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WO2008151197A8 - Tumor-derived endogenous toll-like receptor 4 ligands - Google Patents

Tumor-derived endogenous toll-like receptor 4 ligands Download PDF

Info

Publication number
WO2008151197A8
WO2008151197A8 PCT/US2008/065672 US2008065672W WO2008151197A8 WO 2008151197 A8 WO2008151197 A8 WO 2008151197A8 US 2008065672 W US2008065672 W US 2008065672W WO 2008151197 A8 WO2008151197 A8 WO 2008151197A8
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
tumor
receptor
derived endogenous
inducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/065672
Other languages
French (fr)
Other versions
WO2008151197A3 (en
WO2008151197A2 (en
Inventor
Gang Zeng
Xiaoli Tian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of WO2008151197A2 publication Critical patent/WO2008151197A2/en
Publication of WO2008151197A3 publication Critical patent/WO2008151197A3/en
Publication of WO2008151197A8 publication Critical patent/WO2008151197A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are proteins, compositions and methods for inducing dendritic cell activation, maturation, polarization, and/or filamentous actin rearrangement in immature dendritic cells, inducing immune responses in subjects, targeting or a dendritic cell for phagocytosis or TLR4 signaling, and reversing, inhibiting, or reducing immune suppression by a cancer in a subject.
PCT/US2008/065672 2007-06-04 2008-06-03 Tumor-derived endogenous toll-like receptor 4 ligands Ceased WO2008151197A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94171207P 2007-06-04 2007-06-04
US60/941,712 2007-06-04

Publications (3)

Publication Number Publication Date
WO2008151197A2 WO2008151197A2 (en) 2008-12-11
WO2008151197A3 WO2008151197A3 (en) 2009-01-29
WO2008151197A8 true WO2008151197A8 (en) 2009-07-30

Family

ID=40094397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/065672 Ceased WO2008151197A2 (en) 2007-06-04 2008-06-03 Tumor-derived endogenous toll-like receptor 4 ligands

Country Status (1)

Country Link
WO (1) WO2008151197A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2869828B1 (en) * 2012-07-09 2018-01-03 The Regents of The University of California Vault immunotherapy
EP3604271A1 (en) 2013-06-28 2020-02-05 Auckland Uniservices Limited Peptides for amino acid and peptide conjugates and conjugation process
CN107250103A (en) 2014-12-23 2017-10-13 玛格丽特·安妮·布林布尔 Amino acid and peptide conjugates and uses thereof
WO2017145097A2 (en) 2016-02-26 2017-08-31 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723832B1 (en) * 1996-10-03 2004-04-20 Ludwig Institute For Cancer Research Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof

Also Published As

Publication number Publication date
WO2008151197A3 (en) 2009-01-29
WO2008151197A2 (en) 2008-12-11

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