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WO2008107777A3 - Improved method for the preparation of desloratadine with reduced levels of organic solvents - Google Patents

Improved method for the preparation of desloratadine with reduced levels of organic solvents Download PDF

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Publication number
WO2008107777A3
WO2008107777A3 PCT/IB2008/000498 IB2008000498W WO2008107777A3 WO 2008107777 A3 WO2008107777 A3 WO 2008107777A3 IB 2008000498 W IB2008000498 W IB 2008000498W WO 2008107777 A3 WO2008107777 A3 WO 2008107777A3
Authority
WO
WIPO (PCT)
Prior art keywords
desloratadine
preparation
organic solvents
improved method
reduced levels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/000498
Other languages
French (fr)
Other versions
WO2008107777A2 (en
Inventor
Sanjay Muktawat
Sanjay Laxmanbhai Patel
Udai Pratap Singh
Ravi Ponnaiah
Bakulesh Mafatlal Khamar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cadila Pharmaceuticals Ltd
Original Assignee
Cadila Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd filed Critical Cadila Pharmaceuticals Ltd
Publication of WO2008107777A2 publication Critical patent/WO2008107777A2/en
Anticipated expiration legal-status Critical
Publication of WO2008107777A3 publication Critical patent/WO2008107777A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved method for the preparation of Desloratadine with reduced levels of organic solvents. Further the invention also relates to a process for the preparation of Desloratadine containing reduced level of chloroform and hexane in Desloratadine to meet ICH specifications. The invention also relates to provide Desloratadine in mixture of polymorphic form 1 and form 2.
PCT/IB2008/000498 2007-03-06 2008-03-05 Improved method for the preparation of desloratadine with reduced levels of organic solvents Ceased WO2008107777A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN422MU2007 2007-03-06
IN422/MUM/2007 2007-03-06

Publications (2)

Publication Number Publication Date
WO2008107777A2 WO2008107777A2 (en) 2008-09-12
WO2008107777A3 true WO2008107777A3 (en) 2009-12-23

Family

ID=39738870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/000498 Ceased WO2008107777A2 (en) 2007-03-06 2008-03-05 Improved method for the preparation of desloratadine with reduced levels of organic solvents

Country Status (1)

Country Link
WO (1) WO2008107777A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659716A (en) * 1984-02-15 1987-04-21 Schering Corporation Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
US20040229896A1 (en) * 2003-03-12 2004-11-18 Toth Zoltan G. Stable pharmaceutical compositions of desloratadine
US20060100435A1 (en) * 2002-09-24 2006-05-11 Sanjay Suri Process for the production of desloratadine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659716A (en) * 1984-02-15 1987-04-21 Schering Corporation Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
US20060100435A1 (en) * 2002-09-24 2006-05-11 Sanjay Suri Process for the production of desloratadine
US20040229896A1 (en) * 2003-03-12 2004-11-18 Toth Zoltan G. Stable pharmaceutical compositions of desloratadine
US20040242619A1 (en) * 2003-03-12 2004-12-02 Toth Zoltan G. Processes for preparation of polymorphic forms of desloratadine

Also Published As

Publication number Publication date
WO2008107777A2 (en) 2008-09-12

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