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WO2008151927A3 - 6-n-substituted benz imidazole derivatives as acid pump antagonists - Google Patents

6-n-substituted benz imidazole derivatives as acid pump antagonists Download PDF

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Publication number
WO2008151927A3
WO2008151927A3 PCT/EP2008/056478 EP2008056478W WO2008151927A3 WO 2008151927 A3 WO2008151927 A3 WO 2008151927A3 EP 2008056478 W EP2008056478 W EP 2008056478W WO 2008151927 A3 WO2008151927 A3 WO 2008151927A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazole derivatives
acid pump
benz imidazole
pump antagonists
substituted benz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/056478
Other languages
French (fr)
Other versions
WO2008151927A2 (en
Inventor
Peter Jan Zimmermann
Christof Brehm
Andreas Palmer
Wilm Buhr
Joerg Senn-Bilfinger
Wolfgang-Alexander Simon
Michael Herrmann
Stefan Postius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Nycomed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed GmbH filed Critical Nycomed GmbH
Publication of WO2008151927A2 publication Critical patent/WO2008151927A2/en
Publication of WO2008151927A3 publication Critical patent/WO2008151927A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides compounds of the formula (0), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
PCT/EP2008/056478 2007-06-15 2008-05-27 6-n-substituted benz imidazole derivatives as acid pump antagonists Ceased WO2008151927A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07110341.0 2007-06-15
EP07110341 2007-06-15
EP07111054.8 2007-06-26
EP07111054 2007-06-26

Publications (2)

Publication Number Publication Date
WO2008151927A2 WO2008151927A2 (en) 2008-12-18
WO2008151927A3 true WO2008151927A3 (en) 2009-04-09

Family

ID=40070887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/056478 Ceased WO2008151927A2 (en) 2007-06-15 2008-05-27 6-n-substituted benz imidazole derivatives as acid pump antagonists

Country Status (1)

Country Link
WO (1) WO2008151927A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2452680B1 (en) 2009-07-09 2019-12-18 RaQualia Pharma Inc. Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility
EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
HK1252562A1 (en) 2015-06-08 2019-05-31 Hk Inno.N Corporation Uses of benzimidazole derivative for nocturnal acid breakthrough
KR20170016754A (en) * 2015-08-04 2017-02-14 씨제이헬스케어 주식회사 New method for preparation of chromanone derivatives
KR101769204B1 (en) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 New method for preparation of chiral chromanol derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047603A1 (en) * 1996-06-10 1997-12-18 Astra Aktiebolag New compounds
WO2004054984A1 (en) * 2002-12-13 2004-07-01 Altana Pharma Ag 4-substituted benzimidazoles and their use as inhibitors of gastric secretion
WO2004087701A1 (en) * 2003-04-04 2004-10-14 Altana Pharma Ag Cyclic benzimidazoles
WO2006134460A1 (en) * 2005-06-14 2006-12-21 Pfizer Japan Inc. Chromane substituted benzimidazole derivatives as acid pump antagonists
WO2006134111A1 (en) * 2005-06-16 2006-12-21 Nycomed Gmbh Spiro-benzimidazoles as inhibitors of gastric acid secretion
WO2007003386A1 (en) * 2005-06-30 2007-01-11 Glaxo Group Limited Imidazopyridine derivatives as acid pump antagonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997047603A1 (en) * 1996-06-10 1997-12-18 Astra Aktiebolag New compounds
WO2004054984A1 (en) * 2002-12-13 2004-07-01 Altana Pharma Ag 4-substituted benzimidazoles and their use as inhibitors of gastric secretion
WO2004087701A1 (en) * 2003-04-04 2004-10-14 Altana Pharma Ag Cyclic benzimidazoles
WO2006134460A1 (en) * 2005-06-14 2006-12-21 Pfizer Japan Inc. Chromane substituted benzimidazole derivatives as acid pump antagonists
WO2006134111A1 (en) * 2005-06-16 2006-12-21 Nycomed Gmbh Spiro-benzimidazoles as inhibitors of gastric acid secretion
WO2007003386A1 (en) * 2005-06-30 2007-01-11 Glaxo Group Limited Imidazopyridine derivatives as acid pump antagonists

Also Published As

Publication number Publication date
WO2008151927A2 (en) 2008-12-18

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