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WO2008114372A1 - 生体用蛍光測定装置及び蛍光測定用励起光照射装置 - Google Patents

生体用蛍光測定装置及び蛍光測定用励起光照射装置 Download PDF

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Publication number
WO2008114372A1
WO2008114372A1 PCT/JP2007/055470 JP2007055470W WO2008114372A1 WO 2008114372 A1 WO2008114372 A1 WO 2008114372A1 JP 2007055470 W JP2007055470 W JP 2007055470W WO 2008114372 A1 WO2008114372 A1 WO 2008114372A1
Authority
WO
WIPO (PCT)
Prior art keywords
exciting light
living body
fluorescent measurement
fluorescent
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/055470
Other languages
English (en)
French (fr)
Inventor
Ichiro Oda
Shinji Nagamachi
Kentaro Hizume
Yoshio Tsunazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to JP2009504972A priority Critical patent/JP4952784B2/ja
Priority to US12/531,903 priority patent/US8304746B2/en
Priority to PCT/JP2007/055470 priority patent/WO2008114372A1/ja
Publication of WO2008114372A1 publication Critical patent/WO2008114372A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

　漏れ光波長成分が少なく、かつ波長と照射方向が容易に切り替えられるようにするために、生体試料が載置される試料ホルダーと、レーザダイオード又は発光ダイオードからなり互いに異なる位置に配置された複数の励起光源、及び励起光源ごとに設けられて各励起光源スペクトル中検出蛍光の波長成分と重なる妨害波長成分を除去する光学特性をもつフィルタを備えた励起光照射装置と、励起光源の点灯を切り替えるための電気的スイッチと、試料ホルダー上の試料から放出される蛍光の像を撮影する検出器と、検出器が撮影した画像を表示する画像表示装置とを備えている。
PCT/JP2007/055470 2007-03-19 2007-03-19 生体用蛍光測定装置及び蛍光測定用励起光照射装置 Ceased WO2008114372A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009504972A JP4952784B2 (ja) 2007-03-19 2007-03-19 生体用蛍光測定装置及び蛍光測定用励起光照射装置
US12/531,903 US8304746B2 (en) 2007-03-19 2007-03-19 Fluorescent measurement device for living body and exciting light-irradiating device for fluorescent measurement
PCT/JP2007/055470 WO2008114372A1 (ja) 2007-03-19 2007-03-19 生体用蛍光測定装置及び蛍光測定用励起光照射装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/055470 WO2008114372A1 (ja) 2007-03-19 2007-03-19 生体用蛍光測定装置及び蛍光測定用励起光照射装置

Publications (1)

Publication Number Publication Date
WO2008114372A1 true WO2008114372A1 (ja) 2008-09-25

Family

ID=39765494

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/055470 Ceased WO2008114372A1 (ja) 2007-03-19 2007-03-19 生体用蛍光測定装置及び蛍光測定用励起光照射装置

Country Status (3)

Country Link
US (1) US8304746B2 (ja)
JP (1) JP4952784B2 (ja)
WO (1) WO2008114372A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010073917A1 (ja) * 2008-12-25 2010-07-01 株式会社日立ハイテクノロジーズ 分析装置
JP2017138329A (ja) * 2017-04-07 2017-08-10 株式会社島津製作所 光イメージング装置
CN115963091A (zh) * 2021-10-08 2023-04-14 由田新技股份有限公司 光学系统及荧光检测系统

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014115151A (ja) * 2012-12-07 2014-06-26 Shimadzu Corp 光イメージング装置
US8785885B1 (en) * 2013-01-30 2014-07-22 Omnivision Technologies, Inc. Fluorescence imaging module
DE102013111368A1 (de) * 2013-10-15 2015-04-16 Karl Storz Gmbh & Co. Kg Endoskopische, exoskopische oder mikroskopische Vorrichtung zur Fluoreszenzdiagnose
SE537103C2 (sv) 2013-12-16 2015-01-07 Per Fogelstrand System och metod för fluorescensmikroskopi med detektering av ljusemission från multipla fluorokromer
WO2015099347A1 (ko) * 2013-12-27 2015-07-02 주식회사 뷰웍스 동물용 영상장치
CN104807792B (zh) * 2015-04-27 2017-06-30 电子科技大学 一种负折射率光子晶体型生物荧光探测器
EP3159676B1 (de) * 2015-10-23 2018-04-04 Abberior Instruments GmbH Verfahren und vorrichtung zum hochauflösenden abbilden einer mit fluoreszenzmarkern markierten struktur einer probe
CN107478626A (zh) * 2017-08-24 2017-12-15 北京为肯科技有限公司 开放式荧光检测方法及设备
EP3986121A4 (en) * 2019-06-20 2023-07-05 The Trustees of the University of Pennsylvania SYSTEMS AND METHODS FOR AUTOMATED SMALL ANIMAL IMAGING AND HANDLING
WO2021237131A1 (en) * 2020-05-21 2021-11-25 University Of Miami Dosimetry system for photodynamic antimicrobial therapy device of infectious keratitis
CN114018814A (zh) * 2021-11-26 2022-02-08 上海仪电分析仪器有限公司 一种适用于荧光分光光度计的嵌入式组合激发光源
CN114486823A (zh) * 2021-12-24 2022-05-13 广东唯实生物技术有限公司 用于侧向免疫层析仪器的光路系统和手持设备
US20240138367A1 (en) * 2022-10-27 2024-05-02 Duke University System and method for three-dimensional kinematic profiling of animal models

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11326210A (ja) * 1998-05-14 1999-11-26 Nec Corp クロロフィル蛍光計測装置
JP2001154103A (ja) * 1999-11-30 2001-06-08 Mitsutoyo Corp 光学器械の照明装置
JP2003232736A (ja) * 2002-01-18 2003-08-22 Siemens Ag 光学的像形成方法および光学的像形成装置
JP2004532969A (ja) * 2000-10-12 2004-10-28 アムニス コーポレイション レポーターラベルビードを読み取るための方法および装置
JP2004325174A (ja) * 2003-04-23 2004-11-18 Olympus Corp 蛍光検出装置
JP2005172614A (ja) * 2003-12-11 2005-06-30 Satake Corp 穀類の品質評価装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7348587B2 (en) * 2001-06-28 2008-03-25 Fujifilm Corporation Method for producing biochemical analysis data and apparatus used therefor
US6894289B2 (en) 2002-02-22 2005-05-17 Xenogen Corporation Fluorescence illumination assembly for an imaging apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11326210A (ja) * 1998-05-14 1999-11-26 Nec Corp クロロフィル蛍光計測装置
JP2001154103A (ja) * 1999-11-30 2001-06-08 Mitsutoyo Corp 光学器械の照明装置
JP2004532969A (ja) * 2000-10-12 2004-10-28 アムニス コーポレイション レポーターラベルビードを読み取るための方法および装置
JP2003232736A (ja) * 2002-01-18 2003-08-22 Siemens Ag 光学的像形成方法および光学的像形成装置
JP2004325174A (ja) * 2003-04-23 2004-11-18 Olympus Corp 蛍光検出装置
JP2005172614A (ja) * 2003-12-11 2005-06-30 Satake Corp 穀類の品質評価装置

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010073917A1 (ja) * 2008-12-25 2010-07-01 株式会社日立ハイテクノロジーズ 分析装置
JP2010151665A (ja) * 2008-12-25 2010-07-08 Hitachi High-Technologies Corp 分析装置
US8895296B2 (en) 2008-12-25 2014-11-25 Hitachi High-Technologies Corporation Analyzer
US9523114B2 (en) 2008-12-25 2016-12-20 Hitachi High-Technologies Corporation Analyzer
JP2017138329A (ja) * 2017-04-07 2017-08-10 株式会社島津製作所 光イメージング装置
CN115963091A (zh) * 2021-10-08 2023-04-14 由田新技股份有限公司 光学系统及荧光检测系统

Also Published As

Publication number Publication date
US20100294947A1 (en) 2010-11-25
JPWO2008114372A1 (ja) 2010-07-01
US8304746B2 (en) 2012-11-06
JP4952784B2 (ja) 2012-06-13

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