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WO2008105499A1 - 歯の製造方法及びこれにより得られた歯 - Google Patents

歯の製造方法及びこれにより得られた歯 Download PDF

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Publication number
WO2008105499A1
WO2008105499A1 PCT/JP2008/053529 JP2008053529W WO2008105499A1 WO 2008105499 A1 WO2008105499 A1 WO 2008105499A1 JP 2008053529 W JP2008053529 W JP 2008053529W WO 2008105499 A1 WO2008105499 A1 WO 2008105499A1
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WO
WIPO (PCT)
Prior art keywords
tooth
cell
production
produced
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053529
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English (en)
French (fr)
Inventor
Takashi Tsuji
Nobuo Sakuragawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo University of Science
Nidek Co Ltd
Kitasato Gakuen Foundation
Organ Technologies Inc
Original Assignee
Tokyo University of Science
Nidek Co Ltd
Kitasato Gakuen Foundation
Organ Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo University of Science, Nidek Co Ltd, Kitasato Gakuen Foundation, Organ Technologies Inc filed Critical Tokyo University of Science
Priority to EP08712100A priority Critical patent/EP2130909A4/en
Priority to CA002679417A priority patent/CA2679417A1/en
Priority to US12/528,936 priority patent/US8349608B2/en
Priority to AU2008219982A priority patent/AU2008219982B2/en
Priority to CN200880006321A priority patent/CN101679946A/zh
Publication of WO2008105499A1 publication Critical patent/WO2008105499A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3865—Dental/periodontal tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/097—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells oral mucosa cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C12N2506/025—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

　本発明は、支持担体の内部に、羊膜由来間葉系細胞及び上皮系細胞のいずれか一方のみから実質的になる第１の細胞集合体と、いずれか他方のみから実質的になる第２の細胞集合体とを混合することなく密着させて配置すること、前記第１及び第２の細胞集合体を前記支持担体の内部で培養すること、により歯を製造する製造方法を開示する。
PCT/JP2008/053529 2007-02-28 2008-02-28 歯の製造方法及びこれにより得られた歯 Ceased WO2008105499A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08712100A EP2130909A4 (en) 2007-02-28 2008-02-28 METHOD OF PRODUCING TOOTH AND TOOTH PRODUCED BY THE METHOD
CA002679417A CA2679417A1 (en) 2007-02-28 2008-02-28 Method for production of tooth, and tooth produced by the method
US12/528,936 US8349608B2 (en) 2007-02-28 2008-02-28 Method for production of tooth, and tooth produced by the method
AU2008219982A AU2008219982B2 (en) 2007-02-28 2008-02-28 Method for production of tooth, and tooth produced by the method
CN200880006321A CN101679946A (zh) 2007-02-28 2008-02-28 牙的制造方法及由该方法得到的牙

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-049128 2007-02-28
JP2007049128A JP2008206500A (ja) 2007-02-28 2007-02-28 歯の製造方法及びこれにより得られた歯

Publications (1)

Publication Number Publication Date
WO2008105499A1 true WO2008105499A1 (ja) 2008-09-04

Family

ID=39721323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053529 Ceased WO2008105499A1 (ja) 2007-02-28 2008-02-28 歯の製造方法及びこれにより得られた歯

Country Status (9)

Country Link
US (1) US8349608B2 (ja)
EP (1) EP2130909A4 (ja)
JP (1) JP2008206500A (ja)
KR (1) KR20100014573A (ja)
CN (1) CN101679946A (ja)
AU (1) AU2008219982B2 (ja)
CA (1) CA2679417A1 (ja)
RU (1) RU2462256C2 (ja)
WO (1) WO2008105499A1 (ja)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
WO2012108069A1 (ja) * 2011-02-09 2012-08-16 株式会社オーガンテクノロジーズ ガイドを有する移植用再生器官原基の製造方法、当該方法によって製造される、ガイドを有する移植用再生器官原基を含む組成物、およびガイドを有する移植用再生器官原基の移植方法
WO2013047639A1 (ja) * 2011-09-27 2013-04-04 公立大学法人横浜市立大学 組織及び臓器の作製方法

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AU2009283516B2 (en) * 2008-08-20 2014-02-13 Organ Technologies Inc. Method for restoring missing tooth and method for producing restorative material
JP5660896B2 (ja) * 2008-09-05 2015-01-28 学校法人 日本歯科大学 歯根・歯周組織ユニット形成方法、及び再生歯
JP5492791B2 (ja) 2009-01-28 2014-05-14 株式会社オーガンテクノロジーズ 歯の製造方法
US10022202B2 (en) 2013-03-15 2018-07-17 Triagenics, Llc Therapeutic tooth bud ablation
CA2939815C (en) 2009-05-11 2020-08-25 Triagenics, Llc Therapeutic tooth bud ablation
WO2014143014A1 (en) 2013-03-15 2014-09-18 Triagenics, Llc Therapeutic tooth bud ablation
AU2011236302B2 (en) 2010-04-07 2014-05-01 Organ Technologies, Inc. Methods for manufacturing a regenerated tooth unit
CN102335457A (zh) * 2010-07-28 2012-02-01 郭山辉 用于再生牙齿的组合物
CN102002477B (zh) * 2010-12-01 2012-08-22 四川大学 牙源性上皮细胞的培养和扩增方法
CA2820445A1 (en) * 2010-12-20 2012-06-28 Stemnion, Inc. Methods for treating dental diseases, disorders, and injuries
KR101854490B1 (ko) 2011-02-24 2018-05-03 가부시키가이샤 오간 테크놀로지즈 모색이 제어된 이식용 재생 모낭 원기의 제조방법, 당해 이식용 재생 모낭 원기를 포함하는 조성물 및 그의 이식방법
WO2013115128A1 (ja) 2012-02-01 2013-08-08 株式会社オーガンテクノロジーズ 歯科用インプラントおよびその製造方法
EP2633870B1 (en) 2012-02-29 2018-08-01 Technische Universität Berlin Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom
US9438264B1 (en) 2015-09-10 2016-09-06 Realtek Semiconductor Corp. High-speed capacitive digital-to-analog converter and method thereof
US12440605B2 (en) 2018-06-04 2025-10-14 Organ Technologies, Inc. Method for producing regenerated hair follicle primordium
EP3979938B1 (en) 2019-06-06 2024-07-24 TriAgenics, Inc. Ablation probe systems

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012108069A1 (ja) * 2011-02-09 2012-08-16 株式会社オーガンテクノロジーズ ガイドを有する移植用再生器官原基の製造方法、当該方法によって製造される、ガイドを有する移植用再生器官原基を含む組成物、およびガイドを有する移植用再生器官原基の移植方法
CN103476925A (zh) * 2011-02-09 2013-12-25 株式会社器官再生工学 具有导引器的移植用再生器官原基的制造方法、包含由其制造的具有导引器的移植用再生器官原基的组合物和具有导引器的移植用再生器官原基的移植方法
CN103476925B (zh) * 2011-02-09 2016-02-17 株式会社器官再生工学 具有导引器的移植用再生器官原基的制造方法、包含由其制造的具有导引器的移植用再生器官原基的组合物和具有导引器的移植用再生器官原基的移植方法
JP5932671B2 (ja) * 2011-02-09 2016-06-08 株式会社オーガンテクノロジーズ ガイドを有する移植用再生器官原基の製造方法、当該方法によって製造される、ガイドを有する移植用再生器官原基を含む組成物、およびガイドを有する移植用再生器官原基の移植方法
US9982238B2 (en) 2011-02-09 2018-05-29 Organ Technologies, Inc. Method for producing regenerative organ primordium provided with guide for transplantation, composition containing regenerative organ primordium provided with guide for transplantation produced thereby, and method for transplanting regenerative organ primordium provided with guide for transplantation
WO2013047639A1 (ja) * 2011-09-27 2013-04-04 公立大学法人横浜市立大学 組織及び臓器の作製方法
US11326150B2 (en) 2011-09-27 2022-05-10 Public University Corporation Yokohama City University Method for producing tissue and organ

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CN101679946A (zh) 2010-03-24
US20100129771A1 (en) 2010-05-27
CA2679417A1 (en) 2008-09-04
KR20100014573A (ko) 2010-02-10
EP2130909A1 (en) 2009-12-09
US8349608B2 (en) 2013-01-08
JP2008206500A (ja) 2008-09-11
EP2130909A4 (en) 2010-04-07
RU2462256C2 (ru) 2012-09-27
RU2009135689A (ru) 2011-04-10
AU2008219982A1 (en) 2008-09-04

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