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WO2008106659A3 - Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith - Google Patents

Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith Download PDF

Info

Publication number
WO2008106659A3
WO2008106659A3 PCT/US2008/055562 US2008055562W WO2008106659A3 WO 2008106659 A3 WO2008106659 A3 WO 2008106659A3 US 2008055562 W US2008055562 W US 2008055562W WO 2008106659 A3 WO2008106659 A3 WO 2008106659A3
Authority
WO
WIPO (PCT)
Prior art keywords
memory
cognitive impairment
associated therewith
impairment associated
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/055562
Other languages
French (fr)
Other versions
WO2008106659A2 (en
Inventor
David Lowe
Christopher J Leonard
Vivo Michael De
Geoffrey Tombaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memory Pharmaceuticals Corp
Original Assignee
Memory Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharmaceuticals Corp filed Critical Memory Pharmaceuticals Corp
Publication of WO2008106659A2 publication Critical patent/WO2008106659A2/en
Publication of WO2008106659A3 publication Critical patent/WO2008106659A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The present invention is a method of treating or preventing mixed and/or manic episodes associated with bipolar I disorder or memory and/or cognitive impairment associated therewith in a patient in need thereof by administering an effective amount of at least one calcium channel modulator selected from (1 ) amlodipine, bepridil, clevidipine, felodipine, isradipine, lacidipine, lercanidipine, manidipine, niguldipine, nilvadipine, nisoldipine, or nitrendipine, or (2) the R-enantiomer of a 1,4-dihydropyridine compound, other than (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)- l,4- dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate.
PCT/US2008/055562 2007-03-01 2008-02-29 Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith Ceased WO2008106659A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89245507P 2007-03-01 2007-03-01
US60/892,455 2007-03-01

Publications (2)

Publication Number Publication Date
WO2008106659A2 WO2008106659A2 (en) 2008-09-04
WO2008106659A3 true WO2008106659A3 (en) 2008-10-16

Family

ID=39721861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/055562 Ceased WO2008106659A2 (en) 2007-03-01 2008-02-29 Methods of treating bipolar disorder and memory and/or cognitive impairment associated therewith

Country Status (1)

Country Link
WO (1) WO2008106659A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820691B2 (en) 2006-08-28 2010-10-26 Medipropharma, Inc. Indoloquinoline compounds as calcium channel blockers
WO2014052849A1 (en) * 2012-09-28 2014-04-03 Elan Pharmaceuticals, Inc. Combination treatments for bipolar disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567271A (en) * 1977-06-20 1986-01-28 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles
US6458808B1 (en) * 2000-12-20 2002-10-01 Osmotica Corp. Pharmaceutical composition for the treatment of cognitive cerebrovascular disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567271A (en) * 1977-06-20 1986-01-28 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles
US6458808B1 (en) * 2000-12-20 2002-10-01 Osmotica Corp. Pharmaceutical composition for the treatment of cognitive cerebrovascular disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SINGH ET AL.: "Renewed Interest in Calcium Channel as Antimania Agents in the Third Millenium", HONG KONG JOURNAL OF PSYCHIATRY, vol. 14, no. 2, 2004, pages 12 - 15 *
SKOLNICK: "New Pharmacological Strategies", 1997, HUMANA PRESS, TOTOWA, NEW JERSEY, ISBN: 0806034690, article PUCILOWSKI ET AL.: "Calcium Channel Antagonists in Mood Disorders, in Antidepressants", pages: 81 - 102 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US8889190B2 (en) 2013-03-13 2014-11-18 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US10363224B2 (en) 2013-03-13 2019-07-30 Upsher-Smith Laboratories, Llc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US9555005B2 (en) 2013-03-15 2017-01-31 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US10172878B2 (en) 2013-03-15 2019-01-08 Upsher-Smith Laboratories, Llc Extended-release topiramate capsules

Also Published As

Publication number Publication date
WO2008106659A2 (en) 2008-09-04

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