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WO2008108324A1 - ベシクルの製造方法、この製造方法によって得られるベシクル、ベシクルの製造に用いられる凍結粒子の製造方法 - Google Patents

ベシクルの製造方法、この製造方法によって得られるベシクル、ベシクルの製造に用いられる凍結粒子の製造方法 Download PDF

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Publication number
WO2008108324A1
WO2008108324A1 PCT/JP2008/053740 JP2008053740W WO2008108324A1 WO 2008108324 A1 WO2008108324 A1 WO 2008108324A1 JP 2008053740 W JP2008053740 W JP 2008053740W WO 2008108324 A1 WO2008108324 A1 WO 2008108324A1
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WO
WIPO (PCT)
Prior art keywords
vesicle
producing
oil phase
frozen particles
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053740
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English (en)
French (fr)
Inventor
Sosaku Ichikawa
Takashi Kuroiwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tsukuba NUC
Original Assignee
University of Tsukuba NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tsukuba NUC filed Critical University of Tsukuba NUC
Priority to EP08721160.3A priority Critical patent/EP2116297A4/en
Priority to US12/449,882 priority patent/US8246868B2/en
Publication of WO2008108324A1 publication Critical patent/WO2008108324A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

【課題】　粒径など所望の物性を制御しつつ、所望の物質の高い内包率が達成できるベシクルの製造方法を提供する。 【解決手段】　内包させる物質を溶解あるいは懸濁状態で含む水溶液と、乳化剤を含む油相とからＷ/Ｏエマルションを作成し、次いで、前記Ｗ/Ｏエマルションの水溶液が凍結粒子となり油相は液体の状態を維持する温度まで冷却して油相を除去し、この後、前記凍結粒子にベシクル構成脂質を含む油相を添加し、攪拌することで凍結粒子表面の乳化剤をベシクル構成脂質に置換し、そして、脂質膜によって表面が覆われた凍結粒子に外水相を添加し、外水相と脂質膜とを水和させる。
PCT/JP2008/053740 2007-03-02 2008-03-03 ベシクルの製造方法、この製造方法によって得られるベシクル、ベシクルの製造に用いられる凍結粒子の製造方法 Ceased WO2008108324A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08721160.3A EP2116297A4 (en) 2007-03-02 2008-03-03 METHOD FOR THE PRODUCTION OF VESICLES, VESICLES OBTAINED BY THE METHOD, AND METHOD FOR THE PRODUCTION OF FROZEN PARTICLES FOR USE IN VESICLE MANUFACTURE
US12/449,882 US8246868B2 (en) 2007-03-02 2008-03-03 Method for producing vesicle, vesicle obtained by the production method, and method for producing frozen particle used in production of vesicle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-053089 2007-03-02
JP2007053089A JP4009733B1 (ja) 2007-03-02 2007-03-02 ベシクルの製造方法、この製造方法によって得られるベシクル、ベシクルの製造に用いられる凍結粒子の製造方法

Publications (1)

Publication Number Publication Date
WO2008108324A1 true WO2008108324A1 (ja) 2008-09-12

Family

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PCT/JP2008/053740 Ceased WO2008108324A1 (ja) 2007-03-02 2008-03-03 ベシクルの製造方法、この製造方法によって得られるベシクル、ベシクルの製造に用いられる凍結粒子の製造方法

Country Status (4)

Country Link
US (1) US8246868B2 (ja)
EP (1) EP2116297A4 (ja)
JP (1) JP4009733B1 (ja)
WO (1) WO2008108324A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009271294A (ja) * 2008-05-07 2009-11-19 Ricoh Co Ltd 感光体用保護剤、及び保護層形成装置、並びに画像形成装置
JP2009280525A (ja) * 2008-05-23 2009-12-03 Univ Of Tsukuba ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのｗ／ｏ／ｗエマルション
WO2011001780A1 (ja) * 2009-07-02 2011-01-06 コニカミノルタホールディングス株式会社 特定分散剤を含有する外水相を利用する二段階乳化法によるリポソームの製造方法、ならびに当該リポソームの製造方法を用いるリポソーム分散液またはその乾燥粉末の製造方法およびそれにより製造されるリポソーム分散液またはその乾燥粉末
CN102871936A (zh) * 2012-11-05 2013-01-16 上海相宜本草化妆品股份有限公司 负载红景天提取物的纳米载体及其制备方法和用途

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2956594B1 (fr) * 2010-02-19 2012-04-27 Univ Claude Bernard Lyon Nouveau procede de preparation de liposomes, mettant en oeuvre un reacteur membranaire
CN102489230B (zh) * 2011-12-06 2015-08-19 中国科学院过程工程研究所 一种生物可降解聚合物微囊的制备方法
KR101933620B1 (ko) 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
KR101933622B1 (ko) 2012-10-09 2018-12-28 삼성전자주식회사 소포를 모니터링하기 위한 조성물, 키트 및 이를 이용하여 소포를 모니터링하는 방법
KR102522167B1 (ko) 2020-10-23 2023-04-14 포항공과대학교 산학협력단 인공 마이크로베시클 제조방법
JPWO2023048097A1 (ja) * 2021-09-21 2023-03-30

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WO2004026457A1 (ja) 2002-09-18 2004-04-01 Koyama, Yuu マイクロカプセルの製造方法
JP2008029952A (ja) * 2006-07-28 2008-02-14 National Institute Of Advanced Industrial & Technology ベシクルを利用した並列反応方法

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US6214375B1 (en) * 1996-07-16 2001-04-10 Generex Pharmaceuticals, Inc. Phospholipid formulations
WO2002058671A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Burst free pharmaceutical microparticules

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2004026457A1 (ja) 2002-09-18 2004-04-01 Koyama, Yuu マイクロカプセルの製造方法
JP2008029952A (ja) * 2006-07-28 2008-02-14 National Institute Of Advanced Industrial & Technology ベシクルを利用した並列反応方法

Non-Patent Citations (4)

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OKU ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 691, 1982, pages 332 - 340
See also references of EP2116297A4 *
SZOKA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 75, no. 9, 1978, pages 4194 - 4198
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009271294A (ja) * 2008-05-07 2009-11-19 Ricoh Co Ltd 感光体用保護剤、及び保護層形成装置、並びに画像形成装置
JP2009280525A (ja) * 2008-05-23 2009-12-03 Univ Of Tsukuba ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのｗ／ｏ／ｗエマルション
WO2011001780A1 (ja) * 2009-07-02 2011-01-06 コニカミノルタホールディングス株式会社 特定分散剤を含有する外水相を利用する二段階乳化法によるリポソームの製造方法、ならびに当該リポソームの製造方法を用いるリポソーム分散液またはその乾燥粉末の製造方法およびそれにより製造されるリポソーム分散液またはその乾燥粉末
JP4900536B2 (ja) * 2009-07-02 2012-03-21 コニカミノルタホールディングス株式会社 特定の分散剤を含有する外水相を利用する二段階乳化法による単胞リポソームの製造方法、ならびに当該単胞リポソームの製造方法を用いる単胞リポソーム分散液またはその乾燥粉末の製造方法
CN102871936A (zh) * 2012-11-05 2013-01-16 上海相宜本草化妆品股份有限公司 负载红景天提取物的纳米载体及其制备方法和用途

Also Published As

Publication number Publication date
JP2008212813A (ja) 2008-09-18
US8246868B2 (en) 2012-08-21
EP2116297A4 (en) 2014-11-05
US20100029791A1 (en) 2010-02-04
JP4009733B1 (ja) 2007-11-21
EP2116297A1 (en) 2009-11-11

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