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WO2008149838A1 - Nouveau produit de fractionnement de la gelée royale, son procédé de fabrication et son utilisation - Google Patents

Nouveau produit de fractionnement de la gelée royale, son procédé de fabrication et son utilisation Download PDF

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Publication number
WO2008149838A1
WO2008149838A1 PCT/JP2008/060136 JP2008060136W WO2008149838A1 WO 2008149838 A1 WO2008149838 A1 WO 2008149838A1 JP 2008060136 W JP2008060136 W JP 2008060136W WO 2008149838 A1 WO2008149838 A1 WO 2008149838A1
Authority
WO
WIPO (PCT)
Prior art keywords
fractionation product
royal jelly
product
fractionation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/060136
Other languages
English (en)
Japanese (ja)
Inventor
Masaki Miyake
Mitsukiyo Fujii
Kanso Iwaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Priority to JP2009517858A priority Critical patent/JP5479891B2/ja
Publication of WO2008149838A1 publication Critical patent/WO2008149838A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Fodder In General (AREA)
  • Jellies, Jams, And Syrups (AREA)

Abstract

L'invention concerne un produit de fractionnement de la gelée royale, qui conserve encore une activité physiologique utile de la gelée royale et présente un risque faible qu'un état allergique puisse être introduit; un procédé de fabrication du produit de fractionnement; et une utilisation du produit de fractionnement dans diverses compositions comprenant un aliment/une boisson, un aliment pour animaux, un appât de pêche, un aliment pour animaux de compagnie et une préparation externe pour la peau, telle qu'un produit cosmétique, contenant chacun le produit de fractionnement. L'invention concerne spécifiquement: un produit de fractionnement de la gelée royale, qui comprend 1 partie en masse d'acide 10-hydroxy-2-décénoïque et moins de 0,05 partie en masse d'une protéine issue de la gelée royale, qui a une activité physiologique utile de la gelée royale et qui a une propriété telle qu'aucune allergénicité vis-à-vis du produit de fractionnement n'est détectée par l'anaphylaxie cutanée passive sur un rat à l'aide d'un sérum provenant d'une souris immunisée par une quantité du produit de fractionnement telle que 45 µg d'acide 10-hydroxy-2-décénoïque sont contenus dans le produit de fractionnement; un procédé de fabrication de produit de fractionnement; et une utilisation du produit de fractionnement.
PCT/JP2008/060136 2007-06-04 2008-06-02 Nouveau produit de fractionnement de la gelée royale, son procédé de fabrication et son utilisation Ceased WO2008149838A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009517858A JP5479891B2 (ja) 2007-06-04 2008-06-02 新規ローヤルゼリー分画物とその製造方法並びに用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007148641 2007-06-04
JP2007-148641 2007-06-04

Publications (1)

Publication Number Publication Date
WO2008149838A1 true WO2008149838A1 (fr) 2008-12-11

Family

ID=40093654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060136 Ceased WO2008149838A1 (fr) 2007-06-04 2008-06-02 Nouveau produit de fractionnement de la gelée royale, son procédé de fabrication et son utilisation

Country Status (3)

Country Link
JP (1) JP5479891B2 (fr)
KR (1) KR20100023910A (fr)
WO (1) WO2008149838A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009184955A (ja) * 2008-02-06 2009-08-20 Maruzen Pharmaceut Co Ltd ＩＶ型コラーゲン産生促進剤、トランスグルタミナーゼ−１産生促進剤、セリンパルミトイルトランスフェラーゼ産生促進剤、アクアポリン３産生促進剤、インボルクリン産生促進剤、ＨＭＧ−ＣｏＡ還元酵素産生促進剤、及び、アデノシン三リン酸産生促進剤。
JP2010168290A (ja) * 2009-01-20 2010-08-05 Yamada Bee Farm Corp インターロイキン−２産生抑制剤
JP2011116718A (ja) * 2009-12-07 2011-06-16 Pola Chemical Industries Inc セラミド分泌促進剤
JP2011193819A (ja) * 2010-03-19 2011-10-06 Cosmo Plus:Kk 生ローヤルゼリー食品
WO2010139716A3 (fr) * 2009-06-05 2012-05-18 Henkel Ag & Co. Kgaa Produit cosmétique de nettoyage tensioactif contenant de la gelée royale
EP3363445A4 (fr) * 2015-10-16 2019-06-05 Tohoku University Procédé de production de fraction de gelée royale
WO2021156330A1 (fr) * 2020-02-04 2021-08-12 Dr. Kurt Wolff Gmbh & Co. Kg Composition de soin buccal pour animaux
JP2022023250A (ja) * 2020-02-19 2022-02-07 丸善製薬株式会社 Ｄｋｋ１発現促進剤および美白剤
CN114939096A (zh) * 2022-06-01 2022-08-26 杭州艾蜂健康科技有限公司 一种蜂王浆小分子水液及其制备方法和应用
CN115777926A (zh) * 2022-12-09 2023-03-14 江西汪氏蜜蜂园有限公司 一种具有增强记忆改善认知的组合物及其应用
CN117462450A (zh) * 2023-11-24 2024-01-30 山东福瑞达生物股份有限公司 一种双重修饰的10-羟基-2-癸烯酸壳聚糖微球及其制备方法和应用
CN119318615A (zh) * 2024-10-25 2025-01-17 山东福瑞达生物股份有限公司 一种含10-羟基-2-癸烯酸的组合物及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101677460B1 (ko) * 2014-05-28 2016-11-18 대한민국 알레르기성이 감소된 수용성 로열젤리를 포함하는 피부 미백 및 노화방지용 화장료 조성물
KR102324337B1 (ko) 2019-01-11 2021-11-11 김태욱 로열젤리 함유 토마토 음료 및 이의 제조방법
KR102149215B1 (ko) * 2019-12-12 2020-08-31 주식회사 바이오포스 수밀력 향상을 위한 꿀벌 사양액용 조성물 및 그의 제조방법
KR102376020B1 (ko) * 2020-05-04 2022-03-21 주식회사 두래 로얄젤리 유효성분의 추출 방법 및 이의 방법으로 추출된 유효성분을 함유하는 식물성 오일
KR102401605B1 (ko) * 2021-10-08 2022-05-25 인선열 스틱형 건초사료 및 그 제조방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003171258A (ja) * 2001-12-06 2003-06-17 Katakura Chikkarin Co Ltd 化粧品組成物
WO2004021803A1 (fr) * 2002-09-06 2004-03-18 Hayashibara, Ken Gelee royale raffinee
JP2005179235A (ja) * 2003-12-18 2005-07-07 Yamada Bee Farm ローヤルゼリー又はその処理物の水溶性画分から得られる特定の分子量画分を有効成分とする気分の障害の予防、治療又は改善用組成物
JP2005287411A (ja) * 2004-03-31 2005-10-20 Api Co Ltd 低アレルゲン化ローヤルゼリー及びその製造方法
JP2007075062A (ja) * 2005-09-16 2007-03-29 Api Co Ltd タブレット

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61176510A (ja) * 1985-01-31 1986-08-08 Pola Chem Ind Inc 美白化粧料

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003171258A (ja) * 2001-12-06 2003-06-17 Katakura Chikkarin Co Ltd 化粧品組成物
WO2004021803A1 (fr) * 2002-09-06 2004-03-18 Hayashibara, Ken Gelee royale raffinee
JP2005179235A (ja) * 2003-12-18 2005-07-07 Yamada Bee Farm ローヤルゼリー又はその処理物の水溶性画分から得られる特定の分子量画分を有効成分とする気分の障害の予防、治療又は改善用組成物
JP2005287411A (ja) * 2004-03-31 2005-10-20 Api Co Ltd 低アレルゲン化ローヤルゼリー及びその製造方法
JP2007075062A (ja) * 2005-09-16 2007-03-29 Api Co Ltd タブレット

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009184955A (ja) * 2008-02-06 2009-08-20 Maruzen Pharmaceut Co Ltd ＩＶ型コラーゲン産生促進剤、トランスグルタミナーゼ−１産生促進剤、セリンパルミトイルトランスフェラーゼ産生促進剤、アクアポリン３産生促進剤、インボルクリン産生促進剤、ＨＭＧ−ＣｏＡ還元酵素産生促進剤、及び、アデノシン三リン酸産生促進剤。
JP2010168290A (ja) * 2009-01-20 2010-08-05 Yamada Bee Farm Corp インターロイキン−２産生抑制剤
WO2010139716A3 (fr) * 2009-06-05 2012-05-18 Henkel Ag & Co. Kgaa Produit cosmétique de nettoyage tensioactif contenant de la gelée royale
JP2011116718A (ja) * 2009-12-07 2011-06-16 Pola Chemical Industries Inc セラミド分泌促進剤
JP2011193819A (ja) * 2010-03-19 2011-10-06 Cosmo Plus:Kk 生ローヤルゼリー食品
EP3363445A4 (fr) * 2015-10-16 2019-06-05 Tohoku University Procédé de production de fraction de gelée royale
WO2021156330A1 (fr) * 2020-02-04 2021-08-12 Dr. Kurt Wolff Gmbh & Co. Kg Composition de soin buccal pour animaux
JP2022023250A (ja) * 2020-02-19 2022-02-07 丸善製薬株式会社 Ｄｋｋ１発現促進剤および美白剤
CN114939096A (zh) * 2022-06-01 2022-08-26 杭州艾蜂健康科技有限公司 一种蜂王浆小分子水液及其制备方法和应用
CN115777926A (zh) * 2022-12-09 2023-03-14 江西汪氏蜜蜂园有限公司 一种具有增强记忆改善认知的组合物及其应用
CN115777926B (zh) * 2022-12-09 2024-02-27 江西汪氏蜜蜂园有限公司 一种具有增强记忆改善认知的组合物及其应用
CN117462450A (zh) * 2023-11-24 2024-01-30 山东福瑞达生物股份有限公司 一种双重修饰的10-羟基-2-癸烯酸壳聚糖微球及其制备方法和应用
CN119318615A (zh) * 2024-10-25 2025-01-17 山东福瑞达生物股份有限公司 一种含10-羟基-2-癸烯酸的组合物及其应用

Also Published As

Publication number Publication date
JP5479891B2 (ja) 2014-04-23
JPWO2008149838A1 (ja) 2010-08-26
KR20100023910A (ko) 2010-03-04

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