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WO2008150242A1 - Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique - Google Patents

Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique Download PDF

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Publication number
WO2008150242A1
WO2008150242A1 PCT/SG2007/000161 SG2007000161W WO2008150242A1 WO 2008150242 A1 WO2008150242 A1 WO 2008150242A1 SG 2007000161 W SG2007000161 W SG 2007000161W WO 2008150242 A1 WO2008150242 A1 WO 2008150242A1
Authority
WO
WIPO (PCT)
Prior art keywords
value
central aortic
blood pressure
arterial waveform
aortic systolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SG2007/000161
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English (en)
Inventor
Choon Meng Ting
Ngak Hwee Chua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Healthstats International Pte Ltd
Original Assignee
Healthstats International Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0721728A priority Critical patent/BRPI0721728A2/pt
Priority to GB0723145.9A priority patent/GB2454624B/en
Priority to AU2007354717A priority patent/AU2007354717B2/en
Priority to PCT/SG2007/000161 priority patent/WO2008150242A1/fr
Priority to CA2689278A priority patent/CA2689278C/fr
Priority to KR1020097026793A priority patent/KR101476730B1/ko
Priority to JP2010511149A priority patent/JP2010528757A/ja
Priority to MX2009013200A priority patent/MX2009013200A/es
Application filed by Healthstats International Pte Ltd filed Critical Healthstats International Pte Ltd
Priority to EP07748706.4A priority patent/EP2162063A4/fr
Priority to TW097115022A priority patent/TWI441618B/zh
Publication of WO2008150242A1 publication Critical patent/WO2008150242A1/fr
Priority to ZA2009/08221A priority patent/ZA200908221B/en
Priority to IL202333A priority patent/IL202333A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02116—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate

Definitions

  • the invention relates to a method of deriving the central aortic systolic pressure and a method of analysing arterial waveform data to derive central aortic systolic pressure values.
  • the invention is particularly suited to deriving the central aortic systolic pressure from an arterial waveform.
  • the invention is suited towards analysing an arterial waveform dataset to derive a corresponding central aortic systolic pressure dataset.
  • Heart disease is a serious health problem in developed countries.
  • One indicator of potential heart disease is variances in the blood pressure of the living body from a designated range of "normal" values.
  • a common method of determining the blood pressure of a living body is to take a brachial blood pressure reading (both systolic and diastolic) of the living body using a pressure cuff. These values are commonly then used as surrogate central aortic pressure values. While this assumption has historically been proven as beneficial in indicating potential heart disease, recent studies have shown that a "normal" brachial blood pressure value measured in this manner may mask abnormal central aortic systolic pressure values.
  • Atcor Medical Pty Ltd of West Ryde, New South Wales, Australia. Atcor's solution uses a proprietary transfer formula to convert a radial pressure waveform to a central aortic blood pressure waveform.
  • this formula is only available through proprietary software made commercially available by Atcor for use with its SphygmoCorTM blood pressure monitoring system. More importantly, the formula is based on a correlation value determined through testing on a cross-representation of patients and therefore may introduce error in central aortic pressure readings on patients that fall outside the realms of the cross-representative sample.
  • the term "living body" is a reference to the body at the time of generation of the arterial waveform.
  • the invention is not to be considered as limited to exclude the calculation of a central aortic pressure value from an arterial waveform of a since deceased patient.
  • steps c. and d. are repeated with the value of f commencing at 1 and being incremented by 1 each time until the value of f plus the integer interval value equals the predetermined number of blood pressure measurements in the set.
  • the set of blood pressure measurements should substantially equate to a uniform distribution of values from the arterial waveform.
  • the method preferably includes the step of determining the duration of the arterial waveform.
  • the duration of the wave form can then be used to determine the predetermined number according to the following formula:
  • sr the sample rate, in Hz, of a measuring device used to record the blood pressure measurements in the set
  • the integer interval value may be division of the sample rate. Ideally, however, the integer interval value is the sample rate divided by 4.
  • the integer interval value may be a division of the predetermined number of blood pressure measurements in the set of blood pressure measurements. Ideally, using this technique, the integer interval value may fall within a range the boundaries of which are determined as follows:
  • n is the predetermined number of blood pressure measurements in the set
  • t is the duration of the waveform (in seconds)
  • v is a predetermined division value
  • the value of v be set to 4.
  • the integer interval value is equal to 60 divided by a predetermined division value. In another alternative configuration, the integer interval value is 15.
  • the predetermined number of blood pressure measurements in the set is equal to or greater than 15. However, it is preferred that the predetermined number of blood pressure measurements in the set is at least 30.
  • the predetermined number of blood pressure measurements in the set is at least 30 and the interval is 15.
  • steps b. through f. are repeated for each arterial waveform in the arterial waveform dataset and, for each such repetition, steps d. and e. are further repeated with the value of f commencing at 1 and being incremented by 1 each time until the value of f plus the integer interval value equals the predetermined number of blood pressure measurements in the set being processed.
  • each arterial waveform in the dataset comprises a representative set of blood pressure measurements having a predetermined number
  • steps b. through e. are repeated for each arterial waveform in the arterial waveform dataset and, for each such repetition, steps c. and d. are further repeated with the value of f commencing at 1 and being incremented by 1 each time until the value of f plus the integer interval value equals the predetermined number of blood pressure measurements in the set being processed.
  • the predetermined number of blood pressure measurements for at least one arterial waveform in the dataset may differ from the predetermined number of blood pressure measurements for the other arterial waveforms in the dataset.
  • the set of blood pressure measurements should substantially equate to a uniform distribution of values from the arterial waveform.
  • the method further includes the step of determining the duration of the arterial waveform.
  • the duration of the wave form can then be used to determine the predetermined number according to the following formula:
  • sr the sample rate, in Hz, of a measuring device used to record the blood pressure measurements in the set
  • the integer interval value may be a division of the sample rate (sr).
  • the integer interval value is the sample rate divided by 4.
  • the integer interval value may be a division of the predetermined number of blood pressure measurements in the set of blood pressure measurements. Ideally, using this technique, the integer interval value is within a range the boundaries of which are determined as follows:
  • n is the predetermined number of blood pressure measurements in the set
  • t the duration of the waveform (in seconds)
  • v is a predetermined division value.
  • the value of v be set to 4.
  • the integer interval value is equal to 60 divided by a predetermined division value. In another alternative configuration, the integer interval value is 15.
  • the predetermined number of blood pressure measurements in the set should be equal to or greater than 15. A set of 30 blood pressure measurements is preferred.
  • the arterial waveform measuring device takes a blood pressure measurement at predetermined intervals until at least one arterial waveform is represented by the set of blood pressure measurements taken, the set of blood pressure measurements representative of one arterial waveform then being communicated to the processing unit which:
  • steps b. and c. are repeated with the value of f commencing at 1 and being incremented by 1 each time until the value of f plus the integer interval value equals the number of blood pressure measurements in the set.
  • Figure 1 is a flow chart of a method of determining the central aortic pressure of a living body in accordance with a first embodiment of the present invention.
  • Figure 2 is a flow chart of a method of analysing an arterial waveform dataset to produce a corresponding central aortic pressure dataset in accordance with a second embodiment of the present invention.
  • Figure 3 is an illustrative arterial waveform that can be processed by any embodiment of the current invention to obtain a central aortic pressure value.
  • the method 10 commences by the creation of a set of blood pressure measurements from a living body representative of an arterial waveform (step 12).
  • the set of blood pressure measurements has a predetermined number of measurements (n).
  • the predetermined number n is divided by a preset value (v) to determine an integer interval value (/).
  • the integer interval value (/) may be subjected to an absolute or rounding mathematical function.
  • the blood pressure measurements ⁇ bp[f ⁇ , bp[f+1], bp[f+2], bp[f+3], .... bp[f+/ ' -1] ⁇ are summed (step 16) to form a value s;
  • the summed value s be divided by the interval value / to form an average blood pressure value (a) (step 18).
  • the average blood pressure value a is stored in a central aortic pressure set of values (step 20).
  • steps 16 to 20 are repeated until f + i- 1 is equal to n.
  • Step 22 sees the central aortic pressure set of values analysed to determine the highest value in the set (h).
  • the highest value h is then used as a value substantially representative of the central aortic systolic pressure of the living body.
  • a method of analysing an arterial waveform dataset to produce a corresponding central aortic pressure dataset 100 there is a method of analysing an arterial waveform dataset to produce a corresponding central aortic pressure dataset 100.
  • a common precursor to this embodiment is that a medical professional obtains an arterial waveform representation of the blood pressure of a living body according to any technique as would be known to the person skilled in the art. This arterial waveform representation is then provided to a central processing station for determination of the corresponding central aortic pressure. Following receipt of the arterial waveform representation the central processing station operates as follows:
  • a corresponding central aortic pressure value a is determined and stored in the central aortic pressure dataset according to the following process.
  • the arterial waveform 102 being processed is divided into a set of representative blood pressure measurements (step 110).
  • the set of blood pressure measurements has a predetermined number of measurements (n).
  • the predetermined number n is divided by a preset value (v) to determine an integer interval value (/).
  • the blood pressure measurements ⁇ bp[f ⁇ , bp[f+1], bp[f+2], bp[f+3], ..., bp[f+/-1] ⁇ are summed (step 114) to form a value s;
  • the summed value s be divided by the interval value / to form an average blood pressure value (a) (step 116).
  • the average blood pressure value a is stored in a central aortic pressure set of values (step 118).
  • steps 114 to 118 are repeated until f+ i- 1 is equal to n.
  • Step 120 sees the central aortic pressure set of values analysed to determine the highest value in the set (h).
  • the highest value h is then stored in the central aortic pressure dataset as the central aortic systolic pressure value corresponding with the arterial waveform processed.
  • n value can be any value in excess of 15.
  • v value 4 to determine an appropriate interval
  • a substantially accurate aortic pressure value has been able to be obtained where the interval value is in a range, the limits of which are determined as follows:
  • variable t is representative of the duration of a single waveform (in seconds).
  • a set of blood pressure measurements from a living body representative of an arterial waveform are created.
  • the measurements are as follows (in order, from left to right, top to bottom):
  • the time duration taken to complete this waveform is 1.27 seconds.
  • the interval value range ⁇ irange is determined as follows:
  • the 'rang e value is restricted to the range of 13 to 17.
  • an / value of 15 shall be used.
  • a central aortic pressure set of values having the following values:
  • the central aortic pressure set of values has 62 elements to it, being the value equal to n - i + 1. From this set, it is apparent that the highest value in the set (h) is in fact the seventh data element (172.4). Accordingly the central aortic systolic pressure of the living body is determined as 172.4.
  • n is determined according to the following formula:
  • sr the sample rate (in hertz) of a measuring device used to record the blood pressure measurements in the set bp;
  • f the time taken (in seconds) to complete one arterial waveform.
  • the blood pressure measurements in the set bp are the measurement values taken by the measuring device at each repetition of the sample rate.
  • the interval value is in a range, the limits of which are determined as follows:
  • sr again represents the sample rate (in hertz) of a measuring device used to record the blood pressure measurements in the set bp.
  • the v value is preferably 4. This formula is only applicable though when the sr value is in excess of 30.
  • the irange value is calculated as follows:
  • the set of blood pressure measurements may be obtained from a device that is also adapted to perform the method of the present invention.
  • the set of blood pressure measurements may be obtained from a separate device and communicated to a further apparatus adapted to perform the method of the present invention.
  • the second embodiment of the invention may be modified such that the waveform dataset does not contain waveforms - in its place the waveform dataset data may contain sets of data representative of such waveforms. In this manner, the processing of step 110 may be omitted.
  • the waveform dataset may be supplied to the entity performing the method along with the duration of each waveform in the dataset.
  • the entity performing the method may determine the duration of each waveform independently through alternate means (such as by receiving graphs having a fixed time value for predetermined lengths of the x axis and approximating the duration of the waveform based on this time/distance relationship or by deriving the duration from other composite values, such as the sample rate used to generate the set of blood pressure measurements).
  • the blood pressure values that form the set bp should be of uniform distribution along the arterial waveform.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

Un procédé de dérivation de la pression systolique aortique centrale, comprenant les étapes suivantes : a) création d'un ensemble ayant un nombre prédéterminé de mesures de pression artérielle, l'ensemble étant représentatif d'une onde artérielle; b) détermination d'une valeur d'intervalle entier; c) calcul de la moyenne d'une série de mesures consécutives de la pression artérielle dans l'ensemble, qui est égale à la valeur d'intervalle entier commençant à la fième valeur de mesure de la pression artérielle; d) stockage de la valeur moyenne dans un ensemble de pression systolique aortique centrale, et e) réglage de la pression systolique aortique à la valeur la plus élevée dans l'ensemble des pressions aortiques centrales, les étapes c et d étant répétées, la valeur f étant incrémentée de 1 à chaque fois, jusqu'à ce que la valeur de f plus la valeur de l'intervalle entier soit éàgale au nombre prédéterminé de mesures de tension artérielle dans l'ensemble.
PCT/SG2007/000161 2007-06-07 2007-06-07 Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique Ceased WO2008150242A1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2010511149A JP2010528757A (ja) 2007-06-07 2007-06-07 中心大動脈収縮期圧を得る方法、及び動脈波形データを分析して中心大動脈収縮期圧値を得る方法
AU2007354717A AU2007354717B2 (en) 2007-06-07 2007-06-07 A method of deriving central aortic systolic pressure and a method of analysing arterial waveform data to derive central aortic systolic pressure values
PCT/SG2007/000161 WO2008150242A1 (fr) 2007-06-07 2007-06-07 Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique
CA2689278A CA2689278C (fr) 2007-06-07 2007-06-07 Procede de derivation de la pression systolique aortique centrale et procede d'analyse des donnees de forme d'onde arterielle pour deriver les valeurs de pression systolique aortique
KR1020097026793A KR101476730B1 (ko) 2007-06-07 2007-06-07 중심 대동맥 수축기압을 나타내는 값의 유도 방법 및 중심 대동맥 수축기압을 나타내는 값을 유도하기 위해 동맥압 파형 데이터를 분석하는 방법
MX2009013200A MX2009013200A (es) 2007-06-07 2007-06-07 Método de derivación de la presóon sistólica aórtica central y método para analizar datos de la onda arterial para derivar valores de presión sistólica aórtica central.
EP07748706.4A EP2162063A4 (fr) 2007-06-07 2007-06-07 Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique
BRPI0721728A BRPI0721728A2 (pt) 2007-06-07 2007-06-07 método para obter a pressão sistólica aórtica central e método de análise de dados de onda arterial para obter valores de pressão sistólica aórtica central
GB0723145.9A GB2454624B (en) 2007-06-07 2007-06-07 A method of deriving central aortic systolic pressure and a method of analysing arterial waveform data to derive central aortic systolic pressure values
TW097115022A TWI441618B (zh) 2007-06-07 2008-04-24 導出中心主動脈心縮壓的方法以及分析動脈波形資料以導出中心主動脈心縮壓數值的方法
ZA2009/08221A ZA200908221B (en) 2007-06-07 2009-11-20 A method of deriving central aortic systolic pressure and a method of analysing arterial waveform data to derive central aortic systolic pressure values
IL202333A IL202333A (en) 2007-06-07 2009-11-25 Method of deriving central aortic systolic pressure and a method of analysing arterial waveform data to derive central aortic systolic pressure values

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2007/000161 WO2008150242A1 (fr) 2007-06-07 2007-06-07 Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique

Publications (1)

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WO2008150242A1 true WO2008150242A1 (fr) 2008-12-11

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PCT/SG2007/000161 Ceased WO2008150242A1 (fr) 2007-06-07 2007-06-07 Procédé de dérivation de la pression systolique aortique centrale et procédé d'analyse des données de forme d'onde artérielle pour dériver les valeurs de pression systolique aortique

Country Status (12)

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EP (1) EP2162063A4 (fr)
JP (1) JP2010528757A (fr)
KR (1) KR101476730B1 (fr)
AU (1) AU2007354717B2 (fr)
BR (1) BRPI0721728A2 (fr)
CA (1) CA2689278C (fr)
GB (1) GB2454624B (fr)
IL (1) IL202333A (fr)
MX (1) MX2009013200A (fr)
TW (1) TWI441618B (fr)
WO (1) WO2008150242A1 (fr)
ZA (1) ZA200908221B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508056A (ja) * 2008-11-10 2012-04-05 ヘルススタッツ インターナショナル ピーティーイー リミテッド 自立神経機能不全テストのパラメータを測定するための方法およびシステム

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US20030236465A1 (en) * 2002-06-20 2003-12-25 Colin Corporation Blood-pressure determining apparatus
WO2005058155A1 (fr) * 2003-12-17 2005-06-30 Atcor Medical Pty Ltd Methode et appareil de mesure de la pression aortique centrale
WO2006072776A1 (fr) * 2005-01-10 2006-07-13 Micro Medical Ltd Procédé permettant d’obtenir une estimation de la pression sanguine aortique d’une personne

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US6339715B1 (en) * 1999-09-30 2002-01-15 Ob Scientific Method and apparatus for processing a physiological signal
SG94349A1 (en) * 2000-10-09 2003-02-18 Healthstats Int Pte Ltd Method and device for monitoring blood pressure
US6667384B2 (en) * 2001-12-27 2003-12-23 Hercules Incorporated Methyl acrylate-diamine based polyamide resins and processes for producing the same

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Publication number Priority date Publication date Assignee Title
US6428482B1 (en) * 2000-08-11 2002-08-06 Colin Corporation Central-artery-pressure-waveform estimating apparatus
US20030236465A1 (en) * 2002-06-20 2003-12-25 Colin Corporation Blood-pressure determining apparatus
WO2005058155A1 (fr) * 2003-12-17 2005-06-30 Atcor Medical Pty Ltd Methode et appareil de mesure de la pression aortique centrale
WO2006072776A1 (fr) * 2005-01-10 2006-07-13 Micro Medical Ltd Procédé permettant d’obtenir une estimation de la pression sanguine aortique d’une personne

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508056A (ja) * 2008-11-10 2012-04-05 ヘルススタッツ インターナショナル ピーティーイー リミテッド 自立神経機能不全テストのパラメータを測定するための方法およびシステム

Also Published As

Publication number Publication date
BRPI0721728A2 (pt) 2018-10-23
TWI441618B (zh) 2014-06-21
KR101476730B1 (ko) 2014-12-29
MX2009013200A (es) 2010-02-24
EP2162063A4 (fr) 2015-07-22
AU2007354717B2 (en) 2012-08-16
TW200901935A (en) 2009-01-16
CA2689278A1 (fr) 2008-12-11
AU2007354717A1 (en) 2008-12-11
GB2454624A (en) 2009-05-20
KR20100033381A (ko) 2010-03-29
GB2454624B (en) 2012-09-12
ZA200908221B (en) 2011-02-23
JP2010528757A (ja) 2010-08-26
IL202333A (en) 2012-06-28
GB0723145D0 (en) 2008-01-02
CA2689278C (fr) 2015-11-17
IL202333A0 (en) 2010-06-30
EP2162063A1 (fr) 2010-03-17

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