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WO2008149803A1 - 表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法 - Google Patents

表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法 Download PDF

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Publication number
WO2008149803A1
WO2008149803A1 PCT/JP2008/060012 JP2008060012W WO2008149803A1 WO 2008149803 A1 WO2008149803 A1 WO 2008149803A1 JP 2008060012 W JP2008060012 W JP 2008060012W WO 2008149803 A1 WO2008149803 A1 WO 2008149803A1
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WIPO (PCT)
Prior art keywords
stem cells
lymphocytic leukemia
cancer stem
acute lymphocytic
surface antigen
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Ceased
Application number
PCT/JP2008/060012
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English (en)
French (fr)
Inventor
Chikao Morimoto
Hiroto Yamazaki
Hiroko Nishida
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University of Tokyo NUC
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University of Tokyo NUC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

急性リンパ性白血球における癌幹細胞に特異的な陽性の表面抗原マーカーを見出し、これを用いて、新規の急性リンパ性白血球における癌幹細胞の分離同定するための方法及びキットを提供する。表面抗原マーカーＣＤ９０及びＣＤ１１０を指標としてＴ細胞急性リンパ性白血病（Ｔ－ＡＬＬ）における癌幹細胞を分離する。表面抗原マーカーＣＤ９か、ＣＤ９及びＣＤ９０かを指標としてＢ細胞急性リンパ性白血病（Ｂ－ＡＬＬ）における癌幹細胞を分離する。
PCT/JP2008/060012 2007-06-06 2008-05-30 表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法 Ceased WO2008149803A1 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-150912 2007-06-06
JP2007150912 2007-06-06
JP2007-159355 2007-06-15
JP2007159355 2007-06-15

Publications (1)

Publication Number Publication Date
WO2008149803A1 true WO2008149803A1 (ja) 2008-12-11

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PCT/JP2008/060012 Ceased WO2008149803A1 (ja) 2007-06-06 2008-05-30 表面抗原マーカーを用いた急性リンパ性白血病における癌幹細胞の分離同定方法

Country Status (1)

Country Link
WO (1) WO2008149803A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012031280A3 (en) * 2010-09-03 2012-07-12 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
JP2012522217A (ja) * 2009-03-24 2012-09-20 バイオセプト インコーポレイティッド 細胞の捕捉および解析のデバイスおよび方法
CN103547597A (zh) * 2011-02-18 2014-01-29 施特姆森特Rx股份有限公司 新型调节剂及使用方法
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
US9671407B2 (en) 2009-03-24 2017-06-06 Biocept, Inc. Devices and methods of cell capture and analysis
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US9777070B2 (en) 2014-04-30 2017-10-03 Pfizer Inc Anti-PTK7 antibody-drug conjugates
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
US10934351B2 (en) 2011-10-28 2021-03-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
US11124773B2 (en) 2010-10-06 2021-09-21 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell population and method for production thereof
US11536713B2 (en) 2009-12-25 2022-12-27 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
FICKERT S. ET AL.: "Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers", ARTHRITIS RES. THER., vol. 6, no. 5, 2004, pages R422 - R432, XP021011511 *
INABA T. ET AL.: "Flow cytometric analysis of Thy-1 expression in myelodysplastic syndrome", INT. J. HEMATOL., vol. 68, no. 4, 1998, pages 403 - 410 *
IRIMAJIRI K.: "Hakketsubyo to Rinsho Kensa 2 Kyusei Lymph-sei Hakketsubyo (2)", MEDICAL TECHNOLOGY, vol. 16, no. 5, 1988, pages 391 - 397 *
NISHIDA H.: "B Saibo Lymph-kei Zoketsuki Shuyo ni Okeru Gan Kansaibo no Dotei to Kaiseki", RINSHO KETSUEKI, vol. 48, no. 9, 30 September 2007 (2007-09-30), pages 874 + ABSTR. NO. OS-18-5 *
RAMZI M.M. ET AL.: "Bryostatin 1 induces ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia cells", ENZYME PROTEIN, vol. 49, 1996, pages 262 - 272, XP002916202 *
UCKUN F.M. ET AL.: "Use of a novel colony assay to evaluate the cytotoxicity of an immunotoxin containing pokeweed antiviral protein against blast progenitor cells freshly obtained from patients with common B-lineage acute lymphoblastic leukemia", J. EXP. MED., vol. 163, no. 2, 1986, pages 347 - 368, XP000611309 *
XAVIER THOMAS ET AL.: "CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia", LEUKEMIA, vol. 9, no. 2, 1995, pages 249 - 253 *
YAMAZAKI H.: "Hito Kyusei Lymph-sei Hakketsubyo ni Okeru Gan Kansaibo no Dotei", REGENERATIVE MEDICINE, vol. 7, 22 February 2008 (2008-02-22), pages 232 + ABSTR. NO. O-32-3 *
YAMAZAKI H.: "Isolation of cancer stem cells in human T-cell acute lymphoblastic leukemia cell lines", DAI 66 KAI NIHON GAN GAKKAI GAKUJUTSU SOKAI KIJI, vol. 66TH, 25 August 2007 (2007-08-25), pages 52 *
ZHANG S.-L. ET AL.: "Analysis of surface antigen on lymphoid malignancies in children", JAPANESE JOURNAL OF PEDIATRIC HEMATOLOGY, vol. 4, no. 5, 1990, pages 457 - 462 *

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9671407B2 (en) 2009-03-24 2017-06-06 Biocept, Inc. Devices and methods of cell capture and analysis
JP2012522217A (ja) * 2009-03-24 2012-09-20 バイオセプト インコーポレイティッド 細胞の捕捉および解析のデバイスおよび方法
US11719692B2 (en) 2009-03-24 2023-08-08 Biocept, Inc. Devices and methods of cell capture and analysis
US9128082B2 (en) 2009-03-24 2015-09-08 Biocept, Inc. Devices and methods of cell capture and analysis
US10527611B2 (en) 2009-03-24 2020-01-07 Biocept, Inc. Devices and methods of cell capture and analysis
US11536713B2 (en) 2009-12-25 2022-12-27 Chugai Seiyaku Kabushiki Kaisha Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein
AU2016201730B2 (en) * 2010-09-03 2018-01-25 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US9945842B2 (en) 2010-09-03 2018-04-17 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
WO2012031280A3 (en) * 2010-09-03 2012-07-12 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
US11965180B2 (en) 2010-10-06 2024-04-23 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell population and method for production thereof
US11124773B2 (en) 2010-10-06 2021-09-21 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell population and method for production thereof
US9409995B2 (en) 2011-02-18 2016-08-09 Stemcentrx, Inc. PTK7 modulators and methods of use
US10836831B2 (en) 2011-02-18 2020-11-17 Abbvie Stemcentrx Llc Anti-PTK7 antibodies and methods of use
US9914784B2 (en) 2011-02-18 2018-03-13 Abbvie Stemcentrx Llc PTK7 modulators and methods of use
CN103547597B (zh) * 2011-02-18 2017-03-15 艾伯维施特姆森特克斯有限责任公司 新型调节剂及使用方法
CN103547597A (zh) * 2011-02-18 2014-01-29 施特姆森特Rx股份有限公司 新型调节剂及使用方法
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
US10934351B2 (en) 2011-10-28 2021-03-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
US11858987B2 (en) 2011-10-28 2024-01-02 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell-specific molecule
US10087258B2 (en) 2012-02-08 2018-10-02 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
US9777070B2 (en) 2014-04-30 2017-10-03 Pfizer Inc Anti-PTK7 antibody-drug conjugates

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