[go: up one dir, main page]

WO2008110351A3 - Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents - Google Patents

Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents Download PDF

Info

Publication number
WO2008110351A3
WO2008110351A3 PCT/EP2008/001965 EP2008001965W WO2008110351A3 WO 2008110351 A3 WO2008110351 A3 WO 2008110351A3 EP 2008001965 W EP2008001965 W EP 2008001965W WO 2008110351 A3 WO2008110351 A3 WO 2008110351A3
Authority
WO
WIPO (PCT)
Prior art keywords
epidermal
present
aryl
infections
antiseptic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/001965
Other languages
French (fr)
Other versions
WO2008110351A2 (en
Inventor
Marco Cantarini
Marco Gentile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe SpA
Original Assignee
Dompe PhaRMa SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe PhaRMa SpA filed Critical Dompe PhaRMa SpA
Publication of WO2008110351A2 publication Critical patent/WO2008110351A2/en
Publication of WO2008110351A3 publication Critical patent/WO2008110351A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to the use of amides of (R) and (S)-2-aryl- propionic acids as antiseptic agents. The present invention also provides a pharmaceutical preparation including compounds of formula (I), having antiseptic properties for the treatment of gastrointestinal, muco-epidermal and epidermal infections. The present invention is related to pharmaceutical compositions containing an antiseptic agent carried in a suitable vehicle to provide mouthwashes, tablets, solutions, gels, creams and others. The formulations are applied topically to sites of gastrointestinal, muco-epidermal or epidermal infections. Compounds of present invention can be useful in the treatment of nausea, vomiting, bloating, diarrhea, constipation and oropharyngeal, esophageal, vaginal, rectal, nasal and other mucosal infections.
PCT/EP2008/001965 2007-03-15 2008-03-12 Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents Ceased WO2008110351A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07104237.8 2007-03-15
EP07104237 2007-03-15

Publications (2)

Publication Number Publication Date
WO2008110351A2 WO2008110351A2 (en) 2008-09-18
WO2008110351A3 true WO2008110351A3 (en) 2009-04-30

Family

ID=39760135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/001965 Ceased WO2008110351A2 (en) 2007-03-15 2008-03-12 Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents

Country Status (1)

Country Link
WO (1) WO2008110351A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX379054B (en) * 2008-12-04 2025-03-11 Chongxi Yu HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS.
CN103030574B (en) * 2013-01-04 2014-10-01 中国农业大学 A class of cyanoamide-containing compounds and their synthesis method and application

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942600A (en) * 1995-05-25 1999-08-24 G. D. Searle & Co. Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents
WO2001062709A2 (en) * 2000-02-24 2001-08-30 Jomaa Pharmaka Gmbh Use of 2-phenylene diamine derivatives for the treatment of infections
WO2001087838A1 (en) * 2000-05-19 2001-11-22 Merck Sharp & Dohme Limited Cyclohexane derivatives and their use as therapeutic agents
WO2002059081A2 (en) * 2001-01-26 2002-08-01 Kirin Beer Kabushiki Kaisha Urea derivatives as inhibitors of ccr-3 receptor
WO2002065977A2 (en) * 2001-02-20 2002-08-29 Israel Institute For Biological Research Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof
WO2002068377A1 (en) * 2001-02-27 2002-09-06 Dompé S.p.A. Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity
WO2005110970A1 (en) * 2004-05-10 2005-11-24 Grünenthal GmbH Oxo-substituted cyclohexyl-1,4-diamine derivatives
WO2007045462A2 (en) * 2005-10-19 2007-04-26 Grünenthal GmbH Novel vanilloid receptor ligands and their use for producing medicaments
WO2008010025A1 (en) * 2006-07-18 2008-01-24 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
WO2008012605A1 (en) * 2006-07-27 2008-01-31 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate
WO2008125337A2 (en) * 2007-04-16 2008-10-23 Grünenthal GmbH Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942600A (en) * 1995-05-25 1999-08-24 G. D. Searle & Co. Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents
WO2001062709A2 (en) * 2000-02-24 2001-08-30 Jomaa Pharmaka Gmbh Use of 2-phenylene diamine derivatives for the treatment of infections
WO2001087838A1 (en) * 2000-05-19 2001-11-22 Merck Sharp & Dohme Limited Cyclohexane derivatives and their use as therapeutic agents
WO2002059081A2 (en) * 2001-01-26 2002-08-01 Kirin Beer Kabushiki Kaisha Urea derivatives as inhibitors of ccr-3 receptor
WO2002065977A2 (en) * 2001-02-20 2002-08-29 Israel Institute For Biological Research Compounds co-inducing cholinergic up-regulation and inflammation down-regulation and uses thereof
WO2002068377A1 (en) * 2001-02-27 2002-09-06 Dompé S.p.A. Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity
WO2005110970A1 (en) * 2004-05-10 2005-11-24 Grünenthal GmbH Oxo-substituted cyclohexyl-1,4-diamine derivatives
WO2007045462A2 (en) * 2005-10-19 2007-04-26 Grünenthal GmbH Novel vanilloid receptor ligands and their use for producing medicaments
WO2008010025A1 (en) * 2006-07-18 2008-01-24 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
WO2008012605A1 (en) * 2006-07-27 2008-01-31 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate
WO2008125337A2 (en) * 2007-04-16 2008-10-23 Grünenthal GmbH Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALLEGRETTI M ET AL: "2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 48, no. 13, 30 June 2005 (2005-06-30), pages 4312 - 4331, XP008102465, ISSN: 0022-2623, [retrieved on 20050527] *
AURELI L ET AL: "Predicting human serum albumin affinity of Interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON.; US, vol. 48, 8 March 2005 (2005-03-08), pages 2469 - 2479, XP002380701, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2008110351A2 (en) 2008-09-18

Similar Documents

Publication Publication Date Title
WO2008046758A3 (en) Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes
CA2696335A1 (en) Gel containing pirfenidone
WO2009150137A3 (en) Pyrazine derivatives as epithelial sodium channel blockers
WO2009129545A8 (en) Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
WO2001019780A3 (en) Novel derivatives of dicarboxylic acid having pharmaceutical properties
CA2453243A1 (en) Treatment of nail infections with no
WO2001019776A3 (en) Novel derivatives of dicarboxylic acid having pharmaceutical properties
WO2010032147A3 (en) Hydroxamic acid derivatives useful as antibacterial agents
CY1112276T1 (en) PRODUCTS (3-AMINO-1,2,3,4-tetrahydro-9H-CARVASOL-9-YL) - ACIC ACID
WO2010084115A3 (en) Antiviral agents
WO2005005389A3 (en) Malonamide derivatives
WO2008074824A3 (en) Isoquinolinecarboxamides as inhibitors of stearoyl-coa desaturase (scd)
WO2007099553A3 (en) 1,3-dioxane carboxylic acids
WO2004100865A3 (en) New benzimidazole derivatives
WO2011025982A3 (en) Tetracycline compounds
WO2005040171A8 (en) Pyrazolo and imidazo-pyrimidine derivatives
WO2008042944A3 (en) Non-irritating oral care formulations
WO2011047055A3 (en) Novel mek inhibitors, useful in the treatment of diseases
ITMI20070644A1 (en) TOPIC COMPOSITIONS INCLUDING MAGALDRATE
MX2009002435A (en) Medicine for the treatment of acne and for reversing the signs of age and sun damage and method for using same.
WO2006100225A3 (en) Benzoic acid ester compounds, compositions, uses and methods related thereto
WO2007110834A3 (en) Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
MY149181A (en) Isoxazoline derivative and preparation process thereof
WO2008110351A3 (en) Use of (r) and (s)-2-aryl-propionic acid derivatives as antiseptic agents
JP3510591B2 (en) Polyethoxylated retinamide derivative and method for producing the same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08716470

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08716470

Country of ref document: EP

Kind code of ref document: A2