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WO2008108155A1 - 抗シワ物質の評価法及び皮膚の鑑別法 - Google Patents

抗シワ物質の評価法及び皮膚の鑑別法 Download PDF

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Publication number
WO2008108155A1
WO2008108155A1 PCT/JP2008/052626 JP2008052626W WO2008108155A1 WO 2008108155 A1 WO2008108155 A1 WO 2008108155A1 JP 2008052626 W JP2008052626 W JP 2008052626W WO 2008108155 A1 WO2008108155 A1 WO 2008108155A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
substance
test substance
antiwrinkle
assessing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/052626
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English (en)
French (fr)
Inventor
Naoko Kida
Akihiro Tada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Orbis Holdings Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Priority to JP2009502500A priority Critical patent/JPWO2008108155A1/ja
Priority to US12/529,505 priority patent/US20100081162A1/en
Priority to TW097112806A priority patent/TW200942813A/zh
Publication of WO2008108155A1 publication Critical patent/WO2008108155A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cosmetics (AREA)

Abstract

　皮膚の弾力の消失、シワ形成可能性、真皮コラーゲン繊維束の結束不全等の皮膚の状態を、正確かつ簡易に鑑別する方法を提供することを課題とする。また、本発明は、被験物質のシワ改善作用正確かつ簡易に評価する方法を提供する。皮膚の細胞における接着因子の発現量を指標として、皮膚の状態を鑑別する。また、被験物質の存在下での、皮膚の細胞における接着因子の発現量を指標として、該被験物質のシワ改善作用を評価する。
PCT/JP2008/052626 2007-03-01 2008-02-18 抗シワ物質の評価法及び皮膚の鑑別法 Ceased WO2008108155A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009502500A JPWO2008108155A1 (ja) 2007-03-01 2008-02-18 抗シワ物質の評価法及び皮膚の鑑別法
US12/529,505 US20100081162A1 (en) 2007-03-01 2008-02-18 Method of evaluating antiwrinkle substance and method of assessing the skin
TW097112806A TW200942813A (en) 2007-03-01 2008-04-09 Method for evaluating anti-wrinkle substance and method for evaluating skin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-051025 2007-03-01
JP2007051025 2007-03-01

Publications (1)

Publication Number Publication Date
WO2008108155A1 true WO2008108155A1 (ja) 2008-09-12

Family

ID=39738052

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052626 Ceased WO2008108155A1 (ja) 2007-03-01 2008-02-18 抗シワ物質の評価法及び皮膚の鑑別法

Country Status (4)

Country Link
US (1) US20100081162A1 (ja)
JP (1) JPWO2008108155A1 (ja)
TW (1) TW200942813A (ja)
WO (1) WO2008108155A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011219454A (ja) * 2010-03-24 2011-11-04 Fancl Corp 細胞間接着剤
JP2016187324A (ja) * 2015-03-30 2016-11-04 ポーラ化成工業株式会社 タルミ改善剤のスクリーニング法
WO2019225728A1 (ja) * 2018-05-25 2019-11-28 ポーラ化成工業株式会社 加齢又は低酸素による皮膚の状態を改善する成分のスクリーニング方法並びに皮下組織の粘弾性を指標とする皮下組織の酸素レベル又は皮下脂肪細胞の線維化レベルの推定方法
JP2020051869A (ja) * 2018-09-26 2020-04-02 ポーラ化成工業株式会社 コラーゲン線維の結束度を指標とする、低酸素条件及び／又は加齢による、コラーゲン構造の悪化を抑制する成分のスクリーニング方法
CN114292894A (zh) * 2022-01-14 2022-04-08 广东悠质检测技术有限公司 一种用体外细胞评价化妆品及原料紧致功效的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160243023A1 (en) * 2015-02-19 2016-08-25 Elc Management Llc Novel Skin Remodeling Strategy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000350778A (ja) * 1999-04-20 2000-12-19 L'oreal Sa 加齢した皮膚等価物、それらの調製方法及びそれらの用途
JP2006137744A (ja) * 2004-10-14 2006-06-01 Shiseido Co Ltd Ａｄａｍ活性阻害物質によるしわの防止または改善

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003225369A1 (en) * 2003-04-11 2004-11-01 Coreana Cosmetics Co., Ltd. Medicinal cosmetical composition with areca catechu seed extract
JPWO2004075621A1 (ja) * 2004-03-11 2007-08-23 株式会社資生堂 抗老化剤およびコラーゲン産生促進剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000350778A (ja) * 1999-04-20 2000-12-19 L'oreal Sa 加齢した皮膚等価物、それらの調製方法及びそれらの用途
JP2006137744A (ja) * 2004-10-14 2006-06-01 Shiseido Co Ltd Ａｄａｍ活性阻害物質によるしわの防止または改善

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOSSET S. ET AL.: "Decreased expression of keratinocyte betal integrins in chronically sun-exposed skin in vivo", BR. J. DERMATOL., vol. 148, no. 4, 2003, pages 770 - 778, XP002460365 *
LENAERS C. ET AL.: "Hifu no Auto Lifting Tokusei no Chosei ni yoru Kakushinteki Anti Aging", FRAGR. J., vol. 34, no. 10, 2006, pages 87 - 92 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011219454A (ja) * 2010-03-24 2011-11-04 Fancl Corp 細胞間接着剤
JP2016187324A (ja) * 2015-03-30 2016-11-04 ポーラ化成工業株式会社 タルミ改善剤のスクリーニング法
WO2019225728A1 (ja) * 2018-05-25 2019-11-28 ポーラ化成工業株式会社 加齢又は低酸素による皮膚の状態を改善する成分のスクリーニング方法並びに皮下組織の粘弾性を指標とする皮下組織の酸素レベル又は皮下脂肪細胞の線維化レベルの推定方法
JP2020051869A (ja) * 2018-09-26 2020-04-02 ポーラ化成工業株式会社 コラーゲン線維の結束度を指標とする、低酸素条件及び／又は加齢による、コラーゲン構造の悪化を抑制する成分のスクリーニング方法
JP7280676B2 (ja) 2018-09-26 2023-05-24 ポーラ化成工業株式会社 コラーゲン線維の結束度を指標とする、低酸素条件及び／又は加齢による、コラーゲン構造の悪化を抑制する成分のスクリーニング方法
CN114292894A (zh) * 2022-01-14 2022-04-08 广东悠质检测技术有限公司 一种用体外细胞评价化妆品及原料紧致功效的方法
CN114292894B (zh) * 2022-01-14 2023-08-11 广东悠质检测技术有限公司 一种用体外细胞评价化妆品及原料紧致功效的方法

Also Published As

Publication number Publication date
US20100081162A1 (en) 2010-04-01
JPWO2008108155A1 (ja) 2010-06-10
TW200942813A (en) 2009-10-16

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