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WO2008101469A3 - Pharmaceutical preparation for treating metastases - Google Patents

Pharmaceutical preparation for treating metastases Download PDF

Info

Publication number
WO2008101469A3
WO2008101469A3 PCT/DE2008/000264 DE2008000264W WO2008101469A3 WO 2008101469 A3 WO2008101469 A3 WO 2008101469A3 DE 2008000264 W DE2008000264 W DE 2008000264W WO 2008101469 A3 WO2008101469 A3 WO 2008101469A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical preparation
treating metastases
substance
lipids
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2008/000264
Other languages
German (de)
French (fr)
Other versions
WO2008101469A2 (en
Inventor
Reinhardt Zeisig
Iduna Fichtner
Jane Wenzel
Christian Nowak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Original Assignee
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft filed Critical Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Publication of WO2008101469A2 publication Critical patent/WO2008101469A2/en
Publication of WO2008101469A3 publication Critical patent/WO2008101469A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel pharmaceutical preparations and their use for the production of drugs for treating metastases, based on liposomes. These preparations are liposomal formulations. According to the invention, these formulations comprise at least one substance having an anti-tumor effect and at least one substance having an anti-coagulation effect, in addition to potentially present further agents. Particularly they are made of base lipids and optionally further components, such as helper lipids, membrane stabilizers, and charge carriers, and may have a modified surface for improving their effectiveness.
PCT/DE2008/000264 2007-02-19 2008-02-14 Pharmaceutical preparation for treating metastases Ceased WO2008101469A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007008484.8 2007-02-19
DE102007008484A DE102007008484A1 (en) 2007-02-19 2007-02-19 Pharmaceutical preparation for the control of metastases

Publications (2)

Publication Number Publication Date
WO2008101469A2 WO2008101469A2 (en) 2008-08-28
WO2008101469A3 true WO2008101469A3 (en) 2009-01-29

Family

ID=39529675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2008/000264 Ceased WO2008101469A2 (en) 2007-02-19 2008-02-14 Pharmaceutical preparation for treating metastases

Country Status (2)

Country Link
DE (1) DE102007008484A1 (en)
WO (1) WO2008101469A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106541A (en) * 2015-01-28 2017-08-29 瑞采生技有限公司 Compounds for enhancing PPAR γ expression and nuclear translocation and medical uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466716A (en) * 1990-12-31 1995-11-14 The Biomembrane Institute Liposomal trimethylsphingosine
US20050288251A1 (en) * 2004-03-16 2005-12-29 The General Hospital Corporation Treatment and prevention of abnormal cellular proliferation
WO2006024675A1 (en) * 2004-09-03 2006-03-09 Forschungszentrum Karlsruhe Gmbh Use of alkylphospholipids for the treatment of solid tumours

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
EP1839648A3 (en) * 1998-11-12 2007-11-21 Transave, Inc. An inhalation system
ES2185418T3 (en) * 1998-12-04 2003-04-16 Max Delbrueck Centrum AGENTS INTENDED TO TREAT TUMORS, BASED ON LIPOSOMES AND CONTAINING TAMOXIFEN.
WO2002057273A1 (en) * 2001-01-20 2002-07-25 Trigen Limited Serine protease inhibitors comprising a hydrogen-bond acceptor
WO2002060894A2 (en) * 2001-01-30 2002-08-08 Bristol-Myers Squibb Company Sulfonamide lactam inhibitors of factor xa
US7081460B2 (en) * 2001-04-09 2006-07-25 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
EP1416974A1 (en) * 2001-08-16 2004-05-12 Bristol-Myers Squibb Pharma Company Gas microsphere liposome composites

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466716A (en) * 1990-12-31 1995-11-14 The Biomembrane Institute Liposomal trimethylsphingosine
US20050288251A1 (en) * 2004-03-16 2005-12-29 The General Hospital Corporation Treatment and prevention of abnormal cellular proliferation
WO2006024675A1 (en) * 2004-09-03 2006-03-09 Forschungszentrum Karlsruhe Gmbh Use of alkylphospholipids for the treatment of solid tumours

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
D. ARNDT ET AL.: "Alkylphospholipid liposomes: preparation, properties and use in cancer research", DRUGS OF TODAY, vol. 34, 1998, pages 83 - 96, XP008059034 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; XP002503801, retrieved from EPO Database accession no. PREV200510270367 *
E. DIAL ET AL.: "Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro.", CANCER CHEMOTER PHARMACOL, vol. 57, 2006, pages 295 - 300, XP019334299 *
H. HAN ET AL.: "In vivo distribution and antitumor activity of heparin stabilized doxorubicin-loaded liposomes", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 313, 2006, pages 181 - 188, XP005353546 *
R. BAZ ET AL.: "Aspirin decreases the thrombotic complications (DVT) of liposomal doxorubicin, vincristine, decreased frequency dexamethasone and thalidomide (DVd-T) treatment of multiple myeloma (MM)", BLOOD, vol. 104, no. 11, 2004, pages 658A - 659A *
R. MOOG ET AL.: "Enhanced in vivo anticancer efficacy of gemcitabine after encapsulation into vesicular phospholipid gels", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, vol. 26, 1999, pages 48 - 48, XP008098661 *
T. CHOU ET AL.: "Effect of composition on the stability of liposomal irinotecan prepared by a pH gradient method.", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 95, no. 4, 2003, pages 405 - 408, XP002503800 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106541A (en) * 2015-01-28 2017-08-29 瑞采生技有限公司 Compounds for enhancing PPAR γ expression and nuclear translocation and medical uses thereof

Also Published As

Publication number Publication date
DE102007008484A1 (en) 2008-08-21
WO2008101469A2 (en) 2008-08-28

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