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WO2008117796A1 - 新規ムチリン誘導体 - Google Patents

新規ムチリン誘導体 Download PDF

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Publication number
WO2008117796A1
WO2008117796A1 PCT/JP2008/055566 JP2008055566W WO2008117796A1 WO 2008117796 A1 WO2008117796 A1 WO 2008117796A1 JP 2008055566 W JP2008055566 W JP 2008055566W WO 2008117796 A1 WO2008117796 A1 WO 2008117796A1
Authority
WO
WIPO (PCT)
Prior art keywords
general formula
amino
mutilin derivatives
lower alkyl
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/055566
Other languages
English (en)
French (fr)
Inventor
Yoshimi Hirokawa
Shiro Kato
Hironori Kinoshita
Tomoyuki Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of WO2008117796A1 publication Critical patent/WO2008117796A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

　本発明は多剤耐性菌に対する抗菌剤として有用な下記式（Ｉ）で表されるムチリン誘導体およびその製造中間体等に関する。式（Ｉ）においてＲ1はビニル基等を、Ｐ1はＨ、ＯＨ基の保護基等を、Ｒ2、Ｒ3はＨ等を、Ｇは低級アルキレン鎖を、Ａは単結合等を、Ｑ1環は飽和ヘテロ環を、Ｒ4、Ｒ5はＨ、低級アルキル基等を、Ｗは下記式（Ｗ-１）で表される基、アミノ保護基またはＨを意味し、下記式（Ｗ-１）においてＢは-ＣＯ-等を、Ｘは低級アルキレン鎖等を、Ｚ1はＣＨ等を、Ｚ2、Ｚ3、Ｚ4はＮ等を、Ｙ1、Ｙ2はＨ、アミノ基、下記式（Ｙ-１）で表される基等を意味し、下記式（Ｙ-１）においてＱ2環は飽和ヘテロ環を、Ｒ7、Ｒ8はＨ、低級アルキル基等を意味する。
PCT/JP2008/055566 2007-03-28 2008-03-25 新規ムチリン誘導体 Ceased WO2008117796A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007085971 2007-03-28
JP2007-085971 2007-03-28

Publications (1)

Publication Number Publication Date
WO2008117796A1 true WO2008117796A1 (ja) 2008-10-02

Family

ID=39788530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055566 Ceased WO2008117796A1 (ja) 2007-03-28 2008-03-25 新規ムチリン誘導体

Country Status (1)

Country Link
WO (1) WO2008117796A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011125684A1 (ja) * 2010-03-31 2011-10-13 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、重合体及び化合物
CN102372717A (zh) * 2010-08-20 2012-03-14 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
US8182842B1 (en) 2010-11-10 2012-05-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Physico-chemical-managed killing of penicillin-resistant static and growing gram-positive and gram-negative vegetative bacteria
CN102924390A (zh) * 2012-09-07 2013-02-13 苏州康润医药有限公司 1,5-二氮杂环辛烷-1-甲酸叔丁酯的合成方法
CN103265442A (zh) * 2013-06-05 2013-08-28 北京理工大学 一类新型截短侧耳素衍生物及其制备方法和抗肿瘤用途
US9585886B2 (en) 2010-12-16 2017-03-07 Calchan Limited ASK1 inhibiting pyrrolopyrimidine derivatives
US9701628B2 (en) 2014-01-22 2017-07-11 Nabriva Therapeutics Ag 12-epi pleuromutilins
CN108484424A (zh) * 2018-04-08 2018-09-04 中国农业科学院兰州畜牧与兽药研究所 侧链含有季铵盐基团的截短侧耳素类衍生物及其用途
US10111875B2 (en) 2010-08-20 2018-10-30 Hutchinson Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
CN109195608A (zh) * 2016-03-02 2019-01-11 比尔及梅琳达盖茨基金会 含硼小分子
US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
CN110467603A (zh) * 2019-07-08 2019-11-19 华南农业大学 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用
CN111793044A (zh) * 2020-07-21 2020-10-20 西华大学 哌嗪脲截短侧耳素衍生物及其用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278674A (en) * 1971-10-05 1981-07-14 Sandoz Ltd. Substituted 14-desoxy-mutilin compositions
WO1999021855A1 (en) * 1997-10-29 1999-05-06 Smithkline Beecham P.L.C. Pleuromutilin derivatives as antimicrobials
WO2000007974A1 (en) * 1998-08-05 2000-02-17 Smithkline Beecham P.L.C. 2-fluoro mutilin derivatives
WO2000037074A1 (en) * 1998-12-18 2000-06-29 Smithkline Beecham Plc Mutilin 14-ester derivatives having antibacterial activity
WO2002030929A1 (en) * 2000-10-10 2002-04-18 Smithkline Beecham P.L.C. Novel pleuromutilin derivatives
WO2002038528A1 (en) * 2000-11-11 2002-05-16 Smithkline Beecham P.L.C. Pleuromutilin derivatives with antimicrobial activity
WO2007037518A1 (ja) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. ムチリン誘導体及びそれを含有する医薬組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278674A (en) * 1971-10-05 1981-07-14 Sandoz Ltd. Substituted 14-desoxy-mutilin compositions
WO1999021855A1 (en) * 1997-10-29 1999-05-06 Smithkline Beecham P.L.C. Pleuromutilin derivatives as antimicrobials
WO2000007974A1 (en) * 1998-08-05 2000-02-17 Smithkline Beecham P.L.C. 2-fluoro mutilin derivatives
WO2000037074A1 (en) * 1998-12-18 2000-06-29 Smithkline Beecham Plc Mutilin 14-ester derivatives having antibacterial activity
WO2002030929A1 (en) * 2000-10-10 2002-04-18 Smithkline Beecham P.L.C. Novel pleuromutilin derivatives
WO2002038528A1 (en) * 2000-11-11 2002-05-16 Smithkline Beecham P.L.C. Pleuromutilin derivatives with antimicrobial activity
WO2007037518A1 (ja) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. ムチリン誘導体及びそれを含有する医薬組成物

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2011125684A1 (ja) * 2010-03-31 2013-07-08 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、重合体及び化合物
WO2011125684A1 (ja) * 2010-03-31 2011-10-13 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、重合体及び化合物
US10111875B2 (en) 2010-08-20 2018-10-30 Hutchinson Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
CN102372717A (zh) * 2010-08-20 2012-03-14 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
CN102372717B (zh) * 2010-08-20 2014-06-18 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
US10369153B2 (en) 2010-08-20 2019-08-06 Hutchison Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
US8182842B1 (en) 2010-11-10 2012-05-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Physico-chemical-managed killing of penicillin-resistant static and growing gram-positive and gram-negative vegetative bacteria
US9585886B2 (en) 2010-12-16 2017-03-07 Calchan Limited ASK1 inhibiting pyrrolopyrimidine derivatives
CN102924390A (zh) * 2012-09-07 2013-02-13 苏州康润医药有限公司 1,5-二氮杂环辛烷-1-甲酸叔丁酯的合成方法
CN102924390B (zh) * 2012-09-07 2014-12-31 苏州康润医药有限公司 1,5-二氮杂环辛烷-1-甲酸叔丁酯的合成方法
CN103265442A (zh) * 2013-06-05 2013-08-28 北京理工大学 一类新型截短侧耳素衍生物及其制备方法和抗肿瘤用途
CN103265442B (zh) * 2013-06-05 2017-02-08 北京理工大学 一类新型截短侧耳素衍生物及其制备方法和抗肿瘤用途
US9701628B2 (en) 2014-01-22 2017-07-11 Nabriva Therapeutics Ag 12-epi pleuromutilins
US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
US10399980B2 (en) 2015-11-20 2019-09-03 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
US11161848B2 (en) 2015-11-20 2021-11-02 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
US12043623B2 (en) 2015-11-20 2024-07-23 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
CN109195608A (zh) * 2016-03-02 2019-01-11 比尔及梅琳达盖茨基金会 含硼小分子
CN108484424A (zh) * 2018-04-08 2018-09-04 中国农业科学院兰州畜牧与兽药研究所 侧链含有季铵盐基团的截短侧耳素类衍生物及其用途
CN110467603A (zh) * 2019-07-08 2019-11-19 华南农业大学 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用
CN110467603B (zh) * 2019-07-08 2021-05-11 华南农业大学 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用
CN111793044A (zh) * 2020-07-21 2020-10-20 西华大学 哌嗪脲截短侧耳素衍生物及其用途
CN111793044B (zh) * 2020-07-21 2022-05-10 西华大学 哌嗪脲截短侧耳素衍生物及其用途

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