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WO2008157365A3 - Vinylazacycloalkanes for treating neuropathic pain - Google Patents

Vinylazacycloalkanes for treating neuropathic pain Download PDF

Info

Publication number
WO2008157365A3
WO2008157365A3 PCT/US2008/066939 US2008066939W WO2008157365A3 WO 2008157365 A3 WO2008157365 A3 WO 2008157365A3 US 2008066939 W US2008066939 W US 2008066939W WO 2008157365 A3 WO2008157365 A3 WO 2008157365A3
Authority
WO
WIPO (PCT)
Prior art keywords
neuropathic pain
vinylazacycloalkanes
treating neuropathic
treating
invention includes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/066939
Other languages
French (fr)
Other versions
WO2008157365A2 (en
Inventor
Merouane Bencherif
Kristen G Jordan
Patrick M Lippiello
Beth Fordham-Meier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyre Therapeutics Inc
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of WO2008157365A2 publication Critical patent/WO2008157365A2/en
Publication of WO2008157365A3 publication Critical patent/WO2008157365A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention includes methods and compositions for treating or preventing neuropathic pain. The present invention includes compounds for use in treating or preventing neuropathic pain. The present invention includes the use of compounds in the manufacture of a medicament for the treatment or prevention of neuropathic pain.
PCT/US2008/066939 2007-06-15 2008-06-13 Vinylazacycloalkanes for treating neuropathic pain Ceased WO2008157365A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94429407P 2007-06-15 2007-06-15
US60/944,294 2007-06-15

Publications (2)

Publication Number Publication Date
WO2008157365A2 WO2008157365A2 (en) 2008-12-24
WO2008157365A3 true WO2008157365A3 (en) 2009-04-16

Family

ID=39711086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/066939 Ceased WO2008157365A2 (en) 2007-06-15 2008-06-13 Vinylazacycloalkanes for treating neuropathic pain

Country Status (1)

Country Link
WO (1) WO2008157365A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
RU2533819C2 (en) * 2008-12-01 2014-11-20 Таргасепт, Инк. Synthesis and new saline forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
US20130237550A1 (en) * 2010-03-11 2013-09-12 Targacept, Inc. Arylvinylazacycloalkane compounds for constipation
WO2017177024A1 (en) * 2016-04-07 2017-10-12 Oyster Point Pharma, Inc. Methods of treating ocular conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078752A1 (en) * 2003-03-05 2004-09-16 Targacept Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
WO2007099828A1 (en) * 2006-02-23 2007-09-07 Shionogi & Co., Ltd. Nirogenous heterocyclic derivatives substituted with cyclic groups

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078752A1 (en) * 2003-03-05 2004-09-16 Targacept Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
WO2007099828A1 (en) * 2006-02-23 2007-09-07 Shionogi & Co., Ltd. Nirogenous heterocyclic derivatives substituted with cyclic groups
EP1988077A1 (en) * 2006-02-23 2008-11-05 Shionogi & Co., Ltd. Nirogenous heterocyclic derivatives substituted with cyclic groups

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KESINGLAND A C ET AL: "Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain", PAIN, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 86, no. 1-2, 1 May 2000 (2000-05-01), pages 113 - 118, XP002217587, ISSN: 0304-3959 *

Also Published As

Publication number Publication date
WO2008157365A2 (en) 2008-12-24

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