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WO2008113112A1 - Structure d'arrêt pour dispositif microfluidique - Google Patents

Structure d'arrêt pour dispositif microfluidique Download PDF

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Publication number
WO2008113112A1
WO2008113112A1 PCT/AU2008/000368 AU2008000368W WO2008113112A1 WO 2008113112 A1 WO2008113112 A1 WO 2008113112A1 AU 2008000368 W AU2008000368 W AU 2008000368W WO 2008113112 A1 WO2008113112 A1 WO 2008113112A1
Authority
WO
WIPO (PCT)
Prior art keywords
passage
microchannel
fluid
stop
stop structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2008/000368
Other languages
English (en)
Inventor
Cedric Emile Francois Robillot
Klaus Stefan Drese
Dalibor Dadic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cleveland Biosensors Pty Ltd
Original Assignee
Cleveland Biosensors Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007901390A external-priority patent/AU2007901390A0/en
Application filed by Cleveland Biosensors Pty Ltd filed Critical Cleveland Biosensors Pty Ltd
Publication of WO2008113112A1 publication Critical patent/WO2008113112A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0017—Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0057—Operating means specially adapted for microvalves actuated by fluids the fluid being the circulating fluid itself, e.g. check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0078—Fabrication methods specifically adapted for microvalves using moulding or stamping

Definitions

  • This invention relates to stop structures for microfluidic devices.
  • it relates to three dimensional stop structures.
  • a novel microfluidic device is described in our co-pending international patent application number PCT/AU2005/001341.
  • This device and other known microfluidic devices move fluids through microchannels.
  • the forces acting upon the moving fluids are complex and include capillary forces (i.e. wall/fluid interaction) as well as pressure, electrohydrodynamical and magnetic forces.
  • the driving force is provided by some form of pump such as a peristaltic pump, a ferrofluidic pump, electroosmotic pump, thermopneumatic pump or a diaphragm pump.
  • the driving force is generated locally, for example by a capillary driving force.
  • structures are required to help control the flow of fluid through the microchannels in addition to the control provided by the pump, if useful devices are to be constructed.
  • One form of device for flow control is a mechanical valve which commonly is in the form of a membrane, pin or ball.
  • These type of moving part structures can be problematic in microchannel devices as they typically have leak problems and introduce significant dead volumes. They also tend to fatigue with repeated use which leads to failure.
  • Typical physical flow control solutions include wax plugs, hydrogels, magneto-rheological fluids and electro-rheological fluids. This approach is problematic for microassay applications as the chemicals can cause contamination of the microassay. Furthermore, the performance of these solutions is usually microassay dependent, leading to non-robust solutions.
  • Flow control may also be affected by using chemical and/or physical modifications to change the local surface energy of a capillary.
  • These solutions are commonly referred to as passive valves.
  • a typical example is described in United States published patent application number 2002/0003001. This patent application describes the use of a hydrophobic coating to increase surface tension.
  • Chemical modifications can lead to unwanted binding of reagents which changes the assay. This is a very unwanted effect since handled volumes are small and unspecific binding is one of the largest challenges within the field of microfluidics.
  • physical changes generally lead to increased surface energy which leads to the same effects as occurs for the chemical modifications.
  • a second shortcoming of the surface energy solution is that the free surface energy density of the wall-fluid contact has a lower limit. For fluids with a low free surface energy density, no large contact angle will be formed. (The contact angles can be calculated via the Young-Laplace equation using the free surface energy densities of the solid-gas, gas-liquid and liquid-solid interaction. The gas can in principle be a second liquid.) Since no large contact angle can be formed, no passive chemical valve can be generated.
  • United States published patent application number 2004/0028566 includes a description of the effect of hydrophobic and hydrophilic materials on contact angle, which description is incorporated herein by reference.
  • the bioassay chip incorporates a number of passive stop structures allowing the containment of reagents in individual chambers.
  • a minimum cross-sectional dimension of the stop structure is sufficiently smaller than a minimum cross-sectional dimension of the second channel so that differential capillary forces prevent wicking of fluid from the first channel, through the stop structure, and into the second channel when there is no fluid in the second channel.
  • the invention resides in a stop structure for a microfluidic device comprising: a passage in fluid connection with a microchannel wherein at an intersection of the passage and the microchannel the passage widens in all directions orthogonal to the direction of the passage.
  • the change in dimension at the intersection between the passage and the microchannel is sufficient to promote formation of a meniscus of a fluid in the passage.
  • an angle between a wall of the passage and an adjoining wall of the microchannel is nominally at least 225 degrees.
  • the passage is suitably a hole.
  • the passage is a tube that extends beyond the surface of the microchannel.
  • the preferred shape of the passage is round but other shapes would also be suitable.
  • the invention resides in a method of manufacturing a stop structure in a microfluidic device including the steps of: forming a microchannel in a substrate; and forming a passage intersecting the microchannel wherein at an intersection of the passage and the microchannel the passage widens in all directions orthogonal to the direction of the passage.
  • the invention resides in a structure for control of movement of fluid in a microfluidic device comprising: a series of stop structures in fluid connection wherein each stop structure in the series comprises a passage providing fluid connection between a pair of microchannels, wherein at an intersection of the passage and at least one microchannel of the pair of microchannels the passage widens in all directions orthogonal to the direction of the passage, and wherein adjacent stop structures share a common microchannel.
  • the passages of the stop structures in the series are parallel to each other.
  • the passage may suitably be a hole formed between adjacent microchannels.
  • the passage may be a tube that extends beyond the surface at least one of the microchannels.
  • the invention resides in a method of manufacturing a structure for control of movement of fluid in a microfluidic device including the steps of: forming at least a first microchannel in one part of a substrate; forming at least a second microchannel in another part of the substrate; and forming a series of stop structures connecting the first and second microchannels, each stop structure comprising a passage intersecting an end of the first microchannel and an end of the second microchannel wherein at an intersection of the passage and the microchannel the passage widens in all directions orthogonal to the direction of the passage.
  • Fig 1 is a schematic of a first stop structure in a series of stop structures according to a first embodiment of the invention showing a cross-sectional side view (1a), a cross-sectional end view (1b) and a plan view (1c);
  • Fig 2 shows the stop structure of Fig 1 with a fluid;
  • Fig 3 is a schematic of a stop structure according to a second embodiment of the invention.
  • Fig 4 is a schematic of a stop structure according to a third embodiment of the invention.
  • Fig 5 shows the stop structure of Fig 4 with a fluid;
  • Fig 6 is a schematic of a stop structure according to a fourth embodiment of the invention.
  • Fig 7 shows the stop structure of Fig 6 with a fluid
  • Fig 8 is a perspective view of a structure for control of movement of fluid in a microfluidic device comprising a series of three stop structures according to a fifth embodiment of the invention.
  • Fig 9 shows a side view of the stop structure of Fig 8.
  • Fig 1 there is shown a structure for control of movement of fluid in a microfluidic device.
  • the structure comprises a single stop structure in a microfluidic device 10 having a first microchannel 11 in fluid connection with a second microchannel 12 via a passage 13.
  • the microchannels 11, 12 are connected by the passage 13 that extends from the first microchannel 11 to the second microchannel 12.
  • Fig 1a shows a side elevation that indicates that the microchannels 11 , 12 continue to complete the microfluidic device.
  • the passage 13 and the second microchannel 12 form a stop structure when fluid flows from the first microchannel 11 to the second microchannel 12.
  • a stop structure is formed by the passage 13 and the first microchannel 11. The structure therefore provides for bi-directional control of movement of fluid in the microfluidic device.
  • the first microchannel 11 is formed on one side of the microfluidic device 10 and the second microchannel 12 is formed on the other side.
  • the passage 13 therefore is constructed to pass through the microfluidic device 10.
  • microchannels 11 , 12 extend beyond the intersection with, and are wider than, the passage 13 so that a nominally 270 degree corner is formed all around the passage 13.
  • These structures constitute sharp edges that promote surface tension within fluid 20 that flows through continuing microchannel 11 and into the passage 13.
  • the large angle between all walls of the passage 13 and walls of the microchannel 12 means that creep of the fluid along the wall is virtually eliminated. This is contrasted with prior art structures which are essentially two dimensional and allow fluid creep along the "floor" and "ce ' ling" of the passive stop structure.
  • the corner may nominally be 225 degree or greater but may vary from this value by several degrees.
  • the angle between the wall of the microchannel 12 and the wall of the passage 13 at the intersection is nominally 270 degree if the passage 12 is created by drilling through the microchannel with an angle that is normal to the wall surface of the microchannel 12.
  • FIG 1 the passage 13 widens in all directions orthogonal to the direction of the passage 13 at microchannel 12 (or in the reverse direction, microchannel 11). It will be appreciated by persons skilled in the art that a problem with the 2D structures of the prior art is that there is always at least one continuous wall between the microchannel and the passage so that fluid creeps along the wall and the stop structure fails. In contrast the adjoining walls between the passage 13 and the microchannels 11, 12 are discontinuous and therefore wall creep is virtually eliminated or at least significantly reduced.
  • Fig 3 shows a second embodiment incorporating two adjacent stop structures in a series. The embodiment of Fig 3 adds effective stop structures to conventional microfluidic device designs. A portion of a microfluidic device 30 has a first microchannel 31 that extends to other parts of the device 30.
  • a first passage 32 is formed to extend from the continuing microchannel 31 to a connecting microchannel 33 and a second passage 34 reconnects the connecting microchannel 33 with the continuing microchannel 31.
  • the incorporation of an even number of stop structures provides a high degree of control of the movement of fluid through microfluidic device 30. This is because even if one stop structure in a pair of stop structures fails to control the movement of fluid, another subsequent stop structure in the pair can control the movement of fluid. For example, even if the first stop structure 35 fails to control the movement of fluid, the second stop structure 36 can control the movement of fluid.
  • Microfluidic devices such as those depicted in our co-pending application, are typically produced by forming open microchannels in a surface of a substrate and bonding a cover to the substrate to close the microchannels.
  • microchannels of odd numbered stop structures in the series are all conveniently formed in the same side of the microfluidic device and microchannels of even numbered stop structures in the series are conveniently formed in the other side of the microfluidic device.
  • a first stop structure and a third stop structure in a series are on the same side of the microfluidic device, whereas a second stop structure in the series and a fourth stop structure in the series are on the same other side of the microfluidic device.
  • the microfluidic device 30 can be constructed by forming microchannels in both sides of a substrate. As discussed above, microchannels 33 are all formed in the same one side of the microfluidic device and microchannels 31 are all formed in the same another side of the microfluidic device.
  • the connecting passages 32, 34 may be, for example, drilled between microchannels 31, 33.
  • Covers 37, 38 are bonded to the top and bottom surfaces of the substrate to complete the microfluidic device.
  • a designer of a microfluidic device suitably is able to construct a fluid pattern of continuing microchannels in the same plane and introduce a pair of stop structures at any point of the continuing microchannels to provide a robust control of the movement of fluid.
  • a pair of stop structures is more robust than one stop structure because of a fail safe feature of a control structure comprising a series of stop structures.
  • microfluidic device having all continuing microchannels in the same one side of a substrate of the microfluidic device and having connecting microchannels in the same other side of the substrate.
  • design of mould inserts for injection moulding can be rationalized and simplified. In many cases an even number of stop structures in the series will be preferable from a manufacturing perspective but there is no inherent limitation on the number of stop structures in the series.
  • all connecting microchannels are similar in length.
  • all connecting microchannels 33 in the microfluidic device 30 can have the same length, whereas the continuing microchannels can have different arbitrary lengths. As discussed above, this can simplify both design and manufacturing processes. It also assists manufacturing if passages in the series are parallel.
  • Fig 4 It is known that many fluids exhibit wall creep and do not easily form a meniscus. The embodiment shown in Fig 4 is particularly useful for such situations.
  • the stop structure of Fig 4 is similar to the stop structures described above except that the passage extends beyond the microchannel.
  • a first microchannel 41 is in fluid connection with a second microchannel 42.
  • the microchannels 41 , 42 are connected by a passage 43 that extends from the first microchannel 41 to the second microchannel 42.
  • the passage 43 extends beyond the surface of the second microchannel 42 and forms an apron 44.
  • the angle between the surface of the apron 44 and the wall of the passage 43 at the intersection is greater than 270 degrees and therefore promotes the formation of a meniscus 51 in fluid 50, as shown in Fig 5.
  • An even greater contact angle is achieved by the embodiment shown in Fig 6.
  • a first microchannel 61 is in fluid connection with a second microchannel 62.
  • the microchannels 61, 62 are connected by a tube 63 that extends from the first microchannel 61 to the second microchannel 62.
  • the passage 63 extends beyond the surface of the second microchannel 62 and forms a stub 64 that extends into the second microchannel 62.
  • the angle between the top of the stub 64 and the wall of the second microchannel 62 is much greater than 270 degrees and therefore promotes the formation of a meniscus 71 in fluid 70, as shown in Fig 7.
  • the structures depicted above can be constructed in a variety of ways.
  • microfluidic devices involves the etching of channels in a substrate followed by sealing of the channels by bonding a cover slip to the substrate.
  • Each of the embodiments can be constructed by injection moulding with the passages formed by pins placed through the mould. Other manufacturing techniques can be applied. For example, a step of through-hole drilling or laser ablation during manufacture is the only additional step required for construction of the first and second embodiments.
  • the third embodiment can involve a modified etching process to form the apron 44.
  • the fourth embodiment can involve a bonding step to bond a tube 63 into a hole formed in the manner used for the first and second embodiments.
  • FIG 8 shows an example of a structure for control of movement of fluid that incorporates three stop structures. This embodiment demonstrates that the invention is not limited to an even number of stop structures.
  • microchannels 82 are formed in a conventional manner with passages
  • microchannels 82 formed between the microchannels 82.
  • One approach is to injection mould the substrate 80 with pins positioned to form the passages 81. The pins are removed and the apertures 83 are sealed with epoxy plug 84 (shown in FIG 9).
  • the microchannels 82 may then be etched into the substrate 80 in conventional manner and a cover slip 85 used to seal the microchannels. As can be seen in the cross-section view of FIG 9, a stop structure is formed at each intersection of the microchannel 82 and the passage 81.
  • stop structures have been described in terms of a passage between a pair of microchannels, it will be appreciated that this is not essential.
  • the primary requirement is an intersection of a passage and one microchannel.
  • the other end of the passage may be in fluid connection with a buffer chamber or other microfluidic structure.
  • a stop structure is used to control movement of fluid 100 from buffer chamber 101 to microchannel 103 through passage 103, forming a meniscus 104.
  • the stop structures are used in the microfluidic device to control the movement of fluids through the device.
  • the fluids may be reagents, detergents, buffers or any of many fluids that are used in microfluidic assay devices.

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)

Abstract

L'invention porte sur une structure d'arrêt permettant de contrôler les déplacements d'un fluide dans un dispositif microfluidique et formant un ménisque à l'intersection d'un passage et d'un micro-canal dans le dispositif microfluidique. Le passage s'agrandit dans toutes les directions orthogonales à la direction dudit passage, formant ainsi un angle large de 225 degrés au moins entre une paroi du passage et une paroi adjacente du micro-canal.
PCT/AU2008/000368 2007-03-16 2008-03-14 Structure d'arrêt pour dispositif microfluidique Ceased WO2008113112A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2007901390A AU2007901390A0 (en) 2007-03-16 Stop structure for microfluidic device
AU2007901390 2007-03-16
AU2007905454 2007-10-05
AU2007905454A AU2007905454A0 (en) 2007-10-05 Stop structure for microfluidic device

Publications (1)

Publication Number Publication Date
WO2008113112A1 true WO2008113112A1 (fr) 2008-09-25

Family

ID=39765281

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2008/000368 Ceased WO2008113112A1 (fr) 2007-03-16 2008-03-14 Structure d'arrêt pour dispositif microfluidique

Country Status (1)

Country Link
WO (1) WO2008113112A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011156855A1 (fr) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Dispositif microfluidique dans lequel les proportions de mélange de réactif sont déterminées par le nombre de soupapes d'évacuation actives
WO2019240764A1 (fr) * 2018-06-11 2019-12-19 Hewlett-Packard Development Company, L.P. Vannes microfluidiques

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1441131A1 (fr) * 2003-01-23 2004-07-28 Steag MicroParts GmbH Commutateur microfluidique pour arrêter temporairement un courant de liquide
US20040231736A1 (en) * 2003-05-22 2004-11-25 Kim Sung Jin Micro fluidic device for controlling flow time of micro fluid
EP1520838A1 (fr) * 2003-09-30 2005-04-06 Boehringer Ingelheim microParts GmbH Methode et dispositv pour coupler des fibres vides à un reseau microfluidique.
EP1525917A1 (fr) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Dispositif microfluidique avec traversée
EP1525916A1 (fr) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Dispositif de déclenchement d'écoulement
US20050133101A1 (en) * 2003-12-22 2005-06-23 Chung Kwang H. Microfluidic control device and method for controlling microfluid
US20060280653A1 (en) * 2005-06-13 2006-12-14 Harding Philip H Microfluidic centrifugation systems
WO2007093712A1 (fr) * 2006-02-16 2007-08-23 Commissariat A L'energie Atomique Procede de controle de l'avancee d'un liquide dans un composant microfluidique

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1441131A1 (fr) * 2003-01-23 2004-07-28 Steag MicroParts GmbH Commutateur microfluidique pour arrêter temporairement un courant de liquide
US20040231736A1 (en) * 2003-05-22 2004-11-25 Kim Sung Jin Micro fluidic device for controlling flow time of micro fluid
EP1520838A1 (fr) * 2003-09-30 2005-04-06 Boehringer Ingelheim microParts GmbH Methode et dispositv pour coupler des fibres vides à un reseau microfluidique.
EP1525917A1 (fr) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Dispositif microfluidique avec traversée
EP1525916A1 (fr) * 2003-10-23 2005-04-27 F. Hoffmann-La Roche Ag Dispositif de déclenchement d'écoulement
US20050133101A1 (en) * 2003-12-22 2005-06-23 Chung Kwang H. Microfluidic control device and method for controlling microfluid
US20060280653A1 (en) * 2005-06-13 2006-12-14 Harding Philip H Microfluidic centrifugation systems
WO2007093712A1 (fr) * 2006-02-16 2007-08-23 Commissariat A L'energie Atomique Procede de controle de l'avancee d'un liquide dans un composant microfluidique

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011156855A1 (fr) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Dispositif microfluidique dans lequel les proportions de mélange de réactif sont déterminées par le nombre de soupapes d'évacuation actives
WO2011156848A1 (fr) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Dispositif microfluidique présentant une structure à canaux d'écoulement comportant un clapet actif pour propulsion fluidique par capillarité sans bulles d'air piégées
WO2019240764A1 (fr) * 2018-06-11 2019-12-19 Hewlett-Packard Development Company, L.P. Vannes microfluidiques
EP3758844A4 (fr) * 2018-06-11 2021-03-03 Hewlett-Packard Development Company, L.P. Vannes microfluidiques
US20210170408A1 (en) * 2018-06-11 2021-06-10 Hewlett-Packard Development Company, L.P. Microfluidic valves
US12220701B2 (en) * 2018-06-11 2025-02-11 Hewlett-Packard Development Company, L.P. Microfluidic valves

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