Suonpaeae
Paeivi Aronkytoe
Pertti Hurskainen
Outi Mulari
Jarkko Karvinen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wallac Oy
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Publication of WO2008119882A2 publication Critical patent/WO2008119882A2/en
Publication of WO2008119882A3 publication Critical patent/WO2008119882A3/en
Publication of WO2008119882A8 publication Critical patent/WO2008119882A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a novel epitope of human ADAM12 and to binding agents, preferably to Fab fragments, specifically binding to said epitope. The invention also relates to a method for detecting ADAM 12 in a biological sample using said binding agents, and to prenatal screening methods and diagnostic methods using said binding agents.
PCT/FI2008/050146 2007-03-30 2008-03-28 Screening methods based on human adam12 polypeptide and binding agents thereof Ceased WO2008119882A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FI20075209 2007-03-30
FI20075209 2007-03-30
US90748507P 2007-04-04 2007-04-04
US60/907,485 2007-04-04

Publications (3)

Publication Number Publication Date
WO2008119882A2 WO2008119882A2 (en) 2008-10-09
WO2008119882A3 true WO2008119882A3 (en) 2008-11-20
WO2008119882A8 WO2008119882A8 (en) 2009-07-30

Family

ID=39720517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2008/050146 Ceased WO2008119882A2 (en) 2007-03-30 2008-03-28 Screening methods based on human adam12 polypeptide and binding agents thereof

Country Status (1)

Country Link
WO (1) WO2008119882A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114008079A (en) * 2019-03-20 2022-02-01 贾夫林肿瘤学公司 anti-ADAM12 antibodies and chimeric antigen receptors, and compositions and methods comprising the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009430A2 (en) * 1995-09-05 1997-03-13 Celltech Therapeutics Limited A human metalloproteinase, variants thereof and dna sequences codding therefor
US20020147132A1 (en) * 1996-02-23 2002-10-10 Mochida Pharmaceutical Co., Ltd. Meltrins
EP1524523A1 (en) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Use of ADAM 12 for diagnosis and therapy of preeclampsia
WO2005071387A1 (en) * 2004-01-09 2005-08-04 Children's Medical Center Coporation Methods for diagnosis and pronosis of cancers of epithelial origin
US20060134654A1 (en) * 2004-05-19 2006-06-22 Wewer Ulla M ADAM12, a novel marker for abnormal cell function

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009430A2 (en) * 1995-09-05 1997-03-13 Celltech Therapeutics Limited A human metalloproteinase, variants thereof and dna sequences codding therefor
US20020147132A1 (en) * 1996-02-23 2002-10-10 Mochida Pharmaceutical Co., Ltd. Meltrins
EP1524523A1 (en) * 2003-10-17 2005-04-20 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Use of ADAM 12 for diagnosis and therapy of preeclampsia
WO2005071387A1 (en) * 2004-01-09 2005-08-04 Children's Medical Center Coporation Methods for diagnosis and pronosis of cancers of epithelial origin
US20060134654A1 (en) * 2004-05-19 2006-06-22 Wewer Ulla M ADAM12, a novel marker for abnormal cell function

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARL-MCGRATH STACY ET AL: "The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 26, no. 1, 1 January 2005 (2005-01-01), pages 17 - 24, XP009105604, ISSN: 1019-6439 *
IGARASHI ET AL: "Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 581, no. 13, 29 May 2007 (2007-05-29), pages 2416 - 2422, XP022086940, ISSN: 0014-5793 *
SEALS DARREN F ET AL: "The ADAMs family of metalloproteases: Multidomain proteins with multiple functions", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 17, no. 1, 1 January 2003 (2003-01-01), pages 7 - 30, XP002459610, ISSN: 0890-9369 *
YAMAMOTO S ET AL: "ADAM family proteins in the immune system", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 20, no. 6, 1 June 1999 (1999-06-01), pages 278 - 284, XP004169720, ISSN: 0167-5699 *

Also Published As

Publication number Publication date
WO2008119882A2 (en) 2008-10-09
WO2008119882A8 (en) 2009-07-30

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